Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial

• Published in: The American journal of geriatric psychiatry Vol. 26; no. 3; p. 266
• Main Authors: Small, Gary W, Siddarth, Prabha, Li, Zhaoping, Miller, Karen J, Ercoli, Linda, Emerson, Natacha D, Martinez, Jacqueline, Wong, Koon-Pong, Liu, Jie, Merrill, David A, Chen, Stephen T, Henning, Susanne M, Satyamurthy, Nagichettiar, Huang, Sung-Cheng, Heber, David, Barrio, Jorge R
• Format: Journal Article
• Language: English
• Published: England 01.03.2018
• Subjects: Aged; Aged, 80 and over; Aging - drug effects; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Attention - drug effects; Brain - diagnostic imaging; Brain - drug effects; Curcumin - administration & dosage; Curcumin - pharmacology; Double-Blind Method; Female; Humans; Male; Memory - drug effects; Middle Aged; Placebos; Plaque, Amyloid - drug therapy; Positron-Emission Tomography; tau Proteins - drug effects; Treatment Outcome; normal aging; memory; cognition; positron emission tomography; Bioavailable curcumin

Because curcumin's anti-inflammatory properties may protect the brain from neurodegeneration, we studied its effect on memory in non-demented adults and explored its impact on brain amyloid and tau accumulation using 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitri...