A multicenter non-randomized, uncontrolled single arm trial for evaluation of the efficacy and the safety of the treatment with favipiravir for patients with severe fever with thrombocytopenia syndrome

• Published in: PLoS neglected tropical diseases Vol. 15; no. 2; p. e0009103
• Main Authors: Suemori, Koichiro, Saijo, Masayuki, Yamanaka, Atsushi, Himeji, Daisuke, Kawamura, Masafumi, Haku, Takashi, Hidaka, Michihiro, Kamikokuryo, Chinatsu, Kakihana, Yasuyuki, Azuma, Taichi, Takenaka, Katsuto, Takahashi, Toru, Furumoto, Akitsugu, Ishimaru, Toshiyuki, Ishida, Masayuki, Kaneko, Masahiko, Kadowaki, Norimitsu, Ikeda, Kenichi, Sakabe, Shigetoshi, Taniguchi, Tomohiro, Ohge, Hiroki, Kurosu, Takeshi, Yoshikawa, Tomoki, Shimojima, Masayuki, Yasukawa, Masaki
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.02.2021; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Drug therapy; Fever; Hyperthermia; Medicine and Health Sciences; Research and Analysis Methods; RNA virus infections; Thrombocytopenia; Japan

Severe fever with thrombocytopenia syndrome (SFTS) is a bunyavirus infection with high mortality. Favipiravir has shown effectiveness in preventing and treating SFTS virus (SFTSV) infection in animal models. A multicenter non-randomized, uncontrolled single arm trial was conducted to collect data on...