A phase response curve to single bright light pulses in human subjects

• Published in: The Journal of physiology Vol. 549; no. 3; pp. 945 - 952
• Main Authors: Khalsa, Sat Bir S., Jewett, Megan E., Cajochen, Christian, Czeisler, Charles A.
• Format: Journal Article
• Language: English
• Published: Legacy CDMS The Physiological Society 15.06.2003; Blackwell Publishing Ltd; Blackwell Science Inc
• Subjects: Adult; Body Temperature; Circadian Rhythm - radiation effects; Female; Humans; Life Sciences (General); Male; Melatonin - blood; Melatonin - urine; Original; Photic Stimulation; Photoperiod; Support, U.s. Gov't, Non-P.h.s; Human; Support, Non-U.s. Gov't; Clinical Trial; Support, U.s. Gov't, P.h.s; Non-Nasa Center; Male; Circadian Rhythm/radiation Effects; Photoperiod; Randomized Controlled Trial; Body Temperature; Melatonin/blood/urine; Nasa Program Biomedical Research And Countermeasures; Nasa Discipline Regulatory Physiology; Adult; Female; Photic Stimulation; NASA Program Biomedical Research and Countermeasures; NASA Discipline Regulatory Physiology; Non-NASA Center

The circadian pacemaker is differentially sensitive to the resetting effects of retinal light exposure, depending upon the circadian phase at which the light exposure occurs. Previously reported human phase response curves (PRCs) to single bright light exposures have employed small sample sizes, and...