The Population Reference Sample, POPRES: A Resource for Population, Disease, and Pharmacological Genetics Research

• Published in: American journal of human genetics Vol. 83; no. 3; pp. 347 - 358
• Main Authors: Nelson, Matthew R., Bryc, Katarzyna, King, Karen S., Indap, Amit, Boyko, Adam R., Novembre, John, Briley, Linda P., Maruyama, Yuka, Waterworth, Dawn M., Waeber, Gérard, Vollenweider, Peter, Oksenberg, Jorge R., Hauser, Stephen L., Stirnadel, Heide A., Kooner, Jaspal S., Chambers, John C., Jones, Brendan, Mooser, Vincent, Bustamante, Carlos D., Roses, Allen D., Burns, Daniel K., Ehm, Margaret G., Lai, Eric H.
• Format: Journal Article
• Language: English
• Published: Chicago, IL Elsevier Inc 01.09.2008; University of Chicago Press; Cell Press; Elsevier
• Subjects: Biological and medical sciences; Biological variation; Case-Control Studies; Databases, Genetic; Deoxyribonucleic acid; Dideoxynucleosides - adverse effects; DNA; Drug Hypersensitivity - ethnology; Drug Hypersensitivity - etiology; Drug Hypersensitivity - genetics; Female; Fundamental and applied biological sciences. Psychology; General aspects. Genetic counseling; Genetics of eukaryotes. Biological and molecular evolution; Genetics, Population; Genome, Human; Genotype; Genotype & phenotype; Human; Human Genome Project; Humans; Male; Medical genetics; Medical sciences; Molecular and cellular biology; Pharmacogenetics; Polymorphism; Polymorphism, Single Nucleotide; Population genetics; Population genetics, reproduction patterns; Population Groups - genetics; White People - genetics; Human; Disease; Sample; Resource; Population; Research; Population genetics

Technological and scientific advances, stemming in large part from the Human Genome and HapMap projects, have made large-scale, genome-wide investigations feasible and cost effective. These advances have the potential to dramatically impact drug discovery and development by identifying genetic facto...