Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation

• Published in: Molecular and cellular endocrinology Vol. 332; no. 1-2; pp. 180 - 188
• Main Authors: Varlakhanova, Natalia, Hahm, Johnnie B., Privalsky, Martin L.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 30.01.2011
• Subjects: Animals; Architecture; cell proliferation; Corepressor complex; Dimer; Dimerization; Erk; genes; Humans; MAP kinases; mitogen-activated protein kinase; Mitogen-Activated Protein Kinase 1 - genetics; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinases - metabolism; Multiprotein Complexes - chemistry; Multiprotein Complexes - metabolism; Nuclear Receptor Co-Repressor 2 - chemistry; Nuclear Receptor Co-Repressor 2 - genetics; Nuclear Receptor Co-Repressor 2 - metabolism; Phosphorylation; Protein Structure, Quaternary; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - metabolism; Signal Transduction; SMRT; thyroid hormone receptors; transcription (genetics); transcription factors; Corepressor complex; SMRT; Dimer; MAP kinases; Erk

The SMRT (Silencing Mediator of Retinoid and Thyroid hormone receptors) corepressor mediates gene repression by nuclear receptors and other transcriptional factors. The SMRT protein serves as a key nucleating core that organizes the assembly of a larger corepressor complex. We report here that SMRT...