Folic acid metabolism in human subjects revisited: potential implications for proposed mandatory folic acid fortification in the UK

• Published in: British journal of nutrition Vol. 98; no. 4; pp. 667 - 675
• Main Authors: Wright, Anthony J. A., Dainty, Jack R., Finglas, Paul M.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.10.2007
• Subjects: Absorption; Acids; adverse effects; Biotransformation; dietary recommendations; Dietary Supplements; Dihydrofolate reductase; drug effects; enzyme activity; Female; Folate; Folic acid; Folic Acid - adverse effects; Folic Acid - metabolism; Folic Acid - pharmacokinetics; food fortification; Food, Fortified; Fortification; fortified foods; Great Britain; Human subjects; Humans; Intestinal Absorption; Intestinal Absorption - drug effects; Intestine, Small; Intestine, Small - metabolism; Isotope Labeling; Isotope studies; literature reviews; Liver; Liver - drug effects; Liver - metabolism; Male; Metabolism; Nitrogen Isotopes; Nitrogen Isotopes - metabolism; nutrition physiology; pharmacokinetics; Physiology; Plasma; Pteroylmonoglutamic acid; Small intestine; stable isotopes; Supplementation; United Kingdom; Veins & arteries; Vitamin B; vitamin metabolism; United Kingdom; Great Britain; Human subjects; Pteroylmonoglutamic acid; Absorption; Supplementation; Metabolism; Fortification; Folic acid; Folate

Following an introduction of the importance of folates and the rationale for seeking to estimate fractional folate absorption from foods (especially for countries not having a mandatory folic acid fortification policy), scientific papers covering the mechanisms of folate absorption and initial biotr...