Erythrocytes From Patients With Type 2 Diabetes Induce Endothelial Dysfunction Via Arginase I - Zhou, Zhichao; Mahdi, Ali; Tratsiakovich, Yahor; Zahorán, Szabolcs; Kövamees, Oskar; Nordin, Filip; Uribe Gonzalez, Arturo Eduardo; Alvarsson, Michael; Östenson, Claes-Göran; Andersson, Daniel C; Hedin, Ulf; Hermesz, Edit; et al. (Journal of the American College of Cardiology, 2018)
Keywords: Aged; Animals; Arginase; Arginase - antagonists & inhibitors; Arginase - biosynthesis; Arteries; Bioavailability; Cardiology; Cardiovascular; Cardiovascular disease; Cholesterol; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - enzymology; Dose-Response Relationship, Drug; endothelial dysfunction; Endothelium; Endothelium, Vascular - drug effects; Endothelium, Vascular - enzymology; Enzyme Inhibitors - pharmacology; Erythrocytes; Erythrocytes - drug effects; Erythrocytes - enzymology; Female; Humans; Laboratory animals; Low density lipoprotein; Male; Middle Aged; Nitric oxide; Organ Culture Techniques; Patients; Rats; Reactive oxygen species; Reactive Oxygen Species - metabolism; red blood cell; Smooth muscle; Thoracic surgery; Triglycerides; type 2 diabetes; Variance analysis; vascular complication; Vasodilation - drug effects; Vasodilation - physiology; Vasodilator Agents - pharmacology; NADPH; NO; T2DM; eNOS; vascular complication; GK; ABH; T2DM RBC; H2O2; Healthy RBC; endothelial dysfunction; arginase; red blood cell; EIR; NAC; EDR; RBC; type 2 diabetes; NOS; NOX; reactive oxygen species; ROS; KH; EC; red blood cell from patients with type 2 diabetes mellitus; Goto-Kakizaki; 2(S)-amino-6-boronohexanoic acid; Krebs-Henseleit; type 2 diabetes mellitus; endothelial nitric oxide synthase; nitric oxide synthase; endothelium-dependent relaxation; red blood cell from healthy subjects; nitric oxide; endothelial cell; hydrogen peroxide; nicotinamide adenine dinucleotide phosphate; H 2O 2; N -acetyl-cysteine; endothelium-independent relaxation; nicotinamide adenine dinucleotide phosphate oxidase