Predictors of contralateral prophylactic mastectomy in genetically high risk newly diagnosed breast cancer patients

• Published in: Breast cancer research and treatment Vol. 180; no. 1; pp. 177 - 185
• Main Authors: Tynan, Mara, Peshkin, Beth N., Isaacs, Claudine, Willey, Shawna, Valdimarsdottir, Heiddis B., Nusbaum, Rachel, Hooker, Gillian, O’Neill, Suzanne C., Jandorf, Lina, Kelly, Scott P., Heinzmann, Jessica, Kelleher, Sarah, Poggi, Elizabeth, Schwartz, Marc D.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2020; Springer; Springer Nature B.V
• Subjects: Adult; BRCA1 protein; Breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - genetics; Breast Neoplasms - surgery; Cancer patients; Cancer research; Care and treatment; Clinical Decision-Making; Combined Modality Therapy; Diagnosis; Disease Management; Epidemiology; Female; Genes, BRCA1; Genes, BRCA2; Genetic Counseling; Genetic Predisposition to Disease; Genetic Testing; Health aspects; Health risk assessment; Humans; Lumpectomy; Mastectomy; Medical colleges; Medical genetics; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Middle Aged; Multicenter Studies as Topic; Neoplasm Staging; Oncology; Patients; Prophylactic Mastectomy; Quality of Life; Randomized Controlled Trials as Topic; Risk factors; Surgery; Surveys; Treatment Outcome; Breast cancer; Genetic testing; Decision making; Contralateral prophylactic mastectomy

Purpose Recent trends indicate increased use of contralateral prophylactic mastectomy (CPM) among newly diagnosed breast cancer patients, particularly those who test positive for a pathogenic variant in the BRCA1/2 genes. However, the rate of CPM among patients who test negative or choose not to be...