CD4+ T Responses Other Than Th1 Type Are Preferentially Induced by Latency-Associated Antigens in the State of Latent Mycobacterium tuberculosis Infection

( ) produces a diverse range of antigenic proteins in its dormant phase. The cytokine profiles of CD4 T cell responses, especially subsets other than Th1 type (non-Th1 type), against these latency-associated antigens such as α-crystallin (Acr), heparin-binding hemagglutinin (HBHA), and mycobacterial...

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Published inFrontiers in immunology Vol. 10; p. 2807
Main Authors Yamashita, Yoshiro, Oe, Toshiyuki, Kawakami, Kenji, Osada-Oka, Mayuko, Ozeki, Yuriko, Terahara, Kazutaka, Yasuda, Ikkoh, Edwards, Tansy, Tanaka, Takeshi, Tsunetsugu-Yokota, Yasuko, Matsumoto, Sohkichi, Ariyoshi, Koya
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 29.11.2019
Subjects
Acr
CD4+ T cells
HBHA
Immunology
latent M. tuberculosis infection
MDP-1
non-Th1
MDP-1
Acr
latent M. tuberculosis infection
HBHA
CD4+ T cells
non-Th1
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Abstract ( ) produces a diverse range of antigenic proteins in its dormant phase. The cytokine profiles of CD4 T cell responses, especially subsets other than Th1 type (non-Th1 type), against these latency-associated antigens such as α-crystallin (Acr), heparin-binding hemagglutinin (HBHA), and mycobacterial DNA-binding protein 1 (MDP-1) remain elusive in relation to the clinical stage of infection. In the present study, peripheral blood mononuclear cells (PBMCs) collected from different stages of -infected cases and control PBMCs were stimulated with these antigens and ESAT-6/CFP-10. Cytokine profiles of CD4 T cells were evaluated by intracellular cytokine staining using multicolor flow cytometry. Our results demonstrate that Th1 cytokine responses were predominant after TB onset independent of the type of antigen stimulation. On the contrary, non-Th1 cytokine responses were preferentially induced by latency-associated antigens, specifically IL-10 response against Acr in latent infection. From these results, we surmise a shift in the CD4 T cell response from mixed non-Th1 to Th1 dominant type during TB progression.
AbstractList Mycobacterium tuberculosis (M. tuberculosis) produces a diverse range of antigenic proteins in its dormant phase. The cytokine profiles of CD4+ T cell responses, especially subsets other than Th1 type (non-Th1 type), against these latency-associated M. tuberculosis antigens such as α-crystallin (Acr), heparin-binding hemagglutinin (HBHA), and mycobacterial DNA-binding protein 1 (MDP-1) remain elusive in relation to the clinical stage of M. tuberculosis infection. In the present study, peripheral blood mononuclear cells (PBMCs) collected from different stages of M. tuberculosis-infected cases and control PBMCs were stimulated with these antigens and ESAT-6/CFP-10. Cytokine profiles of CD4+ T cells were evaluated by intracellular cytokine staining using multicolor flow cytometry. Our results demonstrate that Th1 cytokine responses were predominant after TB onset independent of the type of antigen stimulation. On the contrary, non-Th1 cytokine responses were preferentially induced by latency-associated M. tuberculosis antigens, specifically IL-10 response against Acr in latent M. tuberculosis infection. From these results, we surmise a shift in the CD4+ T cell response from mixed non-Th1 to Th1 dominant type during TB progression.
( ) produces a diverse range of antigenic proteins in its dormant phase. The cytokine profiles of CD4 T cell responses, especially subsets other than Th1 type (non-Th1 type), against these latency-associated antigens such as α-crystallin (Acr), heparin-binding hemagglutinin (HBHA), and mycobacterial DNA-binding protein 1 (MDP-1) remain elusive in relation to the clinical stage of infection. In the present study, peripheral blood mononuclear cells (PBMCs) collected from different stages of -infected cases and control PBMCs were stimulated with these antigens and ESAT-6/CFP-10. Cytokine profiles of CD4 T cells were evaluated by intracellular cytokine staining using multicolor flow cytometry. Our results demonstrate that Th1 cytokine responses were predominant after TB onset independent of the type of antigen stimulation. On the contrary, non-Th1 cytokine responses were preferentially induced by latency-associated antigens, specifically IL-10 response against Acr in latent infection. From these results, we surmise a shift in the CD4 T cell response from mixed non-Th1 to Th1 dominant type during TB progression.
Mycobacterium tuberculosis (M. tuberculosis) produces a diverse range of antigenic proteins in its dormant phase. The cytokine profiles of CD4+ T cell responses, especially subsets other than Th1 type (non-Th1 type), against these latency-associated M. tuberculosis antigens such as α-crystallin (Acr), heparin-binding hemagglutinin (HBHA), and mycobacterial DNA-binding protein 1 (MDP-1) remain elusive in relation to the clinical stage of M. tuberculosis infection. In the present study, peripheral blood mononuclear cells (PBMCs) collected from different stages of M. tuberculosis-infected cases and control PBMCs were stimulated with these antigens and ESAT-6/CFP-10. Cytokine profiles of CD4+ T cells were evaluated by intracellular cytokine staining using multicolor flow cytometry. Our results demonstrate that Th1 cytokine responses were predominant after TB onset independent of the type of antigen stimulation. On the contrary, non-Th1 cytokine responses were preferentially induced by latency-associated M. tuberculosis antigens, specifically IL-10 response against Acr in latent M. tuberculosis infection. From these results, we surmise a shift in the CD4+ T cell response from mixed non-Th1 to Th1 dominant type during TB progression.Mycobacterium tuberculosis (M. tuberculosis) produces a diverse range of antigenic proteins in its dormant phase. The cytokine profiles of CD4+ T cell responses, especially subsets other than Th1 type (non-Th1 type), against these latency-associated M. tuberculosis antigens such as α-crystallin (Acr), heparin-binding hemagglutinin (HBHA), and mycobacterial DNA-binding protein 1 (MDP-1) remain elusive in relation to the clinical stage of M. tuberculosis infection. In the present study, peripheral blood mononuclear cells (PBMCs) collected from different stages of M. tuberculosis-infected cases and control PBMCs were stimulated with these antigens and ESAT-6/CFP-10. Cytokine profiles of CD4+ T cells were evaluated by intracellular cytokine staining using multicolor flow cytometry. Our results demonstrate that Th1 cytokine responses were predominant after TB onset independent of the type of antigen stimulation. On the contrary, non-Th1 cytokine responses were preferentially induced by latency-associated M. tuberculosis antigens, specifically IL-10 response against Acr in latent M. tuberculosis infection. From these results, we surmise a shift in the CD4+ T cell response from mixed non-Th1 to Th1 dominant type during TB progression.
Mycobacterium tuberculosis ( M. tuberculosis ) produces a diverse range of antigenic proteins in its dormant phase. The cytokine profiles of CD4 + T cell responses, especially subsets other than Th1 type (non-Th1 type), against these latency-associated M. tuberculosis antigens such as α-crystallin (Acr), heparin-binding hemagglutinin (HBHA), and mycobacterial DNA-binding protein 1 (MDP-1) remain elusive in relation to the clinical stage of M. tuberculosis infection. In the present study, peripheral blood mononuclear cells (PBMCs) collected from different stages of M. tuberculosis -infected cases and control PBMCs were stimulated with these antigens and ESAT-6/CFP-10. Cytokine profiles of CD4 + T cells were evaluated by intracellular cytokine staining using multicolor flow cytometry. Our results demonstrate that Th1 cytokine responses were predominant after TB onset independent of the type of antigen stimulation. On the contrary, non-Th1 cytokine responses were preferentially induced by latency-associated M. tuberculosis antigens, specifically IL-10 response against Acr in latent M. tuberculosis infection. From these results, we surmise a shift in the CD4 + T cell response from mixed non-Th1 to Th1 dominant type during TB progression.
Author Osada-Oka, Mayuko
Ozeki, Yuriko
Terahara, Kazutaka
Yamashita, Yoshiro
Oe, Toshiyuki
Edwards, Tansy
Tsunetsugu-Yokota, Yasuko
Yasuda, Ikkoh
Kawakami, Kenji
Matsumoto, Sohkichi
Ariyoshi, Koya
Tanaka, Takeshi
AuthorAffiliation 5 Department of Bacteriology, Niigata University Graduate School of Medicine , Niigata , Japan
7 Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine , London , United Kingdom
2 Department of Respiratory Medicine, National Hospital Organization Higashi-Saga Hospital , Miyaki , Japan
10 Laboratory of Tuberculosis, Institute of Tropical Disease, Universitas Airlangga , Surabaya , Indonesia
1 Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University , Nagasaki , Japan
4 Food Hygiene and Environmental Health, Graduate School of Life and Environmental Science, Kyoto Prefectural University , Kyoto , Japan
6 Department of Immunology, National Institute of Infectious Diseases , Tokyo , Japan
3 Department of Respiratory Medicine, National Hospital Organization Nagasaki-Kawatana Medical Center , Kawatana , Japan
9 Department of Medical Technology, School of Health Science, Tokyo University of Technology , Tokyo , Japan
11 Department of Global Health, Scho
AuthorAffiliation_xml – name: 8 Infection Control and Education Center, Nagasaki University Hospital , Nagasaki , Japan
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Keywords MDP-1
Acr
latent M. tuberculosis infection
HBHA
CD4+ T cells
non-Th1
Language English
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Snippet ( ) produces a diverse range of antigenic proteins in its dormant phase. The cytokine profiles of CD4 T cell responses, especially subsets other than Th1 type...
Mycobacterium tuberculosis (M. tuberculosis) produces a diverse range of antigenic proteins in its dormant phase. The cytokine profiles of CD4+ T cell...
Mycobacterium tuberculosis ( M. tuberculosis ) produces a diverse range of antigenic proteins in its dormant phase. The cytokine profiles of CD4 + T cell...
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CD4+ T cells
HBHA
Immunology
latent M. tuberculosis infection
MDP-1
non-Th1
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Title CD4+ T Responses Other Than Th1 Type Are Preferentially Induced by Latency-Associated Antigens in the State of Latent Mycobacterium tuberculosis Infection
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