Non-targeted metabolomic study in plasma in rats with post-traumatic osteoarthritis model

• Published in: PloS one Vol. 20; no. 3; p. e0315708
• Main Authors: Han, Peng-fei, Li, Xi-yong, Zhang, Chang-peng, Liao, Chang-sheng, Wang, Wei-wei, Li, Yuan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.03.2025; Public Library of Science (PLoS)
• Subjects: Adenosine; Adenosine triphosphate; Age; Amino acids; AMP; Analysis; Animal models; Animals; Bioinformatics; Biology and Life Sciences; Biomarkers; Biomarkers - blood; Care and treatment; Cartilage; Chromatography; Composition; Computational biology; Computer and Information Sciences; Correlation analysis; Data analysis; Diagnosis; Dichloroacetic acid; Disease Models, Animal; Experiments; Female; Human tissues; Isocitric acid; Ketoglutaric acid; Knee; Lactose; Linolenic acid; Linolenic acids; Mass spectrometry; Medicine and Health Sciences; Menadione; Metabolism; Metabolites; Metabolome; Metabolomics; Metabolomics - methods; Osteoarthritis; Osteoarthritis - blood; Osteoarthritis - etiology; Osteoarthritis - metabolism; Phenanthridine; Proteomics; Rats; Rats, Sprague-Dawley; Reproducibility; Research and Analysis Methods; Research methodology; Risk factors; Scientific imaging; Software; Systems stability; Temperature; Trauma; China

This study aimed to examine the differential expression profiles of plasma metabolites in rat models of post-traumatic osteoarthritis (PTOA) and elucidate the roles of metabolites and their pathways in the progression of PTOA using bioinformatics analysis. Plasma samples were collected from 24 SD fe...