Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia

• Published in: Leukemia Vol. 17; no. 1; pp. 1 - 8
• Main Authors: LUO, J-M, YOSHIDA, H, NAOE, T, AKAO, Y, OHNO, R, OHNISHI, K, KOMURA, S, OHISHI, N, PAN, L, SHIGENO, K, HANAMURA, I, MIURA, K, LIDA, S, UEDA, R
• Format: Journal Article
• Language: English
• Published: London Nature Publishing 2003; Nature Publishing Group
• Subjects: Acute Disease; Animals; Antineoplastic Agents, Phytogenic - pharmacology; Apoptosis - drug effects; Biological and medical sciences; Case-Control Studies; Cercopithecus aethiops; COS Cells; Drug Resistance, Neoplasm; Etoposide - pharmacology; Genes, Dominant - genetics; Hematologic and hematopoietic diseases; Humans; In Vitro Techniques; Interleukin-3 - metabolism; Leukemia, Myeloid - genetics; Leukemia, Myeloid - metabolism; Leukemia, Myeloid - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Mutation; Phosphatidylinositol 3-Kinases - metabolism; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases - genetics; Phosphoric Monoester Hydrolases - metabolism; Phosphorylation; src Homology Domains - genetics; Transfection; Tumor Cells, Cultured; Human; myeloid leukemia; Enzyme; Pathogenesis; Acute; Phosphoric monoester hydrolases; Src Homology 2 domain; Esterases; Malignant hemopathy; Somatic mutation; Gene; Genetics; Hydrolases; SHIP; Inositol-1,4,5-trisphosphate 5-phosphatase; Acute myelocytic leukemia

The SH2 domain-containing inositol 5'-phosphatase (SHIP) is crucial in hematopoietic development. To evaluate the possible tumor suppressor role of the SHIP gene in myeloid leukemogenesis, we examined primary leukemia cells from 30 acute myeloid leukemia (AML) patients, together with eight myel...