Non-inferiority of mammalian cell-derived quadrivalent subunit influenza virus vaccines compared to trivalent subunit influenza virus vaccines in healthy children: a phase III randomized, multicenter, double-blind clinical trial

• Published in: International journal of infectious diseases Vol. 41; no. C; pp. 65 - 72
• Main Authors: Hartvickson, Robyn, Cruz, Marilou, Ervin, John, Brandon, Donald, Forleo-Neto, Eduardo, Dagnew, Alemnew F., Chandra, Richa, Lindert, Kelly, Mateen, Ahmed Abdul
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Ltd 01.12.2015; Elsevier
• Subjects: Adolescent; Antibodies, Viral - blood; Antibody Formation; Child; Child, Preschool; Double-Blind Method; Female; Hemagglutination Inhibition Tests; Humans; Infectious Disease; Influenza; Influenza Vaccines - immunology; Influenza, Human - prevention & control; Male; MDCK; Pediatric; Pulmonary/Respiratory; Quadrivalent; Seroconversion; Trivalent; Vaccination; Vaccine; Vaccines, Inactivated - immunology; Vaccine; Quadrivalent; Trivalent; MDCK; Pediatric; Influenza

•The quadrivalent influenza vaccine (QIVc) demonstrated a similar safety profile and immune responses against all four vaccine strains without signs of immune interference on addition of an alternative lineage B strain.•QIVc met the non-inferiority criteria against all four vaccine strains.•Superior...