Activation of the Cholinergic Antiinflammatory Pathway Ameliorates Obesity-Induced Inflammation and Insulin Resistance

• Published in: Endocrinology (Philadelphia) Vol. 152; no. 3; pp. 836 - 846
• Main Authors: Wang, XianFeng, Yang, ZhengGang, Xue, Bingzhong, Shi, Hang
• Format: Journal Article
• Language: English
• Published: Chevy Chase, MD Oxford University Press 01.03.2011; Endocrine Society
• Subjects: Acetylcholine receptors (nicotinic); Acid resistance; Adipose tissue; alpha7 Nicotinic Acetylcholine Receptor; Animal subjects; Animals; Biological and medical sciences; Blood Glucose - metabolism; Body fat; Body weight; Cell activation; Cholinergics; Cytokines; Cytokines - genetics; Cytokines - metabolism; Diabetes-Insulin-Glucagon-Gastrointestinal; Diet; Diet (weight control); Fats; Fatty acids; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - drug effects; Gene Expression Regulation - physiology; Glucose - metabolism; Glucose Clamp Technique; Homeostasis; Hormones; Infiltration; Inflammation; Inflammation - etiology; Inflammation - physiopathology; Innate immunity; Insulin; Insulin resistance; Insulin Resistance - physiology; Lipids; Macrophages; Macrophages - metabolism; Medical sciences; Metabolic diseases; Mice; Mice, Knockout; Mice, Obese; Nicotine; Nicotine - pharmacology; Obesity; Obesity - complications; Preventive health; Receptors, Nicotinic - genetics; Receptors, Nicotinic - metabolism; Recruiting; Sensitivity; Signal transduction; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-α; Vertebrates: endocrinology; Endocrinopathy; Target tissue resistance; Obesity; Nutrition disorder; Antiinflammatory agent; Metabolic diseases; Insulin resistance; Activation; Inflammation; Nutritional status; Cholinergic pathway

Obesity is associated with a chronic inflammatory state characterized by adipose tissue macrophage infiltration and inflammation, which contributes to insulin resistance. The cholinergic antiinflammatory pathway, which acts through the macrophage α7-nicotinic acetylcholine receptor (α7nAChR), is imp...