Evidence that a naturally occurring single nucleotide polymorphism in the RagC gene of Leishmania donovani contributes to reduced virulence

• Published in: PLoS neglected tropical diseases Vol. 15; no. 2; p. e0009079
• Main Authors: Lypaczewski, Patrick, Zhang, Wen-Wei, Matlashewski, Greg
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.02.2021; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Cell Proliferation; Development and progression; Disease Models, Animal; Gene Editing; Gene mutations; Genetic aspects; Leishmania; Leishmania donovani - genetics; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Medicine and Health Sciences; Mice; Mice, Inbred BALB C; Monomeric GTP-Binding Proteins - genetics; Mutation; Parasitological research; Polymorphism, Single Nucleotide; Protozoan Proteins - genetics; Research and Analysis Methods; Single nucleotide polymorphisms; Skin; Sri Lanka; Virulence; Virulence (Microbiology); Virulence Factors - genetics; Sri Lanka

Leishmaniasis is a widespread neglected tropical disease transmitted by infected sand flies resulting in either benign cutaneous infection or fatal visceral disease. Leishmania donovani is the principal species responsible for visceral leishmaniasis, yet an atypical L . donovani has become attenuate...