Longitudinal resting-state EEG in amyloid-positive patients along the Alzheimer’s disease continuum: considerations for clinical trials

• Published in: Alzheimer's research & therapy Vol. 15; no. 1; pp. 1 - 19
• Main Authors: Scheijbeler, Elliz P., de Haan, Willem, Stam, Cornelis J., Twisk, Jos W. R., Gouw, Alida A.
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 19.10.2023; BioMed Central; BMC
• Subjects: Advertising executives; Alzheimer's disease; Atrophy; Biomarkers; Brain research; Clinical trial design; Clinical trials; Cognitive ability; Dementia; Diagnosis; Electroencephalography; FDA approval; Functional endpoint; Longitudinal; Longitudinal studies; Magnetic resonance imaging; Medical research; Medicine, Experimental; Methods; Neurodegeneration; Neurophysiology; Resting state; Netherlands

Background To enable successful inclusion of electroencephalography (EEG) outcome measures in Alzheimer's disease (AD) clinical trials, we retrospectively mapped the progression of resting-state EEG measures over time in amyloid-positive patients with mild cognitive impairment (MCI) or dementia...