Long-Term Plasticity of Visually Evoked Potentials in Humans is Altered in Major Depression

• Published in: Biological psychiatry (1969) Vol. 62; no. 5; pp. 373 - 380
• Main Authors: Normann, Claus, Schmitz, Daniela, Fürmaier, Andrea, Döing, Carsten, Bach, Michael
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2007; Elsevier Science
• Subjects: Adult and adolescent clinical studies; Analysis of Variance; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Biological and medical sciences; Depression; Depression - drug therapy; Depression - pathology; Depression - physiopathology; Electroencephalography - methods; Evoked Potentials, Visual - drug effects; Evoked Potentials, Visual - physiology; Humans; long-term synaptic plasticity; LTP; Medical sciences; Mood disorders; Neural Inhibition - drug effects; Neural Inhibition - physiology; Neural Inhibition - radiation effects; Neuronal Plasticity - drug effects; Neuronal Plasticity - physiology; Photic Stimulation - methods; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Reaction Time - drug effects; Reaction Time - physiology; Reaction Time - radiation effects; selective serotonin reuptake inhibitors; Sertraline - pharmacology; Sertraline - therapeutic use; Time Factors; Visual Cortex - drug effects; Visual Cortex - physiopathology; Visual Cortex - radiation effects; visually evoked potentials; long-term synaptic plasticity; Depression; LTP; humans; selective serotonin reuptake inhibitors; visually evoked potentials; Mood disorder; Human; Electrophysiology; Long term; Selective serotonin reuptake inhibitor; Electrodiagnosis; Evoked potential; Vision; Synaptic plasticity; Perception

Long-term synaptic plasticity is a ubiquitous form of neuronal plasticity that regulates the strength of synaptic transmission in many brain areas. However, most data on long-term potentiation and long-term depression rely on research in animal brain slices. The role of synaptic plasticity in physio...