Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity

Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its possible roles in obesity development and in adipocyte metabolism are unclear. The objective of the present study is to review the current data on Se status in obesity and to discuss the interference between S...

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Published inBiomolecules (Basel, Switzerland) Vol. 10; no. 4; p. 658
Main Authors Tinkov, Alexey A., Ajsuvakova, Olga P., Filippini, Tommaso, Zhou, Ji-Chang, Lei, Xin Gen, Gatiatulina, Eugenia R., Michalke, Bernhard, Skalnaya, Margarita G., Vinceti, Marco, Aschner, Michael, Skalny, Anatoly V.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 24.04.2020
MDPI
Subjects
adipocyte
Adipocytes
Adipogenesis
Adipose tissue
Adipose Tissue - metabolism
Adipose Tissue - physiology
Analysis
Animals
Bioavailability
Biomarkers
Biosynthesis
Body fat
Body mass index
Cancer
Carbohydrate metabolism
Cytoplasm
Diabetes
Disease
Endoplasmic reticulum
Glutathione
Glutathione peroxidase
Homeostasis
Humans
Influence
Insulin
Insulin resistance
Lipid metabolism
Lipolysis
Metabolism
Metabolites
Microbiota
Neurodegeneration
Obesity
Obesity - blood
Obesity - metabolism
Pathogenesis
Physiological aspects
Physiology
Proteins
Review
Reviews
Selenium
Selenium (Nutrient)
Selenium - metabolism
selenoprotein
Selenoproteins
Selenoproteins - blood
Selenoproteins - metabolism
Signal Transduction
Supplements
Thioredoxin
Thyroid gland
Womens health
Russia
selenoprotein
adipogenesis
selenium
obesity
adipocyte
Online AccessGet full text
ISSN2218-273X
2218-273X
DOI10.3390/biom10040658

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Abstract Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its possible roles in obesity development and in adipocyte metabolism are unclear. The objective of the present study is to review the current data on Se status in obesity and to discuss the interference between Se and selenoprotein metabolism in adipocyte physiology and obesity pathogenesis. The overview and meta-analysis of the studies on blood Se and selenoprotein P (SELENOP) levels, as well as glutathione peroxidase (GPX) activity in obese subjects, have yielded heterogenous and even conflicting results. Laboratory studies demonstrate that Se may modulate preadipocyte proliferation and adipogenic differentiation, and also interfere with insulin signaling, and regulate lipolysis. Knockout models have demonstrated that the selenoprotein machinery, including endoplasmic reticulum-resident selenoproteins together with GPXs and thioredoxin reductases (TXNRDs), are tightly related to adipocyte development and functioning. In conclusion, Se and selenoproteins appear to play an essential role in adipose tissue physiology, although human data are inconsistent. Taken together, these findings do not support the utility of Se supplementation to prevent or alleviate obesity in humans. Further human and laboratory studies are required to elucidate associations between Se metabolism and obesity.
AbstractList Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its possible roles in obesity development and in adipocyte metabolism are unclear. The objective of the present study is to review the current data on Se status in obesity and to discuss the interference between Se and selenoprotein metabolism in adipocyte physiology and obesity pathogenesis. The overview and meta-analysis of the studies on blood Se and selenoprotein P (SELENOP) levels, as well as glutathione peroxidase (GPX) activity in obese subjects, have yielded heterogenous and even conflicting results. Laboratory studies demonstrate that Se may modulate preadipocyte proliferation and adipogenic differentiation, and also interfere with insulin signaling, and regulate lipolysis. Knockout models have demonstrated that the selenoprotein machinery, including endoplasmic reticulum-resident selenoproteins together with GPXs and thioredoxin reductases (TXNRDs), are tightly related to adipocyte development and functioning. In conclusion, Se and selenoproteins appear to play an essential role in adipose tissue physiology, although human data are inconsistent. Taken together, these findings do not support the utility of Se supplementation to prevent or alleviate obesity in humans. Further human and laboratory studies are required to elucidate associations between Se metabolism and obesity.
Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its possible roles in obesity development and in adipocyte metabolism are unclear. The objective of the present study is to review the current data on Se status in obesity and to discuss the interference between Se and selenoprotein metabolism in adipocyte physiology and obesity pathogenesis. The overview and meta-analysis of the studies on blood Se and selenoprotein P (SELENOP) levels, as well as glutathione peroxidase (GPX) activity in obese subjects, have yielded heterogenous and even conflicting results. Laboratory studies demonstrate that Se may modulate preadipocyte proliferation and adipogenic differentiation, and also interfere with insulin signaling, and regulate lipolysis. Knockout models have demonstrated that the selenoprotein machinery, including endoplasmic reticulum-resident selenoproteins together with GPXs and thioredoxin reductases (TXNRDs), are tightly related to adipocyte development and functioning. In conclusion, Se and selenoproteins appear to play an essential role in adipose tissue physiology, although human data are inconsistent. Taken together, these findings do not support the utility of Se supplementation to prevent or alleviate obesity in humans. Further human and laboratory studies are required to elucidate associations between Se metabolism and obesity.Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its possible roles in obesity development and in adipocyte metabolism are unclear. The objective of the present study is to review the current data on Se status in obesity and to discuss the interference between Se and selenoprotein metabolism in adipocyte physiology and obesity pathogenesis. The overview and meta-analysis of the studies on blood Se and selenoprotein P (SELENOP) levels, as well as glutathione peroxidase (GPX) activity in obese subjects, have yielded heterogenous and even conflicting results. Laboratory studies demonstrate that Se may modulate preadipocyte proliferation and adipogenic differentiation, and also interfere with insulin signaling, and regulate lipolysis. Knockout models have demonstrated that the selenoprotein machinery, including endoplasmic reticulum-resident selenoproteins together with GPXs and thioredoxin reductases (TXNRDs), are tightly related to adipocyte development and functioning. In conclusion, Se and selenoproteins appear to play an essential role in adipose tissue physiology, although human data are inconsistent. Taken together, these findings do not support the utility of Se supplementation to prevent or alleviate obesity in humans. Further human and laboratory studies are required to elucidate associations between Se metabolism and obesity.
Audience Academic
Author Vinceti, Marco
Zhou, Ji-Chang
Tinkov, Alexey A.
Lei, Xin Gen
Gatiatulina, Eugenia R.
Aschner, Michael
Skalnaya, Margarita G.
Ajsuvakova, Olga P.
Filippini, Tommaso
Michalke, Bernhard
Skalny, Anatoly V.
AuthorAffiliation 3 Federal Research Centre of Biological Systems and Agro-Technologies of the Russian Academy of Sciences, 460000 Orenburg, Russia
8 Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
4 CREAGEN, Environmental, Genetic and Nutritional Epidemiology Research Center, University of Modena and Reggio Emilia, 41121 Modena, Italy
2 IM Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia
1 Yaroslavl State University, 150003 Yaroslavl, Russia; oajsuvakova@gmail.com (O.P.A.)
9 Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
5 School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518100, China
7 All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), 117216 Moscow, Russia
6 Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
AuthorAffiliation_xml – name: 8 Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
– name: 2 IM Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia
– name: 3 Federal Research Centre of Biological Systems and Agro-Technologies of the Russian Academy of Sciences, 460000 Orenburg, Russia
– name: 4 CREAGEN, Environmental, Genetic and Nutritional Epidemiology Research Center, University of Modena and Reggio Emilia, 41121 Modena, Italy
– name: 6 Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
– name: 9 Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
– name: 1 Yaroslavl State University, 150003 Yaroslavl, Russia; oajsuvakova@gmail.com (O.P.A.)
– name: 5 School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518100, China
– name: 7 All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), 117216 Moscow, Russia
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  givenname: Alexey A.
  surname: Tinkov
  fullname: Tinkov, Alexey A.
– sequence: 2
  givenname: Olga P.
  surname: Ajsuvakova
  fullname: Ajsuvakova, Olga P.
– sequence: 3
  givenname: Tommaso
  orcidid: 0000-0003-2100-0344
  surname: Filippini
  fullname: Filippini, Tommaso
– sequence: 4
  givenname: Ji-Chang
  surname: Zhou
  fullname: Zhou, Ji-Chang
– sequence: 5
  givenname: Xin Gen
  surname: Lei
  fullname: Lei, Xin Gen
– sequence: 6
  givenname: Eugenia R.
  surname: Gatiatulina
  fullname: Gatiatulina, Eugenia R.
– sequence: 7
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  orcidid: 0000-0001-6376-2588
  surname: Michalke
  fullname: Michalke, Bernhard
– sequence: 8
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  surname: Skalnaya
  fullname: Skalnaya, Margarita G.
– sequence: 9
  givenname: Marco
  orcidid: 0000-0002-0551-2473
  surname: Vinceti
  fullname: Vinceti, Marco
– sequence: 10
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  surname: Aschner
  fullname: Aschner, Michael
– sequence: 11
  givenname: Anatoly V.
  surname: Skalny
  fullname: Skalny, Anatoly V.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32344656$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1002/jgm.2945
10.1351/PAC-CON-11-09-01
10.3390/nu7042209
10.1186/1475-2891-12-18
10.1007/s11906-017-0701-x
10.1089/ars.2013.5428
10.3390/nu11020477
10.1210/en.2016-1680
10.1016/j.toxlet.2013.11.016
10.33549/physiolres.931866
10.1152/physrev.00034.2017
10.1371/journal.pone.0020832
10.1007/s11695-011-0458-2
10.1016/j.orcp.2016.07.004
10.1210/en.2004-1361
10.1007/s00125-013-2839-7
10.1074/jbc.M107250200
10.1007/978-3-319-41283-2
10.1016/j.toxlet.2013.10.005
10.1006/abbi.2000.1829
10.1096/fj.01-0398fje
10.1089/ars.2009.2895
10.1007/s11010-014-2236-7
10.1152/ajpendo.90921.2008
10.1016/j.taap.2019.114744
10.1016/j.bbagen.2018.05.023
10.1074/jbc.M506949200
10.1385/BTER:89:2:165
10.1093/cdn/nzz044.OR11-02-19
10.1093/ajcn/87.6.1939
10.1016/j.redox.2018.11.004
10.1515/hsz-2014-0102
10.1002/mnfr.201800784
10.1016/j.metabol.2011.01.014
10.1016/j.ajog.2011.07.034
10.1074/jbc.M111.267666
10.3390/ijms12106936
10.3390/nu8010024
10.1089/ars.2010.3526
10.3945/jn.112.159020
10.1530/EJE-14-0067
10.1016/j.numecd.2010.09.005
10.2508/chikusan.87.345
10.1007/978-3-319-95390-8
10.1089/scd.2010.0364
10.1055/s-2006-949527
10.1007/s11325-011-0536-7
10.1371/journal.pone.0016794
10.1016/j.celrep.2017.01.064
10.1007/s12011-012-9519-1
10.1038/oby.2008.536
10.1016/j.mehy.2016.02.008
10.1007/s12011-019-01781-9
10.1023/A:1006819906820
10.1096/fasebj.29.1_supplement.136.5
10.1002/dmrr.3074
10.1152/ajpendo.00196.2002
10.1073/pnas.0308096101
10.1096/fasebj.24.1_supplement.547.8
10.1016/j.jtemb.2014.07.016
10.1016/j.jmb.2010.05.026
10.1016/j.gene.2004.06.028
10.5483/BMBRep.2017.50.11.174
10.1210/jc.2011-0101
10.1152/ajpendo.00380.2010
10.1016/j.jtemb.2012.09.006
10.1038/s41598-018-35067-2
10.3390/molecules23112882
10.1186/1750-1326-6-30
10.1093/jn/nxz287
10.1159/000502357
10.1016/j.cmet.2010.09.015
10.3389/fendo.2018.00254
10.1139/apnm-2017-0639
10.1016/j.jnutbio.2014.03.018
10.1080/10715760100300291
10.1007/s11695-015-1808-2
10.1016/j.metabol.2014.01.009
10.1016/j.neuroscience.2017.05.050
10.1515/REVEH.2009.24.3.231
10.5352/JLS.2009.19.4.423
10.1111/j.1474-9726.2011.00670.x
10.3945/jn.116.229955
10.1159/000368833
10.1007/s12011-017-1044-9
10.1007/978-3-642-22236-8
10.1159/000494295
10.1016/j.cmet.2009.08.009
10.1210/me.2008-0023
10.1016/j.bbagen.2009.03.026
10.1172/JCI21625
10.1089/thy.2018.0015
10.1002/pmic.201100355
10.1089/ars.2019.7905
10.1007/s12011-016-0785-1
10.3945/jn.115.211318
10.1002/biof.5520200205
10.1016/j.jnutbio.2015.11.003
10.1007/s12011-012-9464-z
10.1210/jc.2009-2534
10.4161/adip.29853
10.1002/jcb.10395
10.1016/j.numecd.2010.02.007
10.1002/oby.21841
10.1007/s12011-017-1122-z
10.1016/j.ejphar.2017.09.032
10.3109/17477160903055945
10.4103/1735-1995.168403
10.1152/ajpcell.00064.2019
10.5409/wjcp.v3.i1.6
10.1038/srep28080
10.1016/j.nut.2010.09.003
10.1038/nrendo.2011.174
10.1016/j.obmed.2019.100118
10.1016/j.freeradbiomed.2013.07.036
10.1111/obr.12584
10.1016/j.arcmed.2012.09.001
10.1016/j.metabol.2014.12.010
10.3390/nu10060727
10.1194/jlr.M034603
10.1186/s12967-015-0395-2
10.1038/s41467-017-01863-z
10.1093/jn/133.5.1517S
10.1093/jn/134.4.762
10.1136/bmjdrc-2016-000253
10.1371/journal.pone.0037312
10.1248/bpb.16.6
10.1007/s12011-018-1521-9
10.1038/sj.ijo.0802066
10.1007/978-3-319-52031-5
10.1042/BSR20171252
10.1007/s12011-014-0024-6
10.1016/j.bbrc.2018.08.057
10.1128/MCB.00293-12
10.1089/ars.2015.6277
10.5352/JLS.2014.24.10.1085
10.1016/j.freeradbiomed.2013.09.025
10.1074/jbc.M113.471235
10.1007/978-94-007-7500-8
10.1016/j.abb.2015.06.024
10.1007/s00394-018-1624-2
10.3892/mmr.2013.1859
10.1515/hsz-2015-0305
10.1007/s00726-009-0246-7
10.5483/BMBRep.2015.48.4.272
10.1093/abbs/gms008
10.1016/j.freeradbiomed.2012.01.017
10.1016/j.jnutbio.2013.02.012
10.1016/j.exger.2007.11.002
10.1111/j.1748-1716.2012.02409.x
10.1111/j.1440-1681.2011.05493.x
10.1016/j.bbrc.2012.08.125
10.7554/eLife.09800
10.1677/JOE-07-0277
10.1155/2018/2464652
10.1007/s00441-006-0194-4
10.14310/horm.2002.11190
10.2174/1389557517666161104125022
10.1007/s12011-016-0777-1
10.1016/S0022-2275(20)31994-5
10.1016/j.metabol.2010.05.011
10.1016/j.freeradbiomed.2013.07.016
10.1016/j.jsbmb.2013.10.020
10.1002/9783527694907
10.1073/pnas.1508943112
10.2337/db10-0758
10.1017/S0007114511005289
10.1016/j.freeradbiomed.2018.09.026
10.7717/peerj.7352
10.1194/jlr.P081620
10.1007/s12011-015-0552-8
10.1007/s00018-018-2745-8
10.1089/ars.2012.5081
10.1016/j.jff.2015.05.008
10.1016/j.orcp.2012.07.004
10.1016/j.yexcr.2004.08.030
10.1038/oby.2008.419
10.1007/978-981-13-2529-8
10.1089/ars.2010.3295
10.1021/pr100268f
10.1186/s13287-019-1240-y
10.1089/ars.2009.2973
10.1007/s12011-010-8940-6
10.1016/S0963-9969(01)00188-0
10.1038/s41418-018-0180-x
10.2478/s11658-010-0042-0
10.1016/S0021-9258(19)40166-X
10.1677/joe.0.1550255
10.1016/j.soard.2013.10.003
10.1007/s11010-016-2679-0
10.1038/sj.ejcn.1602230
10.1024/0300-9831/a000101
10.1126/sciadv.aav0198
10.1016/j.jtemb.2020.126470
10.3892/ijo.2013.2182
10.1016/j.jinorgbio.2012.04.011
10.1007/s00125-008-1055-3
10.3389/fphys.2014.00479
10.1002/biof.1176
10.3109/07435800.2014.952016
10.1038/ijo.2014.45
10.1016/j.freeradbiomed.2018.02.038
10.1016/j.nut.2019.02.009
10.1371/journal.pone.0095518
10.4103/0976-7800.92529
10.1016/j.molmet.2018.10.005
10.1089/thy.2010.0068
10.1016/j.abb.2013.02.021
10.3109/10715762.2011.591793
10.3945/jn.112.164764
10.1093/cdn/nzz044.P24-023-19
10.1016/j.physbeh.2015.07.029
10.1016/j.jtemb.2019.07.005
10.1016/j.jtemb.2016.12.009
10.1007/s10654-018-0422-8
10.4093/dmj.2013.37.1.63
10.3390/molecules14031263
10.1161/HYPERTENSIONAHA.115.06040
10.1016/j.semarthrit.2019.07.014
10.1074/jbc.M111.235945
10.14310/horm.2002.11182
10.1016/j.nut.2008.09.015
10.1016/j.cmet.2012.12.007
10.1096/fj.11-181990
10.1007/s12011-019-01771-x
10.1007/978-0-387-89382-2
10.1677/joe.1.06872
10.1016/j.jtemb.2014.11.006
10.1016/S0140-6736(00)02490-9
10.3390/nu10091203
10.3390/antiox8090357
10.1016/j.molmet.2015.04.001
10.1016/j.jtemb.2014.09.005
10.1038/ijo.2011.101
10.1111/febs.14608
10.1016/j.ceca.2017.05.001
10.1089/ars.2013.5361
10.1007/s12011-016-0691-6
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Keywords selenoprotein
adipogenesis
selenium
obesity
adipocyte
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References Vinceti (ref_19) 2014; 230
Zhao (ref_30) 2015; 145
Liu (ref_58) 2020; 59
ref_259
Steinbrenner (ref_34) 2016; 595
Pepper (ref_184) 2011; 14
Misu (ref_146) 2010; 12
ref_133
ref_135
Chen (ref_218) 2019; 3
Ozgen (ref_83) 2012; 25
Ha (ref_157) 2019; 192
Kim (ref_38) 2013; 19
Gan (ref_257) 2002; 89
Jilkova (ref_202) 2010; 59
ref_246
Kuzuya (ref_90) 2008; 87
Ding (ref_216) 2012; 44
Steinbrenner (ref_9) 2013; 536
Men (ref_155) 2018; 503
Zhang (ref_145) 2010; 300
Rayman (ref_10) 2000; 356
Hida (ref_144) 2000; 41
Combs (ref_48) 2015; 7
Santini (ref_197) 2014; 171
Fatani (ref_57) 2016; 174
Calvo (ref_199) 2011; 60
Uthus (ref_222) 2011; 45
Takamura (ref_227) 2008; 16
Akarsu (ref_205) 2016; 124
Langhardt (ref_167) 2018; 11
Yoon (ref_106) 2002; 16
Nido (ref_114) 2016; 171
(ref_1) 2018; 127
Liu (ref_23) 2012; 142
Burk (ref_94) 2009; 1790
Karaouzene (ref_68) 2011; 21
Das (ref_195) 2014; 96
Calzadilla (ref_163) 2011; 12
Klatka (ref_52) 2015; 29
Jobgen (ref_174) 2009; 37
Donma (ref_120) 2016; 89
Hassan (ref_105) 2014; 25
Olza (ref_92) 2014; 7
Pitts (ref_220) 2013; 288
Shin (ref_224) 2019; 317
Rayman (ref_16) 2019; 19
Seale (ref_236) 2012; 32
Wu (ref_253) 2017; 158
Seale (ref_234) 2015; 23
Kim (ref_156) 2011; 23
Zhao (ref_24) 2016; 146
Albuali (ref_82) 2014; 3
Park (ref_104) 2014; 44
Kim (ref_110) 2012; 426
Wiacek (ref_111) 2010; 24
Horibata (ref_46) 2018; 59
Ferro (ref_74) 2011; 143
Olusi (ref_69) 2002; 26
Hammarstedt (ref_103) 2018; 98
Coppola (ref_212) 2005; 146
Ojeda (ref_255) 2019; 382
Yiannikouris (ref_134) 2015; 66
Prigol (ref_130) 2012; 150
Ko (ref_97) 2014; 38
ref_260
Olsson (ref_159) 2011; 60
Lu (ref_59) 2016; 4
Sirajudeen (ref_60) 2017; 43
Jensen (ref_136) 2004; 301
Castro (ref_153) 2016; 397
Adani (ref_31) 2020; 54
Bougoulia (ref_84) 2006; 5
Mita (ref_25) 2017; 8
ref_213
Sfar (ref_81) 2013; 12
Feng (ref_88) 2013; 56
Loh (ref_238) 2017; 18
Ullrey (ref_128) 1987; 65
Urs (ref_138) 2004; 134
Koch (ref_95) 2017; 25
Obregon (ref_200) 2014; 5
Niu (ref_89) 2012; 108
Sargeant (ref_102) 2017; 43
Boelen (ref_211) 2006; 190
McClung (ref_178) 2004; 101
Furukawa (ref_171) 2017; 114
Katunga (ref_183) 2015; 4
Merry (ref_180) 2014; 20
Gharipour (ref_96) 2017; 19
Zhang (ref_150) 2009; 23
Ortega (ref_51) 2012; 82
Kobayashi (ref_170) 2009; 296
Chen (ref_101) 2017; 11
ref_206
Letsiou (ref_56) 2014; 40
Chattopadhyay (ref_168) 2015; 399
Asayama (ref_172) 2001; 34
Wang (ref_186) 2014; 20
Peinado (ref_142) 2012; 12
Zhou (ref_115) 2014; 9
Vinceti (ref_20) 2018; 33
Mistry (ref_8) 2012; 206
Steinbrenner (ref_141) 2019; 20
Wang (ref_232) 2019; 5
Ali (ref_143) 2018; 38
Xie (ref_160) 2010; 9
Alasfar (ref_50) 2011; 21
Wang (ref_179) 2008; 51
ref_119
Galinier (ref_173) 2006; 281
Koch (ref_99) 2019; 58
Guerrero (ref_91) 2015; 32
ref_230
Kim (ref_182) 2019; 57
Castillo (ref_207) 2011; 60
ref_233
Mitchell (ref_241) 1997; 155
Chen (ref_79) 2015; 40
Fujisawa (ref_231) 2018; 28
Lefebvre (ref_54) 2014; 10
Cioffi (ref_209) 2018; 9
Zeng (ref_118) 2009; 14
Duarte (ref_67) 2019; 63
ref_228
ref_109
Yokoyama (ref_214) 2016; 87
Bougoulia (ref_85) 2006; 5
Tobe (ref_40) 2018; 1862
Lu (ref_37) 2014; 66
Kasaikina (ref_4) 2012; 1823
Tajaddini (ref_28) 2015; 20
Iannantuoni (ref_87) 2019; 19
Tang (ref_29) 2019; 7
Lee (ref_175) 2008; 22
Tinahones (ref_77) 2009; 17
Kim (ref_116) 2012; 150
Hosseini (ref_27) 2017; 175
Franck (ref_176) 2011; 96
ref_14
Song (ref_193) 2010; 20
Xia (ref_252) 2015; 64
ref_12
ref_11
(ref_76) 2012; 43
Abboud (ref_137) 2014; 144
Saito (ref_26) 2019; 66
Liu (ref_226) 2018; 183
Bradley (ref_203) 2018; 2018
ref_18
ref_17
Ustundag (ref_78) 2007; 25
Donovan (ref_229) 2010; 400
Jankovic (ref_165) 2014; 63
Amirkhizi (ref_70) 2014; 8
Kim (ref_113) 2015; 17
Hermsdorff (ref_66) 2009; 25
Yin (ref_151) 2014; 7
Luo (ref_177) 2008; 43
Spina (ref_73) 2013; 65
Novoselov (ref_223) 2010; 12
Parks (ref_237) 2013; 17
Kasaikina (ref_15) 2011; 25
Hu (ref_139) 2013; 375
Yang (ref_169) 2000; 378
Galan (ref_55) 2005; 59
Shon (ref_108) 2013; 11
Taylor (ref_71) 2008; 7
Hei (ref_124) 1998; 178
Imhoff (ref_191) 2011; 16
Wang (ref_117) 2016; 415
Kim (ref_154) 2013; 54
Sneddon (ref_7) 2011; 84
Lee (ref_72) 2012; 16
Hung (ref_161) 2004; 340
Shetty (ref_132) 2018; 181
Kurylowicz (ref_204) 2015; 13
Cabanelas (ref_210) 2006; 38
Steinbrenner (ref_21) 2013; 65
Zhang (ref_44) 2019; 188
Kim (ref_217) 2011; 10
Tinkov (ref_129) 2017; 175
(ref_80) 2010; 5
Ying (ref_47) 2019; 192
Chang (ref_189) 2019; 63
Suh (ref_112) 2017; 50
Gong (ref_244) 2018; 127
Tinkov (ref_187) 2018; 75
Sriram (ref_166) 2019; 10
Labunskyy (ref_258) 2011; 14
Pinto (ref_126) 2012; 114
Lundholm (ref_164) 2008; 196
Papamargaritis (ref_53) 2015; 31
Schomburg (ref_39) 2012; 8
Goyal (ref_86) 2011; 2
Panchal (ref_261) 2017; 19
Fonseca (ref_208) 2015; 112
Lipinski (ref_3) 2019; 19
Park (ref_107) 2009; 19
Wang (ref_127) 2014; 224
Wijaya (ref_64) 2013; 27
Choi (ref_100) 2013; 37
Lim (ref_98) 2016; 26
Niersmann (ref_149) 2019; 35
Christian (ref_240) 2015; 4
Ortega (ref_201) 2012; 36
Yamasaki (ref_162) 2006; 326
Rajalin (ref_188) 2014; 395
Pitts (ref_33) 2018; 70
Ezaki (ref_121) 1990; 265
Lee (ref_158) 2019; 26
Yoon (ref_254) 2010; 28
Burger (ref_239) 2002; 283
ref_65
Seale (ref_235) 2019; 3
ref_63
Li (ref_251) 2015; 29
Yagishita (ref_247) 2017; 18
Chen (ref_219) 2019; 150
Heart (ref_123) 2003; 88
Govindarajah (ref_225) 2016; 29
Vinceti (ref_262) 2009; 24
Henry (ref_245) 2015; 4
Almanza (ref_43) 2019; 286
Gunawardena (ref_75) 2019; 15
Ueki (ref_125) 1993; 16
Cominetti (ref_93) 2011; 27
Papp (ref_2) 2010; 12
Kuroiwa (ref_147) 2015; 2
Nomura (ref_198) 2011; 21
Bortolatto (ref_249) 2015; 151
Liang (ref_131) 2014; 160
Reddy (ref_140) 2011; 6
Schriever (ref_248) 2017; 357
Chanoine (ref_256) 2004; 20
ref_36
ref_35
ref_32
Ovadia (ref_192) 2011; 286
Bortolatto (ref_250) 2017; 815
Oo (ref_61) 2018; 8
(ref_242) 2002; 35
Wronska (ref_263) 2012; 205
Camargo (ref_196) 2013; 24
Ling (ref_221) 2011; 38
Zeng (ref_22) 2012; 52
Park (ref_148) 2014; 24
Stapleton (ref_122) 1997; 1355
Yan (ref_185) 2012; 142
Chutkow (ref_194) 2011; 286
Alehagen (ref_13) 2015; 31
Sohn (ref_243) 2015; 48
Burk (ref_41) 2003; 133
Solovyev (ref_215) 2019; 56
ref_45
ref_42
Loh (ref_181) 2009; 10
Peng (ref_190) 2016; 6
Liang (ref_152) 2001; 276
Arnaud (ref_62) 2012; 22
ref_49
ref_5
ref_6
References_xml – volume: 19
  start-page: e2945
  year: 2017
  ident: ref_96
  article-title: Association of expression of selenoprotein P in mRNA and protein levels with metabolic syndrome in subjects with cardiovascular disease: Results of the Selenegene study
  publication-title: J. Gene Med.
  doi: 10.1002/jgm.2945
– volume: 84
  start-page: 239
  year: 2011
  ident: ref_7
  article-title: Selenium and vascular health
  publication-title: Pure Appl. Chem.
  doi: 10.1351/PAC-CON-11-09-01
– volume: 7
  start-page: 2209
  year: 2015
  ident: ref_48
  article-title: Biomarkers of selenium status
  publication-title: Nutrients
  doi: 10.3390/nu7042209
– volume: 12
  start-page: 18
  year: 2013
  ident: ref_81
  article-title: Antioxidant enzymes activities in obese Tunisian children
  publication-title: Nutr. J.
  doi: 10.1186/1475-2891-12-18
– volume: 19
  start-page: 10
  year: 2017
  ident: ref_261
  article-title: Selenium, vanadium, and chromium as micronutrients to improve metabolic syndrome
  publication-title: Curr. Hypertens. Rep.
  doi: 10.1007/s11906-017-0701-x
– volume: 20
  start-page: 2114
  year: 2014
  ident: ref_180
  article-title: High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2013.5428
– ident: ref_63
  doi: 10.3390/nu11020477
– volume: 158
  start-page: 419
  year: 2017
  ident: ref_253
  article-title: Type 3 deiodinase role on central thyroid hormone action affects the leptin-melanocortin system and circadian activity
  publication-title: Endocrinology
  doi: 10.1210/en.2016-1680
– volume: 230
  start-page: 295
  year: 2014
  ident: ref_19
  article-title: Selenium neurotoxicity in humans: Bridging laboratory and epidemiologic studies
  publication-title: Toxicol. Lett.
  doi: 10.1016/j.toxlet.2013.11.016
– volume: 66
  start-page: 19
  year: 2019
  ident: ref_26
  article-title: Selenoprotein P as an in vivo redox regulator: Disorders related to its deficiency and excess
  publication-title: J. Clin. Biochem. Nutr.
– volume: 59
  start-page: 561
  year: 2010
  ident: ref_202
  article-title: Modulation of type I iodothyronine 5’-deiodinase activity in white adipose tissue by nutrition: Possible involvement of leptin
  publication-title: Physiol. Res.
  doi: 10.33549/physiolres.931866
– volume: 98
  start-page: 1911
  year: 2018
  ident: ref_103
  article-title: Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00034.2017
– ident: ref_206
  doi: 10.1371/journal.pone.0020832
– volume: 21
  start-page: 1710
  year: 2011
  ident: ref_50
  article-title: Selenium is significantly depleted among morbidly obese female patients seeking bariatric surgery
  publication-title: Obes. Surg.
  doi: 10.1007/s11695-011-0458-2
– volume: 11
  start-page: 227
  year: 2017
  ident: ref_101
  article-title: Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance
  publication-title: Obes. Res. Clin. Pract.
  doi: 10.1016/j.orcp.2016.07.004
– volume: 146
  start-page: 2827
  year: 2005
  ident: ref_212
  article-title: Inverse shift in circulating corticosterone and leptin levels elevates hypothalamic deiodinase type 2 in fasted rats
  publication-title: Endocrinology
  doi: 10.1210/en.2004-1361
– volume: 56
  start-page: 985
  year: 2013
  ident: ref_88
  article-title: Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: A randomised controlled trial
  publication-title: Diabetologia
  doi: 10.1007/s00125-013-2839-7
– volume: 276
  start-page: 49066
  year: 2001
  ident: ref_152
  article-title: Transcriptional profiling reveals global defects in energy metabolism, lipoprotein, and bile acid synthesis and transport with reversal by leptin treatment in ob/ob mouse liver
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M107250200
– ident: ref_230
  doi: 10.1007/978-3-319-41283-2
– volume: 224
  start-page: 16
  year: 2014
  ident: ref_127
  article-title: High selenium impairs hepatic insulin sensitivity through opposite regulation of ROS
  publication-title: Toxicol. Lett.
  doi: 10.1016/j.toxlet.2013.10.005
– volume: 378
  start-page: 259
  year: 2000
  ident: ref_169
  article-title: Mitochondrial adaptations to obesity-related oxidant stress
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1006/abbi.2000.1829
– volume: 16
  start-page: 111
  year: 2002
  ident: ref_106
  article-title: Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways
  publication-title: FASEB J.
  doi: 10.1096/fj.01-0398fje
– volume: 12
  start-page: 829
  year: 2010
  ident: ref_223
  article-title: Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2009.2895
– volume: 399
  start-page: 95
  year: 2015
  ident: ref_168
  article-title: Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects
  publication-title: Mol. Cell. Biochem.
  doi: 10.1007/s11010-014-2236-7
– volume: 296
  start-page: E1326
  year: 2009
  ident: ref_170
  article-title: Dysregulated glutathione metabolism links to impaired insulin action in adipocytes
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.90921.2008
– volume: 382
  start-page: 114744
  year: 2019
  ident: ref_255
  article-title: High-and low-selenium diets affect endocrine energy balance during early programming
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/j.taap.2019.114744
– volume: 1862
  start-page: 2433
  year: 2018
  ident: ref_40
  article-title: Delivery of selenium to selenophosphate synthetase for selenoprotein biosynthesis
  publication-title: Biochim. Biophys. Acta Gen. Subj.
  doi: 10.1016/j.bbagen.2018.05.023
– volume: 281
  start-page: 12682
  year: 2006
  ident: ref_173
  article-title: Adipose tissue proadipogenic redox changes in obesity
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M506949200
– volume: 89
  start-page: 165
  year: 2002
  ident: ref_257
  article-title: Effects of selenium overexposure on glutathione peroxidase and thioredoxin reductase gene expressions and activities
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1385/BTER:89:2:165
– volume: 3
  start-page: nzz044.OR11-02-19
  year: 2019
  ident: ref_218
  article-title: Loss of Selenoprotein V Predisposes Mice to Body Fat Accumulation (OR11-02-19)
  publication-title: Curr. Dev. Nutr.
  doi: 10.1093/cdn/nzz044.OR11-02-19
– volume: 87
  start-page: 1939
  year: 2008
  ident: ref_90
  article-title: Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/87.6.1939
– volume: 20
  start-page: 489
  year: 2019
  ident: ref_141
  article-title: Selenium-binding protein 1 (SELENBP1) is a marker of mature adipocytes
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2018.11.004
– volume: 395
  start-page: 667
  year: 2014
  ident: ref_188
  article-title: Upregulation of the thioredoxin-dependent redox system during differentiation of 3T3-L1 cells to adipocytes
  publication-title: Biol. Chem.
  doi: 10.1515/hsz-2014-0102
– volume: 63
  start-page: 1800784
  year: 2019
  ident: ref_189
  article-title: N-γ-(l-Glutamyl)-l-Selenomethionine Inhibits Fat Storage via the Stearoyl-CoA Desaturases FAT-6 and FAT-7 and the Selenoprotein TRXR-1 in Caenorhabditis elegans
  publication-title: Mol. Nutr. Food Res.
  doi: 10.1002/mnfr.201800784
– volume: 60
  start-page: 1207
  year: 2011
  ident: ref_199
  article-title: Presence and regulation of D1 and D2 deiodinases in rat white adipose tissue
  publication-title: Metabolism
  doi: 10.1016/j.metabol.2011.01.014
– volume: 206
  start-page: 21
  year: 2012
  ident: ref_8
  article-title: Selenium in reproductive health
  publication-title: Am. J. Obstet. Gynecol.
  doi: 10.1016/j.ajog.2011.07.034
– volume: 23
  start-page: 2882
  year: 2011
  ident: ref_156
  article-title: Selenium inhibits adipogenesis through suppression of ER-stress and induction of selenoprotein S
  publication-title: FASEB J.
– volume: 286
  start-page: 29139
  year: 2011
  ident: ref_194
  article-title: Thioredoxin regulates adipogenesis through thioredoxin-interacting protein (Txnip) protein stability
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.267666
– volume: 12
  start-page: 6936
  year: 2011
  ident: ref_163
  article-title: N-acetylcysteine reduces markers of differentiation in 3T3-L1 adipocytes
  publication-title: Int. J. Mol.
  doi: 10.3390/ijms12106936
– ident: ref_65
  doi: 10.3390/nu8010024
– volume: 14
  start-page: 2327
  year: 2011
  ident: ref_258
  article-title: Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2010.3526
– volume: 142
  start-page: 1410
  year: 2012
  ident: ref_23
  article-title: Prolonged dietary Se deficiency or excess does not globally affect selenoprotein gene expression and(or) protein production in various tissues of pigs
  publication-title: J. Nutr.
  doi: 10.3945/jn.112.159020
– volume: 171
  start-page: R137
  year: 2014
  ident: ref_197
  article-title: The crosstalk between thyroid gland and adipose tissue: Signal integration in health and disease
  publication-title: Eur. J. Endocrinol.
  doi: 10.1530/EJE-14-0067
– volume: 28
  start-page: 132
  year: 2010
  ident: ref_254
  article-title: The Effect of Selenium-rich Hot Spring Water on Serum Leptin and IGF-1 in a Rat Model
  publication-title: Korean J. Androl.
– volume: 22
  start-page: 517
  year: 2012
  ident: ref_62
  article-title: Gender differences in copper, zinc and selenium status in diabetic-free metabolic syndrome European population–The IMMIDIET study
  publication-title: Nutr. Metab. Cardiovasc. Dis.
  doi: 10.1016/j.numecd.2010.09.005
– volume: 87
  start-page: 345
  year: 2016
  ident: ref_214
  article-title: Anti-obese effect of iodine-enriched yolk in cultured adipocytes
  publication-title: Nihon Chikusan Gakkaiho
  doi: 10.2508/chikusan.87.345
– ident: ref_17
  doi: 10.1007/978-3-319-95390-8
– volume: 20
  start-page: 1529
  year: 2010
  ident: ref_193
  article-title: Role of thioredoxin 1 and thioredoxin 2 on proliferation of human adipose tissue-derived mesenchymal stem cells
  publication-title: Stem Cells Dev.
  doi: 10.1089/scd.2010.0364
– volume: 38
  start-page: 481
  year: 2006
  ident: ref_210
  article-title: Leptin acute modulation of the 5′-deiodinase activities in hypothalamus, pituitary and brown adipose tissue of fed rats
  publication-title: Horm. Metab. Res.
  doi: 10.1055/s-2006-949527
– volume: 16
  start-page: 511
  year: 2012
  ident: ref_72
  article-title: The association of oxidative stress with central obesity in obstructive sleep apnea
  publication-title: Sleep Breath.
  doi: 10.1007/s11325-011-0536-7
– ident: ref_135
  doi: 10.1371/journal.pone.0016794
– volume: 18
  start-page: 2030
  year: 2017
  ident: ref_247
  article-title: Nrf2 improves leptin and insulin resistance provoked by hypothalamic oxidative stress
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.01.064
– volume: 150
  start-page: 360
  year: 2012
  ident: ref_116
  article-title: Selenium significantly inhibits adipocyte hypertrophy and abdominal fat accumulation in OLETF rats via induction of fatty acid β-oxidation
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-012-9519-1
– volume: 17
  start-page: 240
  year: 2009
  ident: ref_77
  article-title: Oxidative stress in severely obese persons is greater in those with insulin resistance
  publication-title: Obesity
  doi: 10.1038/oby.2008.536
– volume: 89
  start-page: 79
  year: 2016
  ident: ref_120
  article-title: Promising link between selenium and peroxisome proliferator activated receptor gamma in the treatment protocols of obesity as well as depression
  publication-title: Med. Hypotheses
  doi: 10.1016/j.mehy.2016.02.008
– volume: 192
  start-page: 38
  year: 2019
  ident: ref_47
  article-title: Systems biology of selenium and complex disease
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-019-01781-9
– volume: 178
  start-page: 367
  year: 1998
  ident: ref_124
  article-title: Stimulation of MAP kinase and S6 kinase by vanadium and selenium in rat adipocytes
  publication-title: Mol. Cell. Biochem.
  doi: 10.1023/A:1006819906820
– volume: 29
  start-page: 136.5
  year: 2015
  ident: ref_251
  article-title: Changes in Growth and Feed Efficiency in Chickens Supplemented with Supernutritional and Excess Selenium are Associated with Changes in Appetite
  publication-title: FASEB J.
  doi: 10.1096/fasebj.29.1_supplement.136.5
– volume: 35
  start-page: e3074
  year: 2019
  ident: ref_149
  article-title: Omentin-regulated proteins combine a pro-inflammatory phenotype with an anti-inflammatory counterregulation in human adipocytes: A proteomics analysis
  publication-title: Diabetes Metab. Res.
  doi: 10.1002/dmrr.3074
– volume: 283
  start-page: E980
  year: 2002
  ident: ref_239
  article-title: Central stimulatory effect of leptin on T3production is mediated by brown adipose tissue type II deiodinase
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00196.2002
– volume: 101
  start-page: 8852
  year: 2004
  ident: ref_178
  article-title: Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0308096101
– volume: 24
  start-page: 547
  year: 2010
  ident: ref_111
  article-title: Sodium selenate inhibits adipogenesis in vitro
  publication-title: FASEB J.
  doi: 10.1096/fasebj.24.1_supplement.547.8
– volume: 124
  start-page: 11
  year: 2016
  ident: ref_205
  article-title: Subcutaneous adipose tissue type II deiodinase gene expression reduced in obese individuals with metabolic syndrome
  publication-title: Exp. Clin. Endocrinol.
– volume: 7
  start-page: 41
  year: 2014
  ident: ref_151
  article-title: Hypoxia induced changes of SePP1 expression in rat preadipocytes and its impact on vascular fibroblasts
  publication-title: Int. J. Clin. Exp. Med.
– volume: 29
  start-page: 116
  year: 2015
  ident: ref_52
  article-title: Serum and urinary selenium levels in obese children: A cross-sectional study
  publication-title: J. Trace Elem. Med. Biol.
  doi: 10.1016/j.jtemb.2014.07.016
– volume: 400
  start-page: 659
  year: 2010
  ident: ref_229
  article-title: The efficiency of selenocysteine incorporation is regulated by translation initiation factors
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2010.05.026
– volume: 340
  start-page: 141
  year: 2004
  ident: ref_161
  article-title: Gene expression profiles of early adipogenesis in human mesenchymal stem cells
  publication-title: Gene
  doi: 10.1016/j.gene.2004.06.028
– volume: 50
  start-page: 572
  year: 2017
  ident: ref_112
  article-title: Antioxidant effects of selenocysteine on replicative senescence in human adipose-derived mesenchymal stem cells
  publication-title: BMB Rep.
  doi: 10.5483/BMBRep.2017.50.11.174
– volume: 96
  start-page: E1308
  year: 2014
  ident: ref_195
  article-title: An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2011-0101
– volume: 300
  start-page: E77
  year: 2010
  ident: ref_145
  article-title: Reducing selenoprotein P expression suppresses adipocyte differentiation as a result of increased preadipocyte inflammation
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00380.2010
– volume: 27
  start-page: 112
  year: 2013
  ident: ref_64
  article-title: Association between selenium nutritional status and metabolic risk factors in men with visceral obesity
  publication-title: J. Trace Elem. Med. Biol.
  doi: 10.1016/j.jtemb.2012.09.006
– volume: 8
  start-page: 16727
  year: 2018
  ident: ref_61
  article-title: Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-35067-2
– ident: ref_109
  doi: 10.3390/molecules23112882
– volume: 6
  start-page: 30
  year: 2011
  ident: ref_140
  article-title: Similarities and differences in structure, expression, and functions of VLDLR and ApoER2
  publication-title: Mol. Neurodegener.
  doi: 10.1186/1750-1326-6-30
– volume: 150
  start-page: 483
  year: 2019
  ident: ref_219
  article-title: Knockout of Selenoprotein V Affects Regulation of Selenoprotein Expression by Dietary Selenium and Fat Intakes in Mice
  publication-title: J. Nutr.
  doi: 10.1093/jn/nxz287
– volume: 54
  start-page: 1
  year: 2020
  ident: ref_31
  article-title: Selenium and Other Trace Elements in the Etiology of Parkinson’s Disease: A Systematic Review and Meta-Analysis of Case-Control Studies
  publication-title: Neuroepidemiology
  doi: 10.1159/000502357
– volume: 12
  start-page: 483
  year: 2010
  ident: ref_146
  article-title: A liver-derived secretory protein, selenoprotein P, causes insulin resistance
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2010.09.015
– volume: 9
  start-page: 254
  year: 2018
  ident: ref_209
  article-title: Effect of iodothyronines on thermogenesis: Focus on brown adipose tissue
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2018.00254
– volume: 43
  start-page: 482
  year: 2017
  ident: ref_102
  article-title: The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men
  publication-title: Appl. Physiol. Nutr. Metab.
  doi: 10.1139/apnm-2017-0639
– volume: 25
  start-page: 858
  year: 2014
  ident: ref_105
  article-title: Selenium promotes adipogenic determination and differentiation of chicken embryonic fibroblasts with regulation of genes involved in fatty acid uptake, triacylglycerol synthesis and lipolysis
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2014.03.018
– volume: 34
  start-page: 337
  year: 2001
  ident: ref_172
  article-title: Effect of obesity and troglitazone on expression of two glutathione peroxidases: Cellular and extracellular types in serum, kidney and adipose tissue
  publication-title: Free Radic. Res.
  doi: 10.1080/10715760100300291
– volume: 26
  start-page: 825
  year: 2016
  ident: ref_98
  article-title: Longitudinal changes in serum levels of angiopoietin-like protein 6 and selenoprotein P after gastric bypass surgery
  publication-title: Obes. Surg.
  doi: 10.1007/s11695-015-1808-2
– volume: 63
  start-page: 661
  year: 2014
  ident: ref_165
  article-title: Differences in the redox status of human visceral and subcutaneous adipose tissues–relationships to obesity and metabolic risk
  publication-title: Metabolism
  doi: 10.1016/j.metabol.2014.01.009
– volume: 357
  start-page: 241
  year: 2017
  ident: ref_248
  article-title: Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2017.05.050
– volume: 24
  start-page: 231
  year: 2009
  ident: ref_262
  article-title: Risk of chronic low-dose selenium overexposure in humans: Insights from epidemiology and biochemistry
  publication-title: Rev. Environ. Health
  doi: 10.1515/REVEH.2009.24.3.231
– volume: 19
  start-page: 423
  year: 2009
  ident: ref_107
  article-title: AMP-activated kinase regulates adipocyte differentiation process in 3T3-L1 adipocytes treated with selenium
  publication-title: J. Life Sci.
  doi: 10.5352/JLS.2009.19.4.423
– volume: 10
  start-page: 277
  year: 2011
  ident: ref_217
  article-title: Nuclear Argonaute 2 regulates adipose tissue-derived stem cell survival through direct control of miR10b and selenoprotein N1 expression
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9726.2011.00670.x
– volume: 146
  start-page: 1625
  year: 2016
  ident: ref_24
  article-title: High dietary selenium intake alters lipid metabolism and protein synthesis in liver and muscle of pigs
  publication-title: J. Nutr.
  doi: 10.3945/jn.116.229955
– volume: 7
  start-page: 130
  year: 2014
  ident: ref_92
  article-title: Association of genetic polymorphisms for glutathione peroxidase genes with obesity in Spanish children
  publication-title: Lifestyle Genom.
  doi: 10.1159/000368833
– volume: 181
  start-page: 54
  year: 2018
  ident: ref_132
  article-title: Uptake and utilization of selenium from selenoprotein P
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-017-1044-9
– ident: ref_42
  doi: 10.1007/978-3-642-22236-8
– volume: 11
  start-page: 475
  year: 2018
  ident: ref_167
  article-title: Effects of Weight Loss on Glutathione Peroxidase 3 Serum Concentrations and Adipose Tissue Expression in Human Obesity
  publication-title: Obes. Facts
  doi: 10.1159/000494295
– volume: 10
  start-page: 260
  year: 2009
  ident: ref_181
  article-title: Reactive oxygen species enhance insulin sensitivity
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2009.08.009
– volume: 22
  start-page: 2176
  year: 2008
  ident: ref_175
  article-title: Dysregulation of adipose glutathione peroxidase 3 in obesity contributes to local and systemic oxidative stress
  publication-title: Mol. Endocrinol.
  doi: 10.1210/me.2008-0023
– volume: 1790
  start-page: 1441
  year: 2009
  ident: ref_94
  article-title: Selenoprotein P—Expression, functions, and roles in mammals
  publication-title: BBA Gen. Subj.
  doi: 10.1016/j.bbagen.2009.03.026
– volume: 114
  start-page: 1752
  year: 2017
  ident: ref_171
  article-title: Increased oxidative stress in obesity and its impact on metabolic syndrome
  publication-title: J. Clin. Invest
  doi: 10.1172/JCI21625
– volume: 28
  start-page: 1221
  year: 2018
  ident: ref_231
  article-title: A novel homozygous selenocysteine insertion sequence binding protein 2 (SECISBP2, SBP2) gene mutation in a turkish boy
  publication-title: Thyroid
  doi: 10.1089/thy.2018.0015
– volume: 12
  start-page: 607
  year: 2012
  ident: ref_142
  article-title: Proteomic characterization of adipose tissue constituents, a necessary step for understanding adipose tissue complexity
  publication-title: Proteomics
  doi: 10.1002/pmic.201100355
– ident: ref_36
  doi: 10.1089/ars.2019.7905
– volume: 175
  start-page: 287
  year: 2017
  ident: ref_27
  article-title: Association between antioxidant intake/status and obesity: A systematic review of observational studies
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-016-0785-1
– volume: 145
  start-page: 1394
  year: 2015
  ident: ref_30
  article-title: Expression of selenoprotein genes is affected by obesity of pigs fed a high-fat diet
  publication-title: Nutr. J.
  doi: 10.3945/jn.115.211318
– volume: 20
  start-page: 109
  year: 2004
  ident: ref_256
  article-title: Selenium deficiency impairs corticosterone and leptin responses to adrenocorticotropin in the rat
  publication-title: Biofactors
  doi: 10.1002/biof.5520200205
– volume: 29
  start-page: 73
  year: 2016
  ident: ref_225
  article-title: In utero exposure of rats to high-fat diets perturbs gene expression profiles and cancer susceptibility of prepubertal mammary glands
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2015.11.003
– volume: 150
  start-page: 272
  year: 2012
  ident: ref_130
  article-title: Comparative excretion and tissue distribution of selenium in mice and rats following treatment with diphenyl diselenide
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-012-9464-z
– volume: 96
  start-page: E413
  year: 2011
  ident: ref_176
  article-title: Identification of adipocyte genes regulated by caloric intake
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2009-2534
– volume: 4
  start-page: 50
  year: 2015
  ident: ref_240
  article-title: Transcriptional fingerprinting of “browning” white fat identifies NRG4 as a novel adipokine
  publication-title: Adipocyte
  doi: 10.4161/adip.29853
– volume: 88
  start-page: 719
  year: 2003
  ident: ref_123
  article-title: Insulin-like and non-insulin-like selenium actions in 3T3-L1 adipocytes
  publication-title: J. Cell. Biochem.
  doi: 10.1002/jcb.10395
– volume: 21
  start-page: 792
  year: 2011
  ident: ref_68
  article-title: Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: A comparison of older with young men
  publication-title: Nutr. Metab. Cardiovasc. Dis.
  doi: 10.1016/j.numecd.2010.02.007
– volume: 25
  start-page: 1128
  year: 2017
  ident: ref_95
  article-title: Circulating selenoprotein P levels in relation to MRI-derived body fat volumes, liver fat content, and metabolic disorders
  publication-title: Obesity
  doi: 10.1002/oby.21841
– volume: 183
  start-page: 102
  year: 2018
  ident: ref_226
  article-title: Effect of low-selenium/high-fat diet on pig peripheral blood lymphocytes: Perspectives from selenoproteins, heat shock proteins, and cytokines
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-017-1122-z
– volume: 815
  start-page: 241
  year: 2017
  ident: ref_250
  article-title: Hypothalamic pathways regulate the anorectic action of p-chloro-diphenyl diselenide in rats
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2017.09.032
– volume: 57
  start-page: 1
  year: 2019
  ident: ref_182
  article-title: Deficiency of glutathione peroxidase-1 and catalase attenuated diet-induced obesity and associated metabolic disorders
  publication-title: Acta Diabetol.
– volume: 5
  start-page: 56
  year: 2010
  ident: ref_80
  article-title: Is obesity associated with oxidative stress in children?
  publication-title: Int. J. Pediatr. Obes.
  doi: 10.3109/17477160903055945
– volume: 65
  start-page: 1712
  year: 1987
  ident: ref_128
  article-title: Biochemical and physiological indicators of selenium status in animals
  publication-title: J. Lipid Res.
– ident: ref_18
  doi: 10.1007/978-3-319-95390-8
– volume: 20
  start-page: 782
  year: 2015
  ident: ref_28
  article-title: A systematic review on the association of serum selenium and metabolic syndrome
  publication-title: J. Res. Med. Sci.
  doi: 10.4103/1735-1995.168403
– volume: 317
  start-page: 1172
  year: 2019
  ident: ref_224
  article-title: Selenoprotein W Deficiency Does Not Affect Oxidative Stress and Insulin Sensitivity in the Skeletal Muscle of High-fat Diet-fed Obese Mice
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00064.2019
– volume: 3
  start-page: 6
  year: 2014
  ident: ref_82
  article-title: Evaluation of oxidant-antioxidant status in overweight and morbidly obese Saudi children
  publication-title: World J. Clin. Pediatr.
  doi: 10.5409/wjcp.v3.i1.6
– volume: 6
  start-page: 28080
  year: 2016
  ident: ref_190
  article-title: Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness
  publication-title: Sci. Rep.
  doi: 10.1038/srep28080
– ident: ref_35
  doi: 10.1007/978-3-319-41283-2
– volume: 27
  start-page: 891
  year: 2011
  ident: ref_93
  article-title: Associations between glutathione peroxidase-1 Pro198Leu polymorphism, selenium status, and DNA damage levels in obese women after consumption of Brazil nuts
  publication-title: Nutrition
  doi: 10.1016/j.nut.2010.09.003
– ident: ref_6
  doi: 10.1007/978-3-319-41283-2
– volume: 8
  start-page: 160
  year: 2012
  ident: ref_39
  article-title: Selenium, selenoproteins and the thyroid gland: Interactions in health and disease
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2011.174
– volume: 15
  start-page: 100118
  year: 2019
  ident: ref_75
  article-title: Increased lipid peroxidation and erythrocyte glutathione peroxidase activity of patients with type 2 diabetes mellitus: Implications for obesity and central obesity
  publication-title: Obes. Med.
  doi: 10.1016/j.obmed.2019.100118
– volume: 66
  start-page: 75
  year: 2014
  ident: ref_37
  article-title: The thioredoxin antioxidant system
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2013.07.036
– volume: 18
  start-page: 1227
  year: 2017
  ident: ref_238
  article-title: Human brown adipose tissue as a target for obesity management; beyond cold-induced thermogenesis
  publication-title: Obes. Rev.
  doi: 10.1111/obr.12584
– volume: 43
  start-page: 541
  year: 2012
  ident: ref_76
  article-title: Serum levels of glutathione peroxidase 3 in overweight and obese subjects from central Mexico
  publication-title: Arch. Med. Res.
  doi: 10.1016/j.arcmed.2012.09.001
– volume: 64
  start-page: 566
  year: 2015
  ident: ref_252
  article-title: Role of thyroid hormone homeostasis in obesity-prone and obesity-resistant mice fed a high-fat diet
  publication-title: Metabolism
  doi: 10.1016/j.metabol.2014.12.010
– ident: ref_49
  doi: 10.3390/nu10060727
– volume: 54
  start-page: 2069
  year: 2013
  ident: ref_154
  article-title: Dexamethasone-induced selenoprotein S degradation is required for adipogenesis
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M034603
– volume: 13
  start-page: 31
  year: 2015
  ident: ref_204
  article-title: Obesity is associated with a decrease in expression but not with the hypermethylation of thermogenesis-related genes in adipose tissues
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-015-0395-2
– volume: 8
  start-page: 1
  year: 2017
  ident: ref_25
  article-title: Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01863-z
– volume: 133
  start-page: 1517S
  year: 2003
  ident: ref_41
  article-title: Selenoprotein metabolism and function: Evidence for more than one function for selenoprotein P
  publication-title: J. Nutr.
  doi: 10.1093/jn/133.5.1517S
– volume: 134
  start-page: 762
  year: 2004
  ident: ref_138
  article-title: Gene expression profiling in human preadipocytes and adipocytes by microarray analysis
  publication-title: J. Nutr.
  doi: 10.1093/jn/134.4.762
– volume: 4
  start-page: e000253
  year: 2016
  ident: ref_59
  article-title: High serum selenium levels are associated with increased risk for diabetes mellitus independent of central obesity and insulin resistance
  publication-title: BMJ Open Diabetes Res. Care
  doi: 10.1136/bmjdrc-2016-000253
– ident: ref_228
  doi: 10.1371/journal.pone.0037312
– volume: 16
  start-page: 6
  year: 1993
  ident: ref_125
  article-title: Increase in lipoprotein lipase activity in isolated rat adipose tissue by selenate
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.16.6
– volume: 188
  start-page: 189
  year: 2019
  ident: ref_44
  article-title: The thioredoxin-like family of selenoproteins: Implications in aging and age-related degeneration
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-018-1521-9
– volume: 26
  start-page: 1159
  year: 2002
  ident: ref_69
  article-title: Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans
  publication-title: Int. J. Obes.
  doi: 10.1038/sj.ijo.0802066
– ident: ref_119
  doi: 10.1007/978-3-319-52031-5
– volume: 38
  start-page: BSR20171252
  year: 2018
  ident: ref_143
  article-title: Multiple intracellular signaling pathways orchestrate adipocytic differentiation of human bone marrow stromal stem cells
  publication-title: Biosci. Rep.
  doi: 10.1042/BSR20171252
– volume: 160
  start-page: 41
  year: 2014
  ident: ref_131
  article-title: Effect of selenium on selenoprotein expression in the adipose tissue of chickens
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-014-0024-6
– volume: 503
  start-page: 2866
  year: 2018
  ident: ref_155
  article-title: Selenoprotein S protects against adipocyte death through mediation of the IRE1α-sXBP1 pathway
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2018.08.057
– volume: 32
  start-page: 4141
  year: 2012
  ident: ref_236
  article-title: Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00293-12
– volume: 23
  start-page: 761
  year: 2015
  ident: ref_234
  article-title: Diet-induced obesity in the selenocysteine lyase knockout mouse
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2015.6277
– volume: 24
  start-page: 1085
  year: 2014
  ident: ref_148
  article-title: Effects of Selenate on Adipocyte Differentiation and the Expression of Selenoproteins in 3T3-L1 Cells
  publication-title: J. Life Sci.
  doi: 10.5352/JLS.2014.24.10.1085
– volume: 65
  start-page: 1315
  year: 2013
  ident: ref_73
  article-title: Anthropometric indices and selenium status in British adults: The UK National Diet and Nutrition Survey
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2013.09.025
– volume: 288
  start-page: 26121
  year: 2013
  ident: ref_220
  article-title: Deletion of selenoprotein M leads to obesity without cognitive deficits
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M113.471235
– ident: ref_133
  doi: 10.1007/978-94-007-7500-8
– volume: 595
  start-page: 113
  year: 2016
  ident: ref_34
  article-title: Selenoproteins: Antioxidant selenoenzymes and beyond
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1016/j.abb.2015.06.024
– volume: 58
  start-page: 1067
  year: 2019
  ident: ref_99
  article-title: Dietary pattern associated with selenoprotein P and MRI-derived body fat volumes, liver signal intensity, and metabolic disorders
  publication-title: Eur. J. Nutr.
  doi: 10.1007/s00394-018-1624-2
– volume: 9
  start-page: 683
  year: 2014
  ident: ref_115
  article-title: Selenium-enriched exopolysaccharides produced by Enterobacter cloacae Z0206 alleviate adipose inflammation in diabetic KKAy mice through the AMPK/SirT1 pathway
  publication-title: Mol. Med. Rep.
  doi: 10.3892/mmr.2013.1859
– volume: 397
  start-page: 709
  year: 2016
  ident: ref_153
  article-title: The two faces of reactive oxygen species (ROS) in adipocyte function and dysfunction
  publication-title: Biol. Chem.
  doi: 10.1515/hsz-2015-0305
– volume: 37
  start-page: 187
  year: 2009
  ident: ref_174
  article-title: High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue
  publication-title: Amino Acids
  doi: 10.1007/s00726-009-0246-7
– volume: 48
  start-page: 229
  year: 2015
  ident: ref_243
  article-title: Network of hypothalamic neurons that control appetite
  publication-title: BMB Rep.
  doi: 10.5483/BMBRep.2015.48.4.272
– volume: 2
  start-page: 150
  year: 2015
  ident: ref_147
  article-title: Up-regulation of growth-inhibitory or tumor suppressive genes by overexpression of C/EBPα or C/EBPβ in ras-transformed NIH3T3 cells
  publication-title: Integr. Mol. Med.
– volume: 44
  start-page: 394
  year: 2012
  ident: ref_216
  article-title: Proteomic profiling of lipid droplet-associated proteins in primary adipocytes of normal and obese mouse
  publication-title: Acta Biochim. Biophys. Sin.
  doi: 10.1093/abbs/gms008
– volume: 52
  start-page: 1335
  year: 2012
  ident: ref_22
  article-title: A high-selenium diet induced insulin resistance in gestating rats and their offspring
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2012.01.017
– volume: 32
  start-page: 1516
  year: 2015
  ident: ref_91
  article-title: Glutathione peroxidase-1 Pro200Leu polymorphism (rs1050450) is associated with morbid obesity independently of the presence of prediabetes or diabetes in women from Central Mexico
  publication-title: Nutr. Hosp.
– volume: 24
  start-page: 1717
  year: 2013
  ident: ref_196
  article-title: Antioxidant system response is modified by dietary fat in adipose tissue of metabolic syndrome patients
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2013.02.012
– volume: 43
  start-page: 154
  year: 2008
  ident: ref_177
  article-title: Adipose tissue-specific PPARγ deficiency increases resistance to oxidative stress
  publication-title: Exp. Gerontol.
  doi: 10.1016/j.exger.2007.11.002
– volume: 205
  start-page: 194
  year: 2012
  ident: ref_263
  article-title: Structural and biochemical characteristics of various white adipose tissue depots
  publication-title: Acta Physiol.
  doi: 10.1111/j.1748-1716.2012.02409.x
– volume: 38
  start-page: 239
  year: 2011
  ident: ref_221
  article-title: MicroRNA-375 promotes 3T3-L1 adipocyte differentiation through modulation of extracellular signal-regulated kinase signalling
  publication-title: Clin. Exp. Pharmacol. Physiol.
  doi: 10.1111/j.1440-1681.2011.05493.x
– volume: 426
  start-page: 551
  year: 2012
  ident: ref_110
  article-title: Selenate inhibits adipogenesis through induction of transforming growth factor-β1 (TGF-β1) signaling
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2012.08.125
– volume: 4
  start-page: e09800
  year: 2015
  ident: ref_245
  article-title: Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss
  publication-title: Elife
  doi: 10.7554/eLife.09800
– volume: 196
  start-page: 547
  year: 2008
  ident: ref_164
  article-title: Effects of estrogen on gene expression profiles in mouse hypothalamus and white adipose tissue: Target genes include glutathione peroxidase 3 and cell death-inducing DNA fragmentation factor, alpha-subunit-like effector A
  publication-title: J. Endocrinol.
  doi: 10.1677/JOE-07-0277
– volume: 2018
  start-page: 2464652
  year: 2018
  ident: ref_203
  article-title: Adipocyte DIO2 Expression Increases in Human Obesity but Is Not Related to Systemic Insulin Sensitivity
  publication-title: J. Diabetes Res.
  doi: 10.1155/2018/2464652
– volume: 326
  start-page: 139
  year: 2006
  ident: ref_162
  article-title: Mechanism of plasma glutathione peroxidase production in bovine adipocytes
  publication-title: Cell Tissue Res.
  doi: 10.1007/s00441-006-0194-4
– volume: 5
  start-page: 259
  year: 2006
  ident: ref_85
  article-title: Effect of weight loss with or without orlistat treatment on adipocytokines, inflammation, and oxidative markers in obese women
  publication-title: Horm. Athens
  doi: 10.14310/horm.2002.11190
– volume: 23
  start-page: 990.13
  year: 2009
  ident: ref_150
  article-title: Adipose Expression and Regulation of Selenoprotein P in Obesity and Insulin Resistance
  publication-title: FASEB J.
– volume: 19
  start-page: 720
  year: 2019
  ident: ref_3
  article-title: Redox-active selenium in health and disease: A conceptual review
  publication-title: Mini Rev. Med. Chem.
  doi: 10.2174/1389557517666161104125022
– volume: 175
  start-page: 367
  year: 2017
  ident: ref_129
  article-title: Early high-fat feeding induces alteration of trace element content in tissues of juvenile male Wistar rats
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-016-0777-1
– volume: 41
  start-page: 1615
  year: 2000
  ident: ref_144
  article-title: Identification of genes specifically expressed in the accumulated visceral adipose tissue of OLETF rats
  publication-title: J. Lipid Res.
  doi: 10.1016/S0022-2275(20)31994-5
– volume: 60
  start-page: 114
  year: 2011
  ident: ref_159
  article-title: Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors
  publication-title: Metabolism
  doi: 10.1016/j.metabol.2010.05.011
– volume: 65
  start-page: 1538
  year: 2013
  ident: ref_21
  article-title: Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2013.07.016
– volume: 144
  start-page: 232
  year: 2014
  ident: ref_137
  article-title: Uptake of 25-hydroxyvitamin D by muscle and fat cells
  publication-title: J. Steroid Biochem. Mol. Biol.
  doi: 10.1016/j.jsbmb.2013.10.020
– ident: ref_259
  doi: 10.1002/9783527694907
– volume: 112
  start-page: 14018
  year: 2015
  ident: ref_208
  article-title: Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1508943112
– volume: 1823
  start-page: 1633
  year: 2012
  ident: ref_4
  article-title: Understanding selenoprotein function and regulation through the use of rodent models
  publication-title: BBA Mol. Cell Res.
– volume: 60
  start-page: 1082
  year: 2011
  ident: ref_207
  article-title: Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality
  publication-title: Diabetes
  doi: 10.2337/db10-0758
– volume: 108
  start-page: 57
  year: 2012
  ident: ref_89
  article-title: Histidine and arginine are associated with inflammation and oxidative stress in obese women
  publication-title: Br. J. Nutr.
  doi: 10.1017/S0007114511005289
– volume: 127
  start-page: 1
  year: 2018
  ident: ref_1
  article-title: Selenium and selenoproteins in (redox) signaling, diseases, and animal models-200 year anniversary issue
  publication-title: Free Radic Biol. Med.
  doi: 10.1016/j.freeradbiomed.2018.09.026
– volume: 7
  start-page: e7352
  year: 2019
  ident: ref_29
  article-title: Comprehensive map and functional annotation of the mouse white adipose tissue proteome
  publication-title: Peer J.
  doi: 10.7717/peerj.7352
– volume: 59
  start-page: 1015
  year: 2018
  ident: ref_46
  article-title: EPT1 (selenoprotein I) is critical for the neural development and maintenance of plasmalogen in humans
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.P081620
– volume: 171
  start-page: 399
  year: 2016
  ident: ref_114
  article-title: Effects of selenium-enriched probiotics on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in mice fed a high-fat diet
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-015-0552-8
– volume: 75
  start-page: 1567
  year: 2018
  ident: ref_187
  article-title: The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: Towards a possible prognostic marker?
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-018-2745-8
– volume: 19
  start-page: 958
  year: 2013
  ident: ref_38
  article-title: The methionine sulfoxide reduction system: Selenium utilization and methionine sulfoxide reductase enzymes and their functions
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2012.5081
– volume: 17
  start-page: 33
  year: 2015
  ident: ref_113
  article-title: Dietary selenate attenuates adiposity and improves insulin sensitivity in high-fat diet-induced obese mice
  publication-title: J. Funct. Foods
  doi: 10.1016/j.jff.2015.05.008
– volume: 1355
  start-page: 259
  year: 1997
  ident: ref_122
  article-title: Selenium: Potent stimulator of tyrosyl phosphorylation and activator of MAP kinase
  publication-title: BBA Mol. Cell Res.
– volume: 8
  start-page: e26
  year: 2014
  ident: ref_70
  article-title: Impaired enzymatic antioxidant defense in erythrocytes of women with general and abdominal obesity
  publication-title: Obes. Res. Clin. Pract.
  doi: 10.1016/j.orcp.2012.07.004
– volume: 25
  start-page: 479
  year: 2007
  ident: ref_78
  article-title: Oxidative status and serum leptin levels in obese prepubertal children
  publication-title: Cell Biochem. Funct. Cell. Biochem. Modul. Act. Agents Dis.
– volume: 19
  start-page: 1
  year: 2019
  ident: ref_16
  article-title: Selenium intake, status, and health: A complex relationship
  publication-title: Hormones
– volume: 301
  start-page: 280
  year: 2004
  ident: ref_136
  article-title: High extracellular calcium attenuates adipogenesis in 3T3-L1 preadipocytes
  publication-title: Exp. Cell Res.
  doi: 10.1016/j.yexcr.2004.08.030
– volume: 16
  start-page: 2601
  year: 2008
  ident: ref_227
  article-title: Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients
  publication-title: Obesity
  doi: 10.1038/oby.2008.419
– ident: ref_11
  doi: 10.1007/978-981-13-2529-8
– volume: 375
  start-page: 139
  year: 2013
  ident: ref_139
  article-title: The cloning, characterization, and expression profiling of the LRP8 gene in duck (Anas platyrhynchos)
  publication-title: Mol. Cell. Biochem.
– volume: 14
  start-page: 383
  year: 2011
  ident: ref_184
  article-title: Impacts of dietary selenium deficiency on metabolic phenotypes of diet-restricted gpx1-overexpressing mice
  publication-title: Antioxid. Redox. Signal.
  doi: 10.1089/ars.2010.3295
– volume: 9
  start-page: 4521
  year: 2010
  ident: ref_160
  article-title: Characterization of the human adipocyte proteome and reproducibility of protein abundance by one-dimensional gel electrophoresis and HPLC−ESI−MS/MS
  publication-title: J. Proteome Res.
  doi: 10.1021/pr100268f
– volume: 10
  start-page: 141
  year: 2019
  ident: ref_166
  article-title: Oxidative stress mediates depot-specific functional differences of human adipose-derived stem cells
  publication-title: Stem Cell Res. Ther.
  doi: 10.1186/s13287-019-1240-y
– volume: 12
  start-page: 793
  year: 2010
  ident: ref_2
  article-title: Selenium and selenoproteins in health and disease
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2009.2973
– volume: 143
  start-page: 787
  year: 2011
  ident: ref_74
  article-title: Parameters of metabolic syndrome and its relationship with zincemia and activities of superoxide dismutase and glutathione peroxidase in obese women
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-010-8940-6
– volume: 35
  start-page: 221
  year: 2002
  ident: ref_242
  article-title: Selenium supplementation and GSH-Px activity in the IBAT and erythrocytes of cold-adapted rats
  publication-title: Food Res. Int.
  doi: 10.1016/S0963-9969(01)00188-0
– volume: 26
  start-page: 1007
  year: 2019
  ident: ref_158
  article-title: Degradation of selenoprotein S and selenoprotein K through PPARγ-mediated ubiquitination is required for adipocyte differentiation
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-018-0180-x
– volume: 16
  start-page: 149
  year: 2011
  ident: ref_191
  article-title: Differential redox potential profiles during adipogenesis and osteogenesis
  publication-title: Cell Mol. Biol. Lett.
  doi: 10.2478/s11658-010-0042-0
– volume: 265
  start-page: 1124
  year: 1990
  ident: ref_121
  article-title: The insulin-like effects of selenate in rat adipocytes
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)40166-X
– volume: 155
  start-page: 255
  year: 1997
  ident: ref_241
  article-title: Selenium and iodine deficiencies: Effects on brain and brown adipose tissue selenoenzyme activity and expression
  publication-title: J. Endocrinol.
  doi: 10.1677/joe.0.1550255
– volume: 10
  start-page: 540
  year: 2014
  ident: ref_54
  article-title: Nutrient deficiencies in patients with obesity considering bariatric surgery: A cross-sectional study
  publication-title: Surg. Obes. Relat. Dis.
  doi: 10.1016/j.soard.2013.10.003
– volume: 7
  start-page: 112
  year: 2008
  ident: ref_71
  article-title: Serum selenium and glutathione peroxidase in patients with obesity and metabolic syndrome
  publication-title: Pak. J. Nutr.
– volume: 415
  start-page: 89
  year: 2016
  ident: ref_117
  article-title: Differential effect of Se on insulin resistance: Regulation of adipogenesis and lipolysis
  publication-title: Mol. Cell. Biochem.
  doi: 10.1007/s11010-016-2679-0
– volume: 59
  start-page: 1181
  year: 2005
  ident: ref_55
  article-title: Serum concentrations of β-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population
  publication-title: Eur. J. Clin. Nutr.
  doi: 10.1038/sj.ejcn.1602230
– volume: 82
  start-page: 121
  year: 2012
  ident: ref_51
  article-title: Young children with excess of weight show an impaired selenium status
  publication-title: Int. J. Vitam. Nutr. Res.
  doi: 10.1024/0300-9831/a000101
– volume: 5
  start-page: eaav0198
  year: 2019
  ident: ref_232
  article-title: SBP2 deficiency in adipose tissue macrophages drives insulin resistance in obesity
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.aav0198
– volume: 59
  start-page: 126470
  year: 2020
  ident: ref_58
  article-title: High serum concentration of selenium, but not calcium, cobalt, copper, iron, and magnesium, increased the risk of both hyperglycemia and dyslipidemia in adults: A health examination center based cross-sectional study
  publication-title: J. Trace Elem. Med. Biol.
  doi: 10.1016/j.jtemb.2020.126470
– volume: 44
  start-page: 336
  year: 2014
  ident: ref_104
  article-title: Selenium improves stem cell potency by stimulating the proliferation and active migration of 3T3-L1 preadipocytes
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2013.2182
– volume: 114
  start-page: 47
  year: 2012
  ident: ref_126
  article-title: Supranutritional selenium induces alterations in molecular targets related to energy metabolism in skeletal muscle and visceral adipose tissue of pigs
  publication-title: J. Inorg. Biochem.
  doi: 10.1016/j.jinorgbio.2012.04.011
– volume: 51
  start-page: 1515
  year: 2008
  ident: ref_179
  article-title: Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice
  publication-title: Diabetologia
  doi: 10.1007/s00125-008-1055-3
– volume: 5
  start-page: 479
  year: 2014
  ident: ref_200
  article-title: Adipose tissues and thyroid hormones
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2014.00479
– volume: 11
  start-page: 447
  year: 2013
  ident: ref_108
  article-title: Anti-obese Function of Selenate, An Essential Micronutrient, by Regulation of Adipogenesis in C3H10T1/2 Cells
  publication-title: Korean J. Aesthet. Cosmetol.
– volume: 40
  start-page: 524
  year: 2014
  ident: ref_56
  article-title: Gender-specific distribution of selenium to serum selenoproteins: Associations with total selenium levels, age, smoking, body mass index, and physical activity
  publication-title: Biofactors
  doi: 10.1002/biof.1176
– volume: 40
  start-page: 83
  year: 2015
  ident: ref_79
  article-title: Visfatin and oxidative stress influence endothelial progenitor cells in obese populations
  publication-title: Endocr. Res.
  doi: 10.3109/07435800.2014.952016
– volume: 38
  start-page: 1497
  year: 2014
  ident: ref_97
  article-title: Levels of circulating selenoprotein P, fibroblast growth factor (FGF) 21 and FGF23 in relation to the metabolic syndrome in young children
  publication-title: Int. J. Obes.
  doi: 10.1038/ijo.2014.45
– ident: ref_213
– volume: 127
  start-page: 172
  year: 2018
  ident: ref_244
  article-title: Hypothalamic redox balance and leptin signaling-emerging role of selenoproteins
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2018.02.038
– volume: 63
  start-page: 162
  year: 2019
  ident: ref_67
  article-title: Consumption of Brazil nuts with high selenium levels increased inflammation biomarkers in obese women: A randomized controlled trial
  publication-title: Nutrition
  doi: 10.1016/j.nut.2019.02.009
– ident: ref_45
  doi: 10.1371/journal.pone.0095518
– volume: 2
  start-page: 72
  year: 2011
  ident: ref_86
  article-title: Glutathione peroxidase activity in obese and nonobese diabetic patients and role of hyperglycemia in oxidative stress
  publication-title: J. Mid Life Health
  doi: 10.4103/0976-7800.92529
– volume: 19
  start-page: 24
  year: 2019
  ident: ref_87
  article-title: Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity
  publication-title: Mol. Metab.
  doi: 10.1016/j.molmet.2018.10.005
– volume: 21
  start-page: 305
  year: 2011
  ident: ref_198
  article-title: Type 2 iodothyronine deiodinase is expressed in human preadipocytes
  publication-title: Thyroid
  doi: 10.1089/thy.2010.0068
– ident: ref_14
  doi: 10.1007/978-3-319-41283-2
– volume: 536
  start-page: 152
  year: 2013
  ident: ref_9
  article-title: Selenium homeostasis and antioxidant selenoproteins in brain: Implications for disorders in the central nervous system
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1016/j.abb.2013.02.021
– ident: ref_260
  doi: 10.1007/978-3-319-41283-2
– volume: 45
  start-page: 1052
  year: 2011
  ident: ref_222
  article-title: Obesity reduces methionine sulphoxide reductase activity in visceral adipose tissue
  publication-title: Free Radic. Res.
  doi: 10.3109/10715762.2011.591793
– volume: 142
  start-page: 1975
  year: 2012
  ident: ref_185
  article-title: Dietary selenium deficiency partially rescues type 2 diabetes-like phenotypes of glutathione peroxidase-1-overexpressing male mice
  publication-title: J. Nutr.
  doi: 10.3945/jn.112.164764
– volume: 3
  start-page: nzz044-P24
  year: 2019
  ident: ref_235
  article-title: RNA-Seq Analysis in Liver of Selenium-deficient Selenocysteine Lyase Knockout Mouse
  publication-title: Curr. Dev. Nutr.
  doi: 10.1093/cdn/nzz044.P24-023-19
– volume: 151
  start-page: 298
  year: 2015
  ident: ref_249
  article-title: Evidence for the contribution of multiple mechanisms in the feeding pattern of rats exposed to p-chloro-diphenyl diselenide-supplemented diets
  publication-title: Physiol. Behav.
  doi: 10.1016/j.physbeh.2015.07.029
– volume: 56
  start-page: 69
  year: 2019
  ident: ref_215
  article-title: Selenium and iodine in diabetes mellitus with a focus on the interplay and speciation of the elements
  publication-title: J. Trace Elem. Med. Biol.
  doi: 10.1016/j.jtemb.2019.07.005
– volume: 43
  start-page: 106
  year: 2017
  ident: ref_60
  article-title: The influence of selenium status on body composition, oxidative DNA damage and total antioxidant capacity in newly diagnosed type 2 diabetes mellitus: A case-control study
  publication-title: J. Trace Elem. Med. Biol.
  doi: 10.1016/j.jtemb.2016.12.009
– volume: 33
  start-page: 789
  year: 2018
  ident: ref_20
  article-title: Selenium exposure and the risk of type 2 diabetes: A systematic review and meta-analysis
  publication-title: Eur. J. Epidemiol.
  doi: 10.1007/s10654-018-0422-8
– volume: 37
  start-page: 63
  year: 2013
  ident: ref_100
  article-title: Increased selenoprotein p levels in subjects with visceral obesity and nonalcoholic Fatty liver disease
  publication-title: Diabetes Metab.
  doi: 10.4093/dmj.2013.37.1.63
– volume: 14
  start-page: 1263
  year: 2009
  ident: ref_118
  article-title: Selenium as an essential micronutrient: Roles in cell cycle and apoptosis
  publication-title: Molecules
  doi: 10.3390/molecules14031263
– volume: 66
  start-page: 836
  year: 2015
  ident: ref_134
  article-title: Deficiency of angiotensinogen in hepatocytes markedly decreases blood pressure in lean and obese male mice
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.115.06040
– ident: ref_12
  doi: 10.1016/j.semarthrit.2019.07.014
– volume: 286
  start-page: 30433
  year: 2011
  ident: ref_192
  article-title: Increased Adipocyte S-Nitrosylation Targets Anti-lipolytic Action of Insulin Relevance to Adipose Tissue Dysfunction in Obesity
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.235945
– volume: 5
  start-page: 192
  year: 2006
  ident: ref_84
  article-title: Plasma interleukin-6 levels, glutathione peroxidase and isoprostane in obese women before and after weight loss. Association with cardiovascular risk factors
  publication-title: Horm. Athens
  doi: 10.14310/horm.2002.11182
– volume: 25
  start-page: 392
  year: 2009
  ident: ref_66
  article-title: Association of retinol-binding protein-4 with dietary selenium intake and other lifestyle features in young healthy women
  publication-title: Nutrition
  doi: 10.1016/j.nut.2008.09.015
– volume: 17
  start-page: 141
  year: 2013
  ident: ref_237
  article-title: Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2012.12.007
– volume: 25
  start-page: 2492
  year: 2011
  ident: ref_15
  article-title: Dietary selenium affects host selenoproteome expression by influencing the gut microbiota
  publication-title: FASEB J.
  doi: 10.1096/fj.11-181990
– volume: 192
  start-page: 1
  year: 2019
  ident: ref_157
  article-title: From Selenium Absorption to Selenoprotein Degradation
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-019-01771-x
– ident: ref_32
  doi: 10.1007/978-0-387-89382-2
– volume: 190
  start-page: 537
  year: 2006
  ident: ref_211
  article-title: Differential effects of leptin and refeeding on the fasting-induced decrease of pituitary type 2 deiodinase and thyroid hormone receptor β2 mRNA expression in mice
  publication-title: J. Endocrinol.
  doi: 10.1677/joe.1.06872
– volume: 31
  start-page: 157
  year: 2015
  ident: ref_13
  article-title: Selenium and coenzyme Q10 interrelationship in cardiovascular diseases–a clinician’s point of view
  publication-title: J. Trace Elem. Med. Biol.
  doi: 10.1016/j.jtemb.2014.11.006
– ident: ref_246
– volume: 356
  start-page: 233
  year: 2000
  ident: ref_10
  article-title: The importance of selenium to human health
  publication-title: Lancet
  doi: 10.1016/S0140-6736(00)02490-9
– volume: 25
  start-page: 261
  year: 2012
  ident: ref_83
  article-title: Oxidative stress in obese children and its relation with insulin resistance
  publication-title: J. Pediatr. Endocrinol. Meta
– ident: ref_5
  doi: 10.3390/nu10091203
– ident: ref_233
  doi: 10.3390/antiox8090357
– volume: 4
  start-page: 493
  year: 2015
  ident: ref_183
  article-title: Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
  publication-title: Mol. Metab.
  doi: 10.1016/j.molmet.2015.04.001
– volume: 31
  start-page: 167
  year: 2015
  ident: ref_53
  article-title: Copper, selenium and zinc levels after bariatric surgery in patients recommended to take multivitamin-mineral supplementation
  publication-title: J. Trace Elem. Med. Biol.
  doi: 10.1016/j.jtemb.2014.09.005
– volume: 36
  start-page: 320
  year: 2012
  ident: ref_201
  article-title: Type I iodothyronine 5′-deiodinase mRNA and activity is increased in adipose tissue of obese subjects
  publication-title: Int. J. Obes.
  doi: 10.1038/ijo.2011.101
– volume: 286
  start-page: 241
  year: 2019
  ident: ref_43
  article-title: Endoplasmic reticulum stress signalling–from basic mechanisms to clinical applications
  publication-title: FEBS J.
  doi: 10.1111/febs.14608
– volume: 70
  start-page: 76
  year: 2018
  ident: ref_33
  article-title: Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis
  publication-title: Cell Calcium
  doi: 10.1016/j.ceca.2017.05.001
– volume: 20
  start-page: 191
  year: 2014
  ident: ref_186
  article-title: Novel regulation and signaling of glucose-stimulated insulin secretion in islets by Se-glutathione peroxidase-1 mimic ebselen
  publication-title: Antioxid. Redox. Signal.
  doi: 10.1089/ars.2013.5361
– volume: 174
  start-page: 32
  year: 2016
  ident: ref_57
  article-title: Trace element alterations in the hair of diabetic and obese women
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-016-0691-6
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Snippet Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its possible roles in obesity development and in adipocyte metabolism...
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SubjectTerms adipocyte
Adipocytes
Adipogenesis
Adipose tissue
Adipose Tissue - metabolism
Adipose Tissue - physiology
Analysis
Animals
Bioavailability
Biomarkers
Biosynthesis
Body fat
Body mass index
Cancer
Carbohydrate metabolism
Cytoplasm
Diabetes
Disease
Endoplasmic reticulum
Glutathione
Glutathione peroxidase
Homeostasis
Humans
Influence
Insulin
Insulin resistance
Lipid metabolism
Lipolysis
Metabolism
Metabolites
Microbiota
Neurodegeneration
Obesity
Obesity - blood
Obesity - metabolism
Pathogenesis
Physiological aspects
Physiology
Proteins
Review
Reviews
Selenium
Selenium (Nutrient)
Selenium - metabolism
selenoprotein
Selenoproteins
Selenoproteins - blood
Selenoproteins - metabolism
Signal Transduction
Supplements
Thioredoxin
Thyroid gland
Womens health
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Title Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity
URI https://www.ncbi.nlm.nih.gov/pubmed/32344656
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Volume 10
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