Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

• Published in: Nature structural & molecular biology Vol. 22; no. 6; pp. 476 - 484
• Main Authors: Xu, Haiyan, Gustafson, Chelsea L, Sammons, Patrick J, Khan, Sanjoy K, Parsley, Nicole C, Ramanathan, Chidambaram, Lee, Hsiau-Wei, Liu, Andrew C, Partch, Carrie L
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.06.2015; Nature Publishing Group
• Subjects: 101/6; 38/77; 631/45/535/878/1263; 631/45/612/822; 631/57/2269; 631/80/105; 82/111; 82/29; 96/106; 96/109; Animals; ARNTL Transcription Factors - metabolism; Biochemistry; Biological Microscopy; Cells, Cultured; Circadian Clocks; Circadian rhythm; Circadian rhythms; Cryptochromes - metabolism; Fibroblasts - physiology; Genetic aspects; Humans; Life Sciences; Mammals; Membrane Biology; Mice; Mice, Knockout; Molecular biology; Mutation; Physiological aspects; Protein Structure; Structure; Transcription factors; United States

The mammalian circadian cycle is determined by sequential activation of clock target-gene expression by CLOCK–BMAL and subsequent repression by CRY. Biochemical and NMR data now show that Cry1 competes with coactivators for binding to the BMAL1 transcriptional-activation domain to regulate circadian...