Causal associations of brain structure with bone mineral density: a large-scale genetic correlation study

• Published in: Bone Research Vol. 11; no. 1; pp. 37 - 585
• Main Authors: Guo, Bin, Wang, Chao, Zhu, Yong, Liu, Zhi, Long, Haitao, Ruan, Zhe, Lin, Zhangyuan, Fan, Zhihua, Li, Yusheng, Zhao, Shushan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.07.2023; Springer Nature B.V; Department of Orthopedics,Xiangya Hospital,Central South University,Changsha 410008 Hunan,China%Department of Dermatology,Xiangya Hospital,Central South University,Changsha,China%Department of Orthopedics,Xiangya Hospital,Central South University,Changsha 410008 Hunan,China; National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China; Nature Publishing Group
• Subjects: 631/443/376; 631/443/811; Bone density; Internal Medicine; Medicine; Medicine & Public Health; Orthopedics; Osteoporosis

In this study, we aimed to investigate the causal associations of brain structure with bone mineral density (BMD). Based on the genome-wide association study (GWAS) summary statistics of 1 325 brain imaging-derived phenotypes (BIDPs) of brain structure from the UK Biobank and GWAS summary datasets o...