Concomitant Enhancement of HIV-1 Replication Potential and Neutralization-Resistance in Concert With Three Adaptive Mutations in Env V1/C2/C4 Domains

• Published in: Frontiers in microbiology Vol. 10; p. 2
• Main Authors: Doi, Naoya, Yokoyama, Masaru, Koma, Takaaki, Kotani, Osamu, Sato, Hironori, Adachi, Akio, Nomaguchi, Masako
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 17.01.2019
• Subjects: adaptive mutation; CD4; Env; HIV-1; Microbiology; neutralization sensitivity; replication potential; HIV-1; CD4; replication potential; neutralization sensitivity; adaptive mutation; Env structure; Env

HIV-1 Env protein functions in the entry process and is the target of neutralizing antibodies. Its intrinsically high mutation rate is certainly one of driving forces for persistence/survival in hosts. For optimal replication in various environments, HIV-1 Env must continue to adapt and evolve throu...