Stereotactic Body Radiation Therapy for Early-Stage Non–Small-Cell Lung Cancer: The Pattern of Failure Is Distant

• Published in: International journal of radiation oncology, biology, physics Vol. 77; no. 4; pp. 1146 - 1150
• Main Authors: Bradley, Jeffrey D., M.D, El Naqa, Issam, Ph.D, Drzymala, Robert E., Ph.D, Trovo, Marco, M.D, Jones, Griffin, Denning, Mary Dee, R.N
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.07.2010; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Analysis of Variance; Biological and medical sciences; BODY; Bronchus; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - secondary; Carcinoma, Non-Small-Cell Lung - surgery; DISEASES; Dose Fractionation; DOSES; FAILURES; Female; Follow-Up Studies; Hematology, Oncology and Palliative Medicine; Humans; Lung cancer; Lung Neoplasms - pathology; Lung Neoplasms - surgery; LUNGS; Male; Medical sciences; MEDICINE; METASTASES; Middle Aged; Neoplasm Staging - methods; NEOPLASMS; Neoplasms, Second Primary - etiology; NUCLEAR MEDICINE; ORGANS; Pneumology; Proportional Hazards Models; Radiation dose; RADIATION DOSES; RADIOLOGY; RADIOLOGY AND NUCLEAR MEDICINE; Radiosurgery - adverse effects; Radiosurgery - methods; RADIOTHERAPY; RESPIRATORY SYSTEM; SBRT; Stereotactic radiation therapy; THERAPY; Treatment Failure; Tumor Burden; Tumors of the respiratory system and mediastinum; Radiation dose; Lung cancer; Stereotactic radiation therapy; SBRT; Lung disease; Respiratory disease; Early stage; Stereotaxia; Malignant tumor; non-small cell lung carcinoma; Radiotherapy; Treatment; Bronchus disease; Failure; Cancer

Background Stereotactic body radiation therapy (SBRT) represents a substantial paradigm shift in the treatment of patients with medically inoperable Stage I/II non–small-cell lung cancer. We reviewed our experience using either three- or five-fraction SBRT for peripheral or central tumors, respectiv...