Erythrocytes From Patients With Type 2 Diabetes Induce Endothelial Dysfunction Via Arginase I

• Published in: Journal of the American College of Cardiology Vol. 72; no. 7; pp. 769 - 780
• Main Authors: Zhou, Zhichao, Mahdi, Ali, Tratsiakovich, Yahor, Zahorán, Szabolcs, Kövamees, Oskar, Nordin, Filip, Uribe Gonzalez, Arturo Eduardo, Alvarsson, Michael, Östenson, Claes-Göran, Andersson, Daniel C, Hedin, Ulf, Hermesz, Edit, Lundberg, Jon O, Yang, Jiangning, Pernow, John
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.08.2018; Elsevier Limited
• Subjects: Aged; Animals; Arginase; Arginase - antagonists & inhibitors; Arginase - biosynthesis; Arteries; Bioavailability; Cardiology; Cardiovascular; Cardiovascular disease; Cholesterol; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - enzymology; Dose-Response Relationship, Drug; endothelial dysfunction; Endothelium; Endothelium, Vascular - drug effects; Endothelium, Vascular - enzymology; Enzyme Inhibitors - pharmacology; Erythrocytes; Erythrocytes - drug effects; Erythrocytes - enzymology; Female; Humans; Laboratory animals; Low density lipoprotein; Male; Middle Aged; Nitric oxide; Organ Culture Techniques; Patients; Rats; Reactive oxygen species; Reactive Oxygen Species - metabolism; red blood cell; Smooth muscle; Thoracic surgery; Triglycerides; type 2 diabetes; Variance analysis; vascular complication; Vasodilation - drug effects; Vasodilation - physiology; Vasodilator Agents - pharmacology; NADPH; NO; T2DM; eNOS; vascular complication; GK; ABH; T2DM RBC; H2O2; Healthy RBC; endothelial dysfunction; arginase; red blood cell; EIR; NAC; EDR; RBC; type 2 diabetes; NOS; NOX; reactive oxygen species; ROS; KH; EC; red blood cell from patients with type 2 diabetes mellitus; Goto-Kakizaki; 2(S)-amino-6-boronohexanoic acid; Krebs-Henseleit; type 2 diabetes mellitus; endothelial nitric oxide synthase; nitric oxide synthase; endothelium-dependent relaxation; red blood cell from healthy subjects; nitric oxide; endothelial cell; hydrogen peroxide; nicotinamide adenine dinucleotide phosphate; H 2O 2; N -acetyl-cysteine; endothelium-independent relaxation; nicotinamide adenine dinucleotide phosphate oxidase

Cardiovascular complications are major clinical problems in type 2 diabetes mellitus (T2DM). The authors previously demonstrated a crucial role of red blood cells (RBCs) in control of cardiac function through arginase-dependent regulation of nitric oxide export from RBCs. There is alteration of RBC...