TNF-α involvement in insulin resistance induced by experimental scorpion envenomation

• Published in: PLoS neglected tropical diseases Vol. 6; no. 7; p. e1740
• Main Authors: Ait-Lounis, Aouatef, Laraba-Djebari, Fatima
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2012; Public Library of Science (PLoS)
• Subjects: Adipose Tissue - physiopathology; Adipose tissues; Animals; Biology; Cytokines - analysis; Disease Models, Animal; Drug resistance; Gene expression; Gene Expression Profiling; Genetic aspects; Glucose metabolism; Health aspects; Insulin Resistance; Medicine; Mice; NF-kappaB-Inducing Kinase; Protein Serine-Threonine Kinases - metabolism; Real-Time Polymerase Chain Reaction; Scorpions; Snake Bites - complications; Tumor Necrosis Factor-alpha - metabolism; Venom; Algeria

Scorpion venom induces systemic inflammation characterized by an increase in cytokine release and chemokine production. There have been few experimental studies assessing the effects of scorpion venom on adipose tissue function in vivo. To study the adipose tissue inflammation (ATI) induced by Andro...