A metabolically engineered bacterium controls autoimmunity and inflammation by remodeling the pro-inflammatory microenvironment

• Published in: Gut Microbes Vol. 14; no. 1; p. 2143222
• Main Authors: Das, Jugal Kishore, Guo, Fengguang, Hunt, Carrie, Steinmeyer, Shelby, Plocica, Julia A, Kobayashi, Koichi S., Ding, Yufang, Jayaraman, Arul, Ficht, Thomas A, Alaniz, Robert C., de Figueiredo, Paul, Song, Jianxun
• Format: Journal Article
• Language: English
• Published: United States Informa UK Limited 20.11.2022; Taylor & Francis; Taylor & Francis Group
• Subjects: Autoimmunity; Bacteria; Bacteria - metabolism; Brief Report; Cytokines; Cytokines - metabolism; Diseases of the digestive system. Gastroenterology; Gastrointestinal Microbiome; Humans; immunometabolism; Inflammation; Microbe; RC799-869; regulatory T cells; T-Lymphocytes, Regulatory; regulatory T cells; Microbe; autoimmunity; immunometabolism; inflammation

Immunotherapy has led to impressive advances in the treatment of autoimmune and pro-inflammatory disorders; yet, its clinical outcomes remain limited by a variety of factors including the pro-inflammatory microenvironment (IME). Discovering effective immunomodulatory agents, and the mechanisms by wh...