High-Density Lipoprotein Reduces the Human Monocyte Inflammatory Response

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 28; no. 11; pp. 2071 - 2077
• Main Authors: Murphy, Andrew J, Woollard, Kevin J, Hoang, Anh, Mukhamedova, Nigora, Stirzaker, Roslynn A, McCormick, Sally P.A, Remaley, Alan T, Sviridov, Dmitri, Chin-Dusting, Jaye
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.11.2008; Hagerstown, MD Lippincott
• Subjects: Actins - metabolism; Apolipoprotein A-I - metabolism; Atherosclerosis (general aspects, experimental research); Atherosclerosis - metabolism; Atherosclerosis - pathology; Atherosclerosis - prevention & control; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters - metabolism; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; CD11b Antigen - metabolism; Cell Adhesion; Cell Shape; Cells, Cultured; Cholesterol - deficiency; Cholesterol - metabolism; Cyclodextrins - pharmacology; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Endothelial Cells - metabolism; General and cellular metabolism. Vitamins; Humans; Inflammation - metabolism; Inflammation - pathology; Inflammation - prevention & control; Lipoproteins, HDL - metabolism; Medical sciences; Membrane Microdomains - metabolism; Monocytes - drug effects; Monocytes - metabolism; Monocytes - pathology; Pharmacology. Drug treatments; Platelet Adhesiveness; Scavenger Receptors, Class B; Stress, Mechanical; Tangier Disease - metabolism; Tetradecanoylphorbol Acetate - pharmacology; Time Factors; Vascular disease; Human; ABCA1; Tangier; Apolipoprotein A; Monocyte; Atherosclerosis; Cardiovascular disease; Lipoprotein; apolipoprotein A-I; CD11b

OBJECTIVE—Whereas the anti–inflammatory effects of high-density lipoprotein (HDL) on endothelial cells are well described, such effects on monocytes are less studied. METHODS AND RESULTS—Human monocytes were isolated from whole blood followed by assessment of CD11b activation/expression and cell adh...