Surface-enhanced Raman spectroscopy of saliva proteins for the noninvasive differentiation of benign and malignant breast tumors

• Published in: International journal of nanomedicine Vol. 10; no. default; pp. 537 - 547
• Main Authors: Feng, Shangyuan, Huang, Shaohua, Lin, Duo, Chen, Guannan, Xu, Yuanji, Li, Yongzeng, Huang, Zufang, Pan, Jianji, Chen, Rong, Zeng, Haishan
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2015; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Biomarkers; Breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - metabolism; Case-Control Studies; Diagnosis; Discriminant Analysis; Disease; Female; Genetic aspects; Hospitals; Humans; Lung cancer; Mammography; Medical diagnosis; Medical imaging; Medical screening; Methods; Original Research; Physiological aspects; Predictive Value of Tests; Proteins; Raman spectroscopy; Saliva - chemistry; Salivary Proteins and Peptides - analysis; Salivary Proteins and Peptides - chemistry; Spectrum analysis; Spectrum Analysis, Raman - methods; Tumors; Canada; China; breast cancer; PLS-DA; saliva protein purification; SERS; noninvasive detection

The capability of saliva protein analysis, based on membrane protein purification and surface-enhanced Raman spectroscopy (SERS), for detecting benign and malignant breast tumors is presented in this paper. A total of 97 SERS spectra from purified saliva proteins were acquired from samples obtained...