Basement membrane proteins as a substrate for efficient Trypanosoma brucei differentiation in vitro

• Published in: PLoS neglected tropical diseases Vol. 15; no. 4; p. e0009284
• Main Authors: Rojas, Federico, Cayla, Mathieu, Matthews, Keith R
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.04.2021; Public Library of Science (PLoS)
• Subjects: Animals; Basement Membrane - metabolism; Biology and Life Sciences; Cell Cycle; Cell Differentiation; Composition; Culture Media; Identification and classification; Life Cycle Stages; Membrane proteins; Membrane, Basement; Natural history; Physiological aspects; Protozoan Proteins - metabolism; Quorum Sensing; Trypanosoma brucei; Trypanosoma brucei brucei - cytology; Trypanosoma brucei brucei - growth & development; Trypanosoma brucei brucei - metabolism; United Kingdom

The ability to reproduce the developmental events of trypanosomes that occur in their mammalian host in vitro offers significant potential to assist in understanding of the underlying biology of the process. For example, the transition from bloodstream slender to bloodstream stumpy forms is a quorum...