Blimp‐1 homolog Hobit identifies effector‐type lymphocytes in humans

• Published in: European journal of immunology Vol. 45; no. 10; pp. 2945 - 2958
• Main Authors: Vieira Braga, Felipe A., Hertoghs, Kirsten M. L., Kragten, Natasja A. M., Doody, Gina M., Barnes, Nicholas A., Remmerswaal, Ester B. M., Hsiao, Cheng‐Chih, Moerland, Perry D., Wouters, Diana, Derks, Ingrid A. M., Stijn, Amber, Demkes, Marc, Hamann, Jörg, Eldering, Eric, Nolte, Martijn A., Tooze, Reuben M., ten Berge, Ineke J. M., Gisbergen, Klaas P. J. M., Lier, René A. W.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.10.2015
• Subjects: Animals; CD8 T cells; CD8-Positive T-Lymphocytes - immunology; Cell Line; Cytomegalovirus; Cytomegalovirus - immunology; Human cytomegalovirus; Humans; Influenza A virus - immunology; Interferon-gamma - genetics; Interferon-gamma - immunology; Lymphocytes; Mice; Natural Killer T-Cells - immunology; NK cells; Positive Regulatory Domain I-Binding Factor 1; Repressor Proteins - genetics; Repressor Proteins - immunology; T cell receptors; Transcription factors; Transcription Factors - genetics; Transcription Factors - immunology; NK cells; Transcription factors; CD8 T cells

Human cytomegalovirus (CMV) induces the formation of effector CD8+ T cells that are maintained for decades during the latent stage of infection. Effector CD8+ T cells appear quiescent, but maintain constitutive cytolytic capacity and can immediately produce inflammatory cytokines such as IFN‐γ after...