The pathophysiology of anaphylaxis

• Published in: Journal of allergy and clinical immunology Vol. 140; no. 2; pp. 335 - 348
• Main Authors: Reber, Laurent L., Hernandez, Joseph D., Galli, Stephen J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2017; Elsevier Limited; Elsevier
• Subjects: Airway management; Allergies; Allergology; Anaphylaxis; Anaphylaxis - genetics; Anaphylaxis - immunology; Animal models; Animals; Antibodies; Antigens; basophils; Bees; cysteinyl leukotrienes; Disease Models, Animal; Edema; Effector cells; Enzymes; epinephrine; Food allergies; food allergy; Genetic Variation; histamine; Human subjects; Humans; Hypersensitivity; IgE; Immune response; Immunoglobulin E; Immunoglobulin G; Immunoglobulins; Immunology; Immunopathogenesis; Kinases; Life Sciences; Ligands; mast cells; Mucosa; Mutation; platelet-activating factor; Respiratory tract; Rodents; Skin; Stings; Urticaria; Venom; histamine; IgE; PAF-AH; LT; epinephrine; platelet-activating factor; basophils; mast cells; food allergy; CysLT; MPO; ASA; Anaphylaxis; BV; PAF; urticaria; cysteinyl leukotrienes; PSA

Anaphylaxis is a severe systemic hypersensitivity reaction that is rapid in onset; characterized by life-threatening airway, breathing, and/or circulatory problems; and usually associated with skin and mucosal changes. Because it can be triggered in some persons by minute amounts of antigen (eg, cer...