Missing Data in Clinical Research: A Tutorial on Multiple Imputation

• Published in: Canadian journal of cardiology Vol. 37; no. 9; pp. 1322 - 1331
• Main Authors: Austin, Peter C., White, Ian R., Lee, Douglas S., van Buuren, Stef
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.09.2021; Pulsus Group
• Subjects: Clinical Trials as Topic; Data Interpretation, Statistical; Humans; Research Design; Review

Missing data is a common occurrence in clinical research. Missing data occurs when the value of the variables of interest are not measured or recorded for all subjects in the sample. Common approaches to addressing the presence of missing data include complete-case analyses, where subjects with miss...