Relative Apical Sparing of Myocardial Longitudinal Strain Is Explained by Regional Differences in Total Amyloid Mass Rather Than the Proportion of Amyloid Deposits

• Published in: JACC. Cardiovascular imaging Vol. 12; no. 7; pp. 1165 - 1173
• Main Authors: Bravo, Paco E., Fujikura, Kana, Kijewski, Marie Foley, Jerosch-Herold, Michael, Jacob, Sophia, El-Sady, Mohamed Samir, Sticka, William, Dubey, Shipra, Belanger, Anthony, Park, Mi-Ae, Di Carli, Marcelo F., Kwong, Raymond Y., Falk, Rodney H., Dorbala, Sharmila
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2019
• Subjects: Aged; Amyloid - analysis; amyloidosis; Amyloidosis - diagnostic imaging; Amyloidosis - pathology; Amyloidosis - physiopathology; Aniline Compounds - administration & dosage; Cardiomyopathies - diagnosis; Cardiomyopathies - pathology; Cardiomyopathies - physiopathology; Echocardiography; Ethylene Glycols - administration & dosage; extracellular volume fraction; Female; florbetapir; Humans; longitudinal strain; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardium - chemistry; Myocardium - pathology; Positron-Emission Tomography; Predictive Value of Tests; Prospective Studies; Radiopharmaceuticals - administration & dosage; Stroke Volume; Ventricular Function, Left; wall thickening; CE; amyloidosis; extracellular volume fraction; PYP; LS; LVEF; CMR; LV; AL; LGE; SPECT; ATTR; CT; longitudinal strain; RELAPS; florbetapir; ECV; wall thickening; CA; PET; 18F; NT pro BNP

This study sought to test whether relative apical sparing (RELAPS) of left ventricular (LV) longitudinal strain (LS) in cardiac amyloidosis (CA) is explained by regional differences in markers of amyloid burden (18F-florbetapir uptake by positron emission tomography [PET] and/or extracellular volume...