Initiation, Continuation, Switching, and Withdrawal of Heart Failure Medical Therapies During Hospitalization

• Published in: JACC. Heart failure Vol. 7; no. 1; pp. 1 - 12
• Main Authors: Bhagat, Aditi A., Greene, Stephen J., Vaduganathan, Muthiah, Fonarow, Gregg C., Butler, Javed
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2019
• Subjects: Adrenergic beta-Antagonists - therapeutic use; Aminobutyrates - therapeutic use; Angiotensin Receptor Antagonists - therapeutic use; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Biphenyl Compounds; Clinical Decision-Making; Deprescriptions; Drug Combinations; Drug Substitution; heart failure; Heart Failure - drug therapy; Heart Failure - physiopathology; Hospitalization; Humans; medical decision making; Medication Adherence; medication discontinuation; Mineralocorticoid Receptor Antagonists - therapeutic use; Practice Guidelines as Topic; Stroke Volume; Tetrazoles - therapeutic use; Valsartan; heart failure; ARB; ARNI; GDMT; ACEI; medical decision making; medication adherence; MI; HFrEF; MRA; HF; medication discontinuation

Patients with worsening heart failure with reduced ejection fraction (HFrEF) spend a large proportion of time in the hospital and other health care facilities. The benefits of guideline-directed medical therapy (GDMT) in the outpatient setting have been shown in large randomized controlled trials. H...