Lack of effect of nitrendipine on the pharmacokinetics and pharmacodynamics of midazolam during steady state

• Published in: British journal of clinical pharmacology Vol. 25; no. 2; pp. 243 - 250
• Main Authors: Handel, J, Ziegler, G, Gemeinhardt, A, Stuber, H, Fischer, C, Klotz, U
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.1988; Blackwell Science
• Subjects: Adult; Antianginal agents. Coronary vasodilator agents; Biological and medical sciences; Cardiovascular system; Drug Interactions; Electroencephalography; Female; Humans; Male; Medical sciences; Midazolam - pharmacokinetics; Midazolam - pharmacology; Nitrendipine - pharmacokinetics; Nitrendipine - pharmacology; Pharmacology. Drug treatments; Psychomotor Performance - drug effects; Human; Calcium; Activity concentration relation; Calcium antagonist; Benzodiazepine derivatives; Ionic channel; Drug interaction; Metabolism; Pharmacokinetics; Activity metabolism relation

1. The possible interaction (as indicated by rat experiments) between calcium channel blocking agents and benzodiazepines has been evaluated in nine healthy subjects. 2. Subsequently to an intravenous loading dose (0.07 mg kg‐1) midazolam was infused for 6 h (0.035 mg kg‐1 h‐1) and steady state plas...