Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles

• Published in: Circulation research Vol. 127; no. 9; pp. 1198 - 1210
• Main Authors: He, Yi, Ronsein, Graziella E., Tang, Chongren, Jarvik, Gail P., Davidson, W. Sean, Kothari, Vishal, Song, Hyun D., Segrest, Jere P., Bornfeldt, Karin E., Heinecke, Jay W.
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 09.10.2020
• Subjects: prevalence; diabetes mellitus; tandem mass spectrometry; proteomics; serpins

RATIONALE:HDL (high-density lipoprotein) may be cardioprotective because it accepts cholesterol from macrophages via the cholesterol transport proteins ABCA1 (ATP-binding cassette transporter A1) and ABCG1 (ATP-binding cassette transporter G1). The ABCA1-specific cellular cholesterol efflux capacity...