A Diphenylalanine Based Pentapeptide with Fibrillating Self-Assembling Properties

Peptides and their related compounds can self-assemble into diverse nanostructures of different shapes and sizes in response to various stimuli such as pH, temperature or ionic strength. Here we report the synthesis and characterization of a lysozyme derived pentapeptide and its ability to build wel...

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Published inPharmaceutics Vol. 15; no. 2; p. 371
Main Authors Jitaru, Stefania-Claudia, Neamtu, Andrei, Drochioiu, Gabi, Darie-Ion, Laura, Stoica, Iuliana, Petre, Brindusa-Alina, Gradinaru, Vasile-Robert
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 21.01.2023
MDPI
Subjects
aggregation
Amino acids
Chemical properties
Chromatography
egg white lysozyme
fluorescence
Identification and classification
Ions
MALDI-ToF
Mass spectrometry
pentapeptide
Peptides
Scientific imaging
self-assembling
Structure
Tissue engineering
Romania
United States > US
Germany
egg white lysozyme
pentapeptide
MALDI-ToF
fluorescence
AFM
self-assembling
aggregation
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Abstract Peptides and their related compounds can self-assemble into diverse nanostructures of different shapes and sizes in response to various stimuli such as pH, temperature or ionic strength. Here we report the synthesis and characterization of a lysozyme derived pentapeptide and its ability to build well-defined fibrillar structures. Lysozyme FESNF peptide fragment was synthesized by solid phase peptide synthesis using the Fmoc/t-Bu strategy, purified by analytical high-performance liquid chromatography (HPLC) and its molecular weight was confirmed by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). Spectroscopic features of this pentapeptide were investigated by UV-visible spectroscopy and fluorimetry showing the pattern of marginal phenylalanine residues within the peptide sequence. Self-assembling properties were determined using atomic force microscopy (AFM), aggregation index and thioflavin T assay (ThT). FESNF generating fibrillar structures observed by AFM and aggregation propensity were primarily influenced by pH conditions. Moreover, the experimental data were confirmed by molecular dynamics simulation studies. The obtained fibrils will be used next to explore their potential to act as support material for medical and cosmetic application.
AbstractList Peptides and their related compounds can self-assemble into diverse nanostructures of different shapes and sizes in response to various stimuli such as pH, temperature or ionic strength. Here we report the synthesis and characterization of a lysozyme derived pentapeptide and its ability to build well-defined fibrillar structures. Lysozyme FESNF peptide fragment was synthesized by solid phase peptide synthesis using the Fmoc/t-Bu strategy, purified by analytical high-performance liquid chromatography (HPLC) and its molecular weight was confirmed by matrix-assisted laser desorption/ionization mass spectrometry (MALDI–MS). Spectroscopic features of this pentapeptide were investigated by UV-visible spectroscopy and fluorimetry showing the pattern of marginal phenylalanine residues within the peptide sequence. Self-assembling properties were determined using atomic force microscopy (AFM), aggregation index and thioflavin T assay (ThT). FESNF generating fibrillar structures observed by AFM and aggregation propensity were primarily influenced by pH conditions. Moreover, the experimental data were confirmed by molecular dynamics simulation studies. The obtained fibrils will be used next to explore their potential to act as support material for medical and cosmetic application.
Audience Academic
Author Stoica, Iuliana
Neamtu, Andrei
Gradinaru, Vasile-Robert
Petre, Brindusa-Alina
Jitaru, Stefania-Claudia
Darie-Ion, Laura
Drochioiu, Gabi
AuthorAffiliation 3 Department of Physiology, “Gr. T. Popa” University of Medicine and Pharmacy, 16 University, 700115 Iasi, Romania
2 TRANSCEND—Regional Institute of Oncology, 700483 Iasi, Romania
1 Faculty of Chemistry, Alexandru Ioan Cuza University, 11 Carol I Bd., 700506 Iasi, Romania
4 “Petru Poni” Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, 700487 Iasi, Romania
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36839694$$D View this record in MEDLINE/PubMed
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Keywords egg white lysozyme
pentapeptide
MALDI-ToF
fluorescence
AFM
self-assembling
aggregation
Language English
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Snippet Peptides and their related compounds can self-assemble into diverse nanostructures of different shapes and sizes in response to various stimuli such as pH,...
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SubjectTerms aggregation
Amino acids
Chemical properties
Chromatography
egg white lysozyme
fluorescence
Identification and classification
Ions
MALDI-ToF
Mass spectrometry
pentapeptide
Peptides
Scientific imaging
self-assembling
Structure
Tissue engineering
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Title A Diphenylalanine Based Pentapeptide with Fibrillating Self-Assembling Properties
URI https://www.ncbi.nlm.nih.gov/pubmed/36839694
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