Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
TDP-43 is a RNA-binding protein that forms inclusion bodies in ALS. The authors show that TDP-43 preferentially binds long clusters of UG-rich sequences and that TDP-43 binding on pre-mRNAs influences alternative splicing. Many alternative mRNA isoforms regulated by TDP-43 encode proteins that regul...
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| Published in | Nature neuroscience Vol. 14; no. 4; pp. 452 - 458 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.04.2011
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1097-6256 1546-1726 1546-1726 |
| DOI | 10.1038/nn.2778 |
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| Abstract | TDP-43 is a RNA-binding protein that forms inclusion bodies in ALS. The authors show that TDP-43 preferentially binds long clusters of UG-rich sequences and that TDP-43 binding on pre-mRNAs influences alternative splicing. Many alternative mRNA isoforms regulated by TDP-43 encode proteins that regulate neuronal development or are implicated in neurological diseases.
TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The mRNA targets of TDP-43 in the human brain and its role in RNA processing are largely unknown. Using individual nucleotide-resolution ultraviolet cross-linking and immunoprecipitation (iCLIP), we found that TDP-43 preferentially bound long clusters of UG-rich sequences
in vivo
. Analysis of RNA binding by TDP-43 in brains from subjects with FTLD revealed that the greatest increases in binding were to the MALAT1 and NEAT1 noncoding RNAs. We also found that binding of TDP-43 to pre-mRNAs influenced alternative splicing in a similar position-dependent manner to Nova proteins. In addition, we identified unusually long clusters of TDP-43 binding at deep intronic positions downstream of silenced exons. A substantial proportion of alternative mRNA isoforms regulated by TDP-43 encode proteins that regulate neuronal development or have been implicated in neurological diseases, highlighting the importance of TDP-43 for the regulation of splicing in the brain. |
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| AbstractList | TDP-43 is a RNA-binding protein that forms inclusion bodies in ALS. The authors show that TDP-43 preferentially binds long clusters of UG-rich sequences and that TDP-43 binding on pre-mRNAs influences alternative splicing. Many alternative mRNA isoforms regulated by TDP-43 encode proteins that regulate neuronal development or are implicated in neurological diseases.
TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The mRNA targets of TDP-43 in the human brain and its role in RNA processing are largely unknown. Using individual nucleotide-resolution ultraviolet cross-linking and immunoprecipitation (iCLIP), we found that TDP-43 preferentially bound long clusters of UG-rich sequences
in vivo
. Analysis of RNA binding by TDP-43 in brains from subjects with FTLD revealed that the greatest increases in binding were to the MALAT1 and NEAT1 noncoding RNAs. We also found that binding of TDP-43 to pre-mRNAs influenced alternative splicing in a similar position-dependent manner to Nova proteins. In addition, we identified unusually long clusters of TDP-43 binding at deep intronic positions downstream of silenced exons. A substantial proportion of alternative mRNA isoforms regulated by TDP-43 encode proteins that regulate neuronal development or have been implicated in neurological diseases, highlighting the importance of TDP-43 for the regulation of splicing in the brain. TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The mRNA targets of TDP-43 in the human brain and its role in RNA processing are largely unknown. Using individual nucleotide-resolution ultraviolet cross-linking and immunoprecipitation (iCLIP), we found that TDP-43 preferentially bound long clusters of UG-rich sequences in vivo. Analysis of RNA binding by TDP-43 in brains from subjects with FTLD revealed that the greatest increases in binding were to the MALAT1 and NEAT1 noncoding RNAs. We also found that binding of TDP-43 to pre-mRNAs influenced alternative splicing in a similar position-dependent manner to Nova proteins. In addition, we identified unusually long clusters of TDP-43 binding at deep intronic positions downstream of silenced exons. A substantial proportion of alternative mRNA isoforms regulated by TDP-43 encode proteins that regulate neuronal development or have been implicated in neurological diseases, highlighting the importance of TDP-43 for the regulation of splicing in the brain. TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The mRNA targets of TDP-43 in the human brain and its role in RNA processing are largely unknown. Using individual nucleotide-resolution ultraviolet cross-linking and immunoprecipitation (iCLIP), we found that TDP-43 preferentially bound long clusters of UG-rich sequences in vivo. Analysis of RNA binding by TDP-43 in brains from subjects with FTLD revealed that the greatest increases in binding were to the MALAT1 and NEAT1 noncoding RNAs. We also found that binding of TDP-43 to pre-mRNAs influenced alternative splicing in a similar position-dependent manner to Nova proteins. In addition, we identified unusually long clusters of TDP-43 binding at deep intronic positions downstream of silenced exons. A substantial proportion of alternative mRNA isoforms regulated by TDP-43 encode proteins that regulate neuronal development or have been implicated in neurological diseases, highlighting the importance of TDP-43 for the regulation of splicing in the brain.TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The mRNA targets of TDP-43 in the human brain and its role in RNA processing are largely unknown. Using individual nucleotide-resolution ultraviolet cross-linking and immunoprecipitation (iCLIP), we found that TDP-43 preferentially bound long clusters of UG-rich sequences in vivo. Analysis of RNA binding by TDP-43 in brains from subjects with FTLD revealed that the greatest increases in binding were to the MALAT1 and NEAT1 noncoding RNAs. We also found that binding of TDP-43 to pre-mRNAs influenced alternative splicing in a similar position-dependent manner to Nova proteins. In addition, we identified unusually long clusters of TDP-43 binding at deep intronic positions downstream of silenced exons. A substantial proportion of alternative mRNA isoforms regulated by TDP-43 encode proteins that regulate neuronal development or have been implicated in neurological diseases, highlighting the importance of TDP-43 for the regulation of splicing in the brain. |
| Audience | Academic |
| Author | Hortobágyi, Tibor Zupan, Blaž König, Julian Briese, Michael Rot, Gregor Ule, Jernej Patani, Rickie Curk, Tomaž Shaw, Christopher E Tollervey, James R Rogelj, Boris Nishimura, Agnes L Cereda, Matteo Župunski, Vera Chandran, Siddharthan Kayikci, Melis |
| Author_xml | – sequence: 1 givenname: James R surname: Tollervey fullname: Tollervey, James R organization: Medical Research Council (MRC) Laboratory of Molecular Biology – sequence: 2 givenname: Tomaž surname: Curk fullname: Curk, Tomaž organization: Faculty of Computer and Information Science, University of Ljubljana – sequence: 3 givenname: Boris surname: Rogelj fullname: Rogelj, Boris organization: MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry – sequence: 4 givenname: Michael surname: Briese fullname: Briese, Michael organization: Medical Research Council (MRC) Laboratory of Molecular Biology – sequence: 5 givenname: Matteo surname: Cereda fullname: Cereda, Matteo organization: Medical Research Council (MRC) Laboratory of Molecular Biology, Scientific Institute IRCCS E. Medea – sequence: 6 givenname: Melis surname: Kayikci fullname: Kayikci, Melis organization: Medical Research Council (MRC) Laboratory of Molecular Biology – sequence: 7 givenname: Julian surname: König fullname: König, Julian organization: Medical Research Council (MRC) Laboratory of Molecular Biology – sequence: 8 givenname: Tibor surname: Hortobágyi fullname: Hortobágyi, Tibor organization: MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry – sequence: 9 givenname: Agnes L surname: Nishimura fullname: Nishimura, Agnes L organization: MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry – sequence: 10 givenname: Vera surname: Župunski fullname: Župunski, Vera organization: MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Faculty of Chemistry and Chemical Technology, University of Ljubljana – sequence: 11 givenname: Rickie surname: Patani fullname: Patani, Rickie organization: Department of Clinical Neurosciences, MRC Laboratory for Regenerative Medicine – sequence: 12 givenname: Siddharthan surname: Chandran fullname: Chandran, Siddharthan organization: Department of Clinical Neurosciences, MRC Laboratory for Regenerative Medicine, Centre for Clinical Brain Sciences, University of Edinburgh – sequence: 13 givenname: Gregor surname: Rot fullname: Rot, Gregor organization: Faculty of Computer and Information Science, University of Ljubljana – sequence: 14 givenname: Blaž surname: Zupan fullname: Zupan, Blaž organization: Faculty of Computer and Information Science, University of Ljubljana – sequence: 15 givenname: Christopher E surname: Shaw fullname: Shaw, Christopher E organization: MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry – sequence: 16 givenname: Jernej surname: Ule fullname: Ule, Jernej email: jule@mrc-lmb.cam.ac.uk organization: Medical Research Council (MRC) Laboratory of Molecular Biology |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21358640$$D View this record in MEDLINE/PubMed |
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| CODEN | NANEFN |
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| Cites_doi | 10.1371/journal.pbio.1000530 10.1074/jbc.M806250200 10.1073/pnas.0800546105 10.1016/j.mcn.2007.03.007 10.2741/2727 10.1016/j.molcel.2010.08.011 10.1016/j.bbrc.2009.03.038 10.1126/science.1154584 10.1093/emboj/17.2.384 10.1038/emboj.2010.310 10.1038/35097565 10.1016/j.molcel.2009.01.026 10.1093/hmg/ddq137 10.1074/jbc.M809462200 10.1146/annurev.biochem.72.121801.161720 10.1126/science.1134108 10.1093/oxfordjournals.molbev.a004023 10.1371/journal.pone.0012247 10.1073/pnas.0802082105 10.1016/j.cell.2010.01.017 10.1038/nsmb.1838 10.1074/jbc.M104236200 10.1016/j.tig.2006.03.005 10.1261/rna.725208 10.1126/science.1090095 10.1016/j.sbi.2008.04.002 10.1093/nar/gkp013 10.1074/jbc.M110.190884 10.1016/j.brainres.2006.04.132 10.4161/cc.6.11.4316 10.1111/j.1742-4658.2010.07643.x 10.1016/j.neuron.2009.09.026 10.1101/gr.6554007 10.1038/emboj.2009.324 10.1126/science.1166088 10.1016/j.tig.2010.12.001 10.1038/nn.2779 10.1002/dvg.20584 |
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| References | Voigt (CR9) 2010; 5 Igaz (CR7) 2009; 284 Buratti, Baralle (CR1) 2008; 13 Ayala (CR14) 2011; 30 Matter, Pribadi, Liu, Trachtenberg (CR31) 2009; 64 Tripathi (CR37) 2010; 39 Cléry, Blatter, Allain (CR23) 2008; 18 Strong (CR17) 2007; 35 Clemson (CR11) 2009; 33 Ness (CR35) 2006; 1099 Wang (CR38) 2010; 8 CR15 Kametani (CR20) 2009; 382 Buratti (CR19) 2010; 277 Fiesel (CR21) 2010; 29 Hung (CR26) 2008; 14 Ayala, Misteli, Baralle (CR18) 2008; 105 Wu (CR30) 2010; 48 Kuo, Doudeva, Wang, Shen, Yuan (CR2) 2009; 37 Ishiyama (CR32) 2010; 141 Black (CR25) 2003; 72 Sephton (CR16) 2011; 286 Rockman, Wray (CR27) 2002; 19 König (CR10) 2010; 17 Yang (CR34) 2009; 323 Johnson, McCaffery, Lindquist, Gitler (CR8) 2008; 105 Buratti, Baralle (CR3) 2001; 276 Cleveland, Rothstein (CR12) 2001; 2 Legendre, Pochet, Pak, Verstrepen (CR29) 2007; 17 O'Connor (CR22) 1998; 17 CR24 Kashi, King (CR28) 2006; 22 Kouchi (CR33) 2009; 284 Lagier-Tourenne, Polymenidou, Cleveland (CR5) 2010; 19 Sreedharan (CR4) 2008; 319 Ule (CR13) 2003; 302 Neumann (CR6) 2006; 314 Becker, Bonni (CR36) 2007; 6 A Cléry (BFnn2778_CR23) 2008; 18 JM Ness (BFnn2778_CR35) 2006; 1099 BFnn2778_CR15 YM Ayala (BFnn2778_CR18) 2008; 105 J Sreedharan (BFnn2778_CR4) 2008; 319 CF Sephton (BFnn2778_CR16) 2011; 286 E Buratti (BFnn2778_CR1) 2008; 13 YM Ayala (BFnn2778_CR14) 2011; 30 MJ Strong (BFnn2778_CR17) 2007; 35 MV Rockman (BFnn2778_CR27) 2002; 19 J König (BFnn2778_CR10) 2010; 17 BS Johnson (BFnn2778_CR8) 2008; 105 Y Kashi (BFnn2778_CR28) 2006; 22 LH Hung (BFnn2778_CR26) 2008; 14 N Ishiyama (BFnn2778_CR32) 2010; 141 DW Cleveland (BFnn2778_CR12) 2001; 2 Z Wang (BFnn2778_CR38) 2010; 8 M Legendre (BFnn2778_CR29) 2007; 17 E Buratti (BFnn2778_CR3) 2001; 276 FC Fiesel (BFnn2778_CR21) 2010; 29 V Tripathi (BFnn2778_CR37) 2010; 39 J Ule (BFnn2778_CR13) 2003; 302 BFnn2778_CR24 E Buratti (BFnn2778_CR19) 2010; 277 A Voigt (BFnn2778_CR9) 2010; 5 Z Kouchi (BFnn2778_CR33) 2009; 284 DL Black (BFnn2778_CR25) 2003; 72 PH Kuo (BFnn2778_CR2) 2009; 37 EB Becker (BFnn2778_CR36) 2007; 6 C Lagier-Tourenne (BFnn2778_CR5) 2010; 19 F Kametani (BFnn2778_CR20) 2009; 382 LM Igaz (BFnn2778_CR7) 2009; 284 CM Clemson (BFnn2778_CR11) 2009; 33 C Matter (BFnn2778_CR31) 2009; 64 Q Yang (BFnn2778_CR34) 2009; 323 L O'Connor (BFnn2778_CR22) 1998; 17 M Neumann (BFnn2778_CR6) 2006; 314 LS Wu (BFnn2778_CR30) 2010; 48 21505508 - Nat Rev Neurosci. 2011 May;12(5):246. doi: 10.1038/nrn3032. 21445063 - Nat Neurosci. 2011 Apr;14(4):403-5. doi: 10.1038/nn.2784. |
| References_xml | – volume: 8 start-page: e1000530 year: 2010 ident: CR38 article-title: iCLIP predicts the dual splicing effects of TIA-RNA interactions publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1000530 – volume: 284 start-page: 1954 year: 2009 end-page: 1961 ident: CR33 article-title: p120 catenin recruits cadherins to gamma-secretase and inhibits production of Aβ peptide publication-title: J. Biol. Chem. doi: 10.1074/jbc.M806250200 – volume: 105 start-page: 3785 year: 2008 end-page: 3789 ident: CR18 article-title: TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0800546105 – volume: 35 start-page: 320 year: 2007 end-page: 327 ident: CR17 article-title: TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein publication-title: Mol. Cell. Neurosci. doi: 10.1016/j.mcn.2007.03.007 – volume: 13 start-page: 867 year: 2008 end-page: 878 ident: CR1 article-title: Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease publication-title: Front. Biosci. doi: 10.2741/2727 – volume: 39 start-page: 925 year: 2010 end-page: 938 ident: CR37 article-title: The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.08.011 – volume: 382 start-page: 405 year: 2009 end-page: 409 ident: CR20 article-title: Identification of casein kinase-1 phosphorylation sites on TDP-43 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2009.03.038 – volume: 319 start-page: 1668 year: 2008 end-page: 1672 ident: CR4 article-title: TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis publication-title: Science doi: 10.1126/science.1154584 – volume: 17 start-page: 384 year: 1998 end-page: 395 ident: CR22 article-title: Bim: a novel member of the Bcl-2 family that promotes apoptosis publication-title: EMBO J. doi: 10.1093/emboj/17.2.384 – volume: 30 start-page: 277 year: 2011 end-page: 288 ident: CR14 article-title: TDP-43 regulates its mRNA levels through a negative feedback loop publication-title: EMBO J. doi: 10.1038/emboj.2010.310 – volume: 2 start-page: 806 year: 2001 end-page: 819 ident: CR12 article-title: From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS publication-title: Nat. Rev. Neurosci. doi: 10.1038/35097565 – volume: 33 start-page: 717 year: 2009 end-page: 726 ident: CR11 article-title: An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles publication-title: Mol. Cell doi: 10.1016/j.molcel.2009.01.026 – volume: 19 start-page: R46 year: 2010 end-page: R64 ident: CR5 article-title: TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddq137 – volume: 284 start-page: 8516 year: 2009 end-page: 8524 ident: CR7 article-title: Expression of TDP-43 C-terminal fragments recapitulates pathological features of TDP-43 proteinopathies publication-title: J. Biol. Chem. doi: 10.1074/jbc.M809462200 – volume: 72 start-page: 291 year: 2003 end-page: 336 ident: CR25 article-title: Mechanisms of alternative pre-messenger RNA splicing publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.biochem.72.121801.161720 – volume: 314 start-page: 130 year: 2006 end-page: 133 ident: CR6 article-title: Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis publication-title: Science doi: 10.1126/science.1134108 – volume: 19 start-page: 1991 year: 2002 end-page: 2004 ident: CR27 article-title: Abundant raw material for cis-regulatory evolution in humans publication-title: Mol. Biol. Evol. doi: 10.1093/oxfordjournals.molbev.a004023 – volume: 5 start-page: e12247 year: 2010 ident: CR9 article-title: TDP-43-mediated neuron loss requires RNA-binding activity publication-title: PLoS ONE doi: 10.1371/journal.pone.0012247 – volume: 105 start-page: 6439 year: 2008 end-page: 6444 ident: CR8 article-title: A yeast TDP-43 proteinopathy model: exploring the molecular determinants of TDP-43 aggregation and cellular toxicity publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0802082105 – volume: 141 start-page: 117 year: 2010 end-page: 128 ident: CR32 article-title: Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion publication-title: Cell doi: 10.1016/j.cell.2010.01.017 – volume: 17 start-page: 909 year: 2010 end-page: 915 ident: CR10 article-title: iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.1838 – volume: 48 start-page: 56 year: 2010 end-page: 62 ident: CR30 article-title: TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis publication-title: Genesis – ident: CR15 – volume: 276 start-page: 36337 year: 2001 end-page: 36343 ident: CR3 article-title: Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M104236200 – volume: 22 start-page: 253 year: 2006 end-page: 259 ident: CR28 article-title: Simple sequence repeats as advantageous mutators in evolution publication-title: Trends Genet. doi: 10.1016/j.tig.2006.03.005 – volume: 14 start-page: 284 year: 2008 end-page: 296 ident: CR26 article-title: Diverse roles of hnRNP L in mammalian mRNA processing: a combined microarray and RNAi analysis publication-title: RNA doi: 10.1261/rna.725208 – volume: 302 start-page: 1212 year: 2003 end-page: 1215 ident: CR13 article-title: CLIP identifies Nova-regulated RNA networks in the brain publication-title: Science doi: 10.1126/science.1090095 – volume: 18 start-page: 290 year: 2008 end-page: 298 ident: CR23 article-title: RNA recognition motifs: boring? Not quite publication-title: Curr. Opin. Struct. Biol. doi: 10.1016/j.sbi.2008.04.002 – volume: 37 start-page: 1799 year: 2009 end-page: 1808 ident: CR2 article-title: Structural insights into TDP-43 in nucleic-acid binding and domain interactions publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkp013 – volume: 286 start-page: 1204 year: 2011 end-page: 1215 ident: CR16 article-title: Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.190884 – volume: 1099 start-page: 150 year: 2006 end-page: 159 ident: CR35 article-title: Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia publication-title: Brain Res. doi: 10.1016/j.brainres.2006.04.132 – volume: 6 start-page: 1332 year: 2007 end-page: 1335 ident: CR36 article-title: Pin1 in neuronal apoptosis publication-title: Cell Cycle doi: 10.4161/cc.6.11.4316 – volume: 277 start-page: 2268 year: 2010 end-page: 2281 ident: CR19 article-title: Nuclear factor TDP-43 can affect selected microRNA levels publication-title: FEBS J. doi: 10.1111/j.1742-4658.2010.07643.x – volume: 64 start-page: 320 year: 2009 end-page: 327 ident: CR31 article-title: Delta-catenin is required for the maintenance of neural structure and function in mature cortex publication-title: Neuron doi: 10.1016/j.neuron.2009.09.026 – volume: 17 start-page: 1787 year: 2007 end-page: 1796 ident: CR29 article-title: Sequence-based estimation of minisatellite and microsatellite repeat variability publication-title: Genome Res. doi: 10.1101/gr.6554007 – ident: CR24 – volume: 29 start-page: 209 year: 2010 end-page: 221 ident: CR21 article-title: Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6 publication-title: EMBO J. doi: 10.1038/emboj.2009.324 – volume: 323 start-page: 124 year: 2009 end-page: 127 ident: CR34 article-title: Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy publication-title: Science doi: 10.1126/science.1166088 – volume: 19 start-page: R46 year: 2010 ident: BFnn2778_CR5 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddq137 – volume: 2 start-page: 806 year: 2001 ident: BFnn2778_CR12 publication-title: Nat. Rev. Neurosci. doi: 10.1038/35097565 – volume: 141 start-page: 117 year: 2010 ident: BFnn2778_CR32 publication-title: Cell doi: 10.1016/j.cell.2010.01.017 – volume: 29 start-page: 209 year: 2010 ident: BFnn2778_CR21 publication-title: EMBO J. doi: 10.1038/emboj.2009.324 – volume: 72 start-page: 291 year: 2003 ident: BFnn2778_CR25 publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.biochem.72.121801.161720 – volume: 18 start-page: 290 year: 2008 ident: BFnn2778_CR23 publication-title: Curr. Opin. Struct. Biol. doi: 10.1016/j.sbi.2008.04.002 – volume: 314 start-page: 130 year: 2006 ident: BFnn2778_CR6 publication-title: Science doi: 10.1126/science.1134108 – volume: 17 start-page: 384 year: 1998 ident: BFnn2778_CR22 publication-title: EMBO J. doi: 10.1093/emboj/17.2.384 – volume: 17 start-page: 1787 year: 2007 ident: BFnn2778_CR29 publication-title: Genome Res. doi: 10.1101/gr.6554007 – volume: 14 start-page: 284 year: 2008 ident: BFnn2778_CR26 publication-title: RNA doi: 10.1261/rna.725208 – volume: 19 start-page: 1991 year: 2002 ident: BFnn2778_CR27 publication-title: Mol. Biol. Evol. doi: 10.1093/oxfordjournals.molbev.a004023 – ident: BFnn2778_CR24 doi: 10.1016/j.tig.2010.12.001 – volume: 8 start-page: e1000530 year: 2010 ident: BFnn2778_CR38 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1000530 – volume: 319 start-page: 1668 year: 2008 ident: BFnn2778_CR4 publication-title: Science doi: 10.1126/science.1154584 – volume: 13 start-page: 867 year: 2008 ident: BFnn2778_CR1 publication-title: Front. Biosci. doi: 10.2741/2727 – volume: 284 start-page: 8516 year: 2009 ident: BFnn2778_CR7 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M809462200 – volume: 39 start-page: 925 year: 2010 ident: BFnn2778_CR37 publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.08.011 – volume: 284 start-page: 1954 year: 2009 ident: BFnn2778_CR33 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M806250200 – volume: 1099 start-page: 150 year: 2006 ident: BFnn2778_CR35 publication-title: Brain Res. doi: 10.1016/j.brainres.2006.04.132 – volume: 276 start-page: 36337 year: 2001 ident: BFnn2778_CR3 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M104236200 – ident: BFnn2778_CR15 doi: 10.1038/nn.2779 – volume: 302 start-page: 1212 year: 2003 ident: BFnn2778_CR13 publication-title: Science doi: 10.1126/science.1090095 – volume: 105 start-page: 6439 year: 2008 ident: BFnn2778_CR8 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0802082105 – volume: 48 start-page: 56 year: 2010 ident: BFnn2778_CR30 publication-title: Genesis doi: 10.1002/dvg.20584 – volume: 323 start-page: 124 year: 2009 ident: BFnn2778_CR34 publication-title: Science doi: 10.1126/science.1166088 – volume: 5 start-page: e12247 year: 2010 ident: BFnn2778_CR9 publication-title: PLoS ONE doi: 10.1371/journal.pone.0012247 – volume: 286 start-page: 1204 year: 2011 ident: BFnn2778_CR16 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.190884 – volume: 64 start-page: 320 year: 2009 ident: BFnn2778_CR31 publication-title: Neuron doi: 10.1016/j.neuron.2009.09.026 – volume: 105 start-page: 3785 year: 2008 ident: BFnn2778_CR18 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0800546105 – volume: 277 start-page: 2268 year: 2010 ident: BFnn2778_CR19 publication-title: FEBS J. doi: 10.1111/j.1742-4658.2010.07643.x – volume: 382 start-page: 405 year: 2009 ident: BFnn2778_CR20 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2009.03.038 – volume: 6 start-page: 1332 year: 2007 ident: BFnn2778_CR36 publication-title: Cell Cycle doi: 10.4161/cc.6.11.4316 – volume: 22 start-page: 253 year: 2006 ident: BFnn2778_CR28 publication-title: Trends Genet. doi: 10.1016/j.tig.2006.03.005 – volume: 17 start-page: 909 year: 2010 ident: BFnn2778_CR10 publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.1838 – volume: 33 start-page: 717 year: 2009 ident: BFnn2778_CR11 publication-title: Mol. Cell doi: 10.1016/j.molcel.2009.01.026 – volume: 37 start-page: 1799 year: 2009 ident: BFnn2778_CR2 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkp013 – volume: 35 start-page: 320 year: 2007 ident: BFnn2778_CR17 publication-title: Mol. Cell. Neurosci. doi: 10.1016/j.mcn.2007.03.007 – volume: 30 start-page: 277 year: 2011 ident: BFnn2778_CR14 publication-title: EMBO J. doi: 10.1038/emboj.2010.310 – reference: 21505508 - Nat Rev Neurosci. 2011 May;12(5):246. doi: 10.1038/nrn3032. – reference: 21445063 - Nat Neurosci. 2011 Apr;14(4):403-5. doi: 10.1038/nn.2784. |
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| Snippet | TDP-43 is a RNA-binding protein that forms inclusion bodies in ALS. The authors show that TDP-43 preferentially binds long clusters of UG-rich sequences and... TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis... |
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| SubjectTerms | 631/208/1792 631/208/200 631/378/2583 631/378/368/2430 Alternative Splicing - genetics Amyotrophic lateral sclerosis Analysis Animal Genetics and Genomics Bar codes Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain Brain Chemistry - genetics Brain research Cell Line Cell Line, Tumor DNA binding proteins DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Gene Expression Regulation - genetics Genetic aspects Genomes Humans Neurobiology Neurosciences Physiological aspects Protein Isoforms - genetics Proteins RNA RNA Splicing - physiology RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Untranslated - genetics RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism |
| Title | Characterizing the RNA targets and position-dependent splicing regulation by TDP-43 |
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