The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions

• Published in: Journal of allergy and clinical immunology Vol. 149; no. 2; pp. 488 - 516.e9
• Main Authors: Ivanova, Anastasia, Israel, Elliot, Denlinger, Loren C., Phipatanakul, Wanda, Bacharier, Leonard B., Castro, Mario, Gaston, Benjamin, Khatri, Sumita, Kirwan, John P., Marquis, M. Alison, Moy, James N., Ortega, Victor E., Peters, Michael C., Ross, Kristie, Wenzel, Sally E., Zeki, Amir A., Noel, Patricia, Billheimer, Dean, Daines, Cori, Deaton, Isaac, Field, Paige, Hastie, Annette T., Hmieleski, Bob, Peters, Stephen P., Pippins, Anna, Schunk, Ronald, Banzon, Tina M., Bartnikas, Lisa M., Crestani, Elena, Day-Lewis, Megan, Esty, Brittany, Fandozzi, Eva, Fernandez, Jesse, Imanirad, Donya S., Louisias, Margee, O’Neill, Allison, Sheehan, William, Socolovsky, Carmela, Treffeisen, Else, Trippa, Lorenzo, Garcia, Vanessa, Jackson, Carly, Kalhan, Ravi, Li, Grace, Rosenberg, Sharon R., Sheng, Jianrong, Bitzan, Jennifer, Cruse, Margaret Hope, Estrom, Jean, Grant, Nicole, Manka, Laurie A., Pruitt, Diana M., Thomas, Kisori, Valente, Karissa, Brownell, Joshua, DeLisa, Julie, Fichtinger, Paul S., Goswamy, Vinay, Grogan, Jenelle, Hasse, Wendy, Mathur, Sameer K., Norwick, Lourdes M., Nyenhuis, Sharmilee M., Pappalardo, Andrea A., Rosenberg, Daniel L., Wollet, Lori, France, Lisa, Gluvna, Adam, Hyser, Elise, Krupp, Nadia L., Matuska, Brittany, Roesch, Erica A., Sanders, Don B., Teague, W. Gerald, Camiolo, Matt, Demas, Jessa, Elvin, Courtney, Lane, Lisa, Zhang, Michael, Brickner, Howard, Celso, Janelle, Du, Ashley, Nazir, Yusife, Ryu, Julie, Haczku, Angela, Harper, Richart W., Heromin, Raymond, Kuhn, Brooks T., McCourt, Paula, Singapuri, Amisha, Boomer, Jonathan S., Curtis, Vanessa, Thompson, Brynne, Britt, Ashley, Bryan, Hope, Jiang, Yue, Kosorok, Michael R., Meekins, Kelsey, Mollenhauer, Jeanette K., Ritz, Cheyanne
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2022
• Subjects: adaptive clinical trial design; Adaptive Clinical Trials as Topic; Advisory Committees; Asthma - diagnosis; Asthma - drug therapy; asthma exacerbation; biomarker; Biomarkers; Clinical Protocols; Clinical Trials, Phase II as Topic; Humans; non–type 2 asthma; patient advisory committee; Precision Medicine; Research Design; Severe asthma; Severity of Illness Index; Tomography, X-Ray Computed; type 2 asthma; CRP; Feno; NO; FDA; PPC; DSMB; RV; non–type 2 asthma; RTI; DMCC; GSNOR; TLC; patient advisory committee; GSNO; RFA; COVID-19; SC; SNP; MC; asthma exacerbation; Severe asthma; EC; adaptive clinical trial design; CC; ppb; PrecISE; AE; CompEx; Treg; SARP; ACQ-6; biomarker; type 2 asthma; STAT; PAC; TCA; NHLBI; JAK; SAE; ICS; IRB; precision medicine; PI; MCT
• ISSN: 0091-6749; 1097-6825; 1097-6825
• DOI: 10.1016/j.jaci.2021.10.035

Asthma is a heterogeneous disease, with multiple underlying inflammatory pathways and structural airway abnormalities that impact disease persistence and severity. Recent progress has been made in developing targeted asthma therapeutics, especially for subjects with eosinophilic asthma. However, the...