Wall shear stress is decreased in the pulmonary arteries of patients with pulmonary arterial hypertension: An image-based, computational fluid dynamics study

• Published in: Pulmonary circulation Vol. 2; no. 4; pp. 470 - 476
• Main Authors: Tang, Beverly T., Pickard, Sarah S., Chan, Frandics P., Tsao, Philip S., Taylor, Charles A., Feinstein, Jeffrey A.
• Format: Journal Article
• Language: English
• Published: London, England University of Chicago Press 01.10.2012; SAGE Publications; Sage Publications Ltd. (UK); John Wiley & Sons, Inc; Medknow Publications & Media Pvt Ltd
• Subjects: Arteries; biomedical engineering; Blood pressure; Blood vessels; Cardiovascular system; computer simulation; Development and progression; Diagnosis; Disease progression; endothelium‐derived factors; Flow velocity; Fluid dynamics; Gene expression; Magnetic resonance angiography; Magnetic resonance imaging; Physiological aspects; Prognosis; Pulmonary arteries; Pulmonary artery; Pulmonary hypertension; Research Article; Shear stress; Stress (Psychology); Vascular diseases; Veins & arteries; United States; endothelium-derived factors; computer simulation; biomedical engineering

Previous clinical studies in pulmonary arterial hypertension (PAH) have concentrated predominantly on distal pulmonary vascular resistance, its contribution to the disease process, and response to therapy. However, it is well known that biomechanical factors such as shear stress have an impact on en...