Fabrication of Stimuli-Responsive Quince/Mucin Co-Poly (Methacrylate) Hydrogel Matrices for the Controlled Delivery of Acyclovir Sodium: Design, Characterization and Toxicity Evaluation

• Published in: Pharmaceutics Vol. 15; no. 2; p. 650
• Main Authors: Aslam, Aysha, Ashraf, Muhammad Umer, Barkat, Kashif, Mahmood, Asif, Hussain, Muhammad Ajaz, Farid-Ul-Haq, Muhammad, Lashkar, Manar O, Gad, Heba A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2023; MDPI
• Subjects: Acyclovir; acyclovir sodium; Bioavailability; controlled release; Dosage and administration; Drug delivery systems; Drug dosages; Drugs; Electrolytes; Free radicals; Gels (Pharmacy); Health aspects; health care; Hydrogels; Materials; mucin; Nanoparticles; Patient compliance; Polymerization; Polymers; quince; Seeds; Sodium; stimuli-responsive; Viscoelasticity; Pakistan; Lahore Pakistan; Japan; Germany; acyclovir sodium; controlled release; drug discovery; mucin; stimuli-responsive; health care; quince

Free-radical polymerization technique was adopted to fabricate a stimuli-responsive intelligent quince/mucin co-poly (methacrylate) hydrogel for the controlled delivery of acyclovir sodium. The developed hydrogel matrices were appraised using different parameters, such as drug loading (%), swelling...