Expression of SARS-CoV-2 receptor ACE2 and coincident host response signature varies by asthma inflammatory phenotype

• Published in: Journal of allergy and clinical immunology Vol. 146; no. 2; pp. 315 - 324.e7
• Main Authors: Camiolo, Matthew, Gauthier, Marc, Kaminski, Naftali, Ray, Anuradha, Wenzel, Sally E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2020; American Academy of Allergy, Asthma & Immunology
• Subjects: ACE2; Adolescent; Adult; Angiotensin-Converting Enzyme 2; asthma; Asthma - classification; Asthma - epidemiology; Asthma - genetics; Asthma - immunology; Betacoronavirus - genetics; Betacoronavirus - immunology; Biomarkers - metabolism; Bronchi - immunology; Bronchi - pathology; Bronchoalveolar Lavage Fluid - cytology; Bronchoalveolar Lavage Fluid - immunology; Cohort Studies; coronavirus; Coronavirus Infections - epidemiology; Coronavirus Infections - virology; COVID-19; Eosinophils - immunology; Eosinophils - pathology; Female; Gene Expression Profiling; Humans; Interferon Type I - genetics; Interferon Type I - immunology; Interferon-gamma - genetics; Interferon-gamma - immunology; interferons; Male; Middle Aged; Pandemics; Peptidyl-Dipeptidase A - genetics; Peptidyl-Dipeptidase A - immunology; Pneumonia, Viral - epidemiology; Pneumonia, Viral - virology; Protein Interaction Mapping; Receptors, Virus - genetics; Receptors, Virus - immunology; Risk Factors; SARS-CoV-2; Severity of Illness Index; T-Lymphocytes - classification; T-Lymphocytes - immunology; T-Lymphocytes - pathology; Transcriptome; Type-2 low; United States - epidemiology; viral response; United States; PC4; BEC; coronavirus; asthma; SARP; viral response; BAL; COVID-19; IMSA; ACE2; SARS-CoV-2; STAT; interferons; Type-2 low; T1; T2; PC1
• ISSN: 0091-6749; 1097-6825; 1097-6825
• DOI: 10.1016/j.jaci.2020.05.051

More than 300 million people carry a diagnosis of asthma, with data to suggest that they are at a higher risk for infection or adverse outcomes from severe acute respiratory syndrome coronavirus 2. Asthma is remarkably heterogeneous, and it is currently unclear how patient-intrinsic factors may rela...