急性切口痛大鼠血浆及上消化道胃动素表达的变化
目的：观察急性切口痛大鼠血浆、胃体及十二指肠胃动素（MTL）水平的变化。方法 SPF级健康雄性SD大鼠156只，6～8周龄，体质量180～220 g，采用随机数字表法将其分为2组（n=78）：对照组（C组）和切口痛组（P组）。P组行右足跖肌切口。2组先随机各取6只大鼠，于术前24 h（T0）、术后1 h（T1）、6 h（T2）、24 h（T3）、48 h（T4）、72 h（T5）测定机械缩足阈值（PWMT）与热缩足反射潜伏期（PWTL）。并于上述每个时点，2组分别取12只大鼠，断头处死，提取血浆、胃体及十二指肠组织，采用ELISA法测定MTL水平。结果与C组比较，P组T1～T4时PWMT降低，...
Saved in:
| Published in | 天津医药 Vol. 43; no. 3; pp. 263 - 266 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
天津医科大学三中心临床学院 邮编300170%天津市第三中心医院重症医学科、天津市人工细胞重点实验室%天津医科大学附属肿瘤医院麻醉科
2015
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-9896 |
| DOI | 10.3969/j.issn.0253-9896.2015.03.011 |
Cover
| Abstract | 目的：观察急性切口痛大鼠血浆、胃体及十二指肠胃动素（MTL）水平的变化。方法 SPF级健康雄性SD大鼠156只，6～8周龄，体质量180～220 g，采用随机数字表法将其分为2组（n=78）：对照组（C组）和切口痛组（P组）。P组行右足跖肌切口。2组先随机各取6只大鼠，于术前24 h（T0）、术后1 h（T1）、6 h（T2）、24 h（T3）、48 h（T4）、72 h（T5）测定机械缩足阈值（PWMT）与热缩足反射潜伏期（PWTL）。并于上述每个时点，2组分别取12只大鼠，断头处死，提取血浆、胃体及十二指肠组织，采用ELISA法测定MTL水平。结果与C组比较，P组T1～T4时PWMT降低，PWTL缩短，血浆、胃体MTL水平降低，而十二指肠MTL水平升高（P＜0.05），T0、T5时差异无统计学意义；P组血浆MTL水平与PWMT、PWTL呈正相关（r分别为0.952、0.879，P＜0.01），P组胃体MTL水平与PWMT、PWTL呈正相关性（r分别为0.970、0.931，P＜0.01）；十二指肠MTL水平与PWMT、PWTL呈负相关性（r分别为-0.991、-0.975，P＜0.01）。结论急性切口痛可使大鼠血浆、胃体MTL水平降低，而使十二指肠MTL水平升高。 |
|---|---|
| AbstractList | 目的：观察急性切口痛大鼠血浆、胃体及十二指肠胃动素（MTL）水平的变化。方法 SPF级健康雄性SD大鼠156只，6～8周龄，体质量180～220 g，采用随机数字表法将其分为2组（n=78）：对照组（C组）和切口痛组（P组）。P组行右足跖肌切口。2组先随机各取6只大鼠，于术前24 h（T0）、术后1 h（T1）、6 h（T2）、24 h（T3）、48 h（T4）、72 h（T5）测定机械缩足阈值（PWMT）与热缩足反射潜伏期（PWTL）。并于上述每个时点，2组分别取12只大鼠，断头处死，提取血浆、胃体及十二指肠组织，采用ELISA法测定MTL水平。结果与C组比较，P组T1～T4时PWMT降低，PWTL缩短，血浆、胃体MTL水平降低，而十二指肠MTL水平升高（P＜0.05），T0、T5时差异无统计学意义；P组血浆MTL水平与PWMT、PWTL呈正相关（r分别为0.952、0.879，P＜0.01），P组胃体MTL水平与PWMT、PWTL呈正相关性（r分别为0.970、0.931，P＜0.01）；十二指肠MTL水平与PWMT、PWTL呈负相关性（r分别为-0.991、-0.975，P＜0.01）。结论急性切口痛可使大鼠血浆、胃体MTL水平降低，而使十二指肠MTL水平升高。 R614; 目的：观察急性切口痛大鼠血浆、胃体及十二指肠胃动素（MTL）水平的变化。方法 SPF级健康雄性SD大鼠156只，6～8周龄，体质量180～220 g，采用随机数字表法将其分为2组（n=78）：对照组（C组）和切口痛组（P组）。P组行右足跖肌切口。2组先随机各取6只大鼠，于术前24 h（T0）、术后1 h（T1）、6 h（T2）、24 h（T3）、48 h（T4）、72 h（T5）测定机械缩足阈值（PWMT）与热缩足反射潜伏期（PWTL）。并于上述每个时点，2组分别取12只大鼠，断头处死，提取血浆、胃体及十二指肠组织，采用ELISA法测定MTL水平。结果与C组比较，P组T1~T4时PWMT降低，PWTL缩短，血浆、胃体MTL水平降低，而十二指肠MTL水平升高（P＜0.05），T0、T5时差异无统计学意义；P组血浆MTL水平与PWMT、PWTL呈正相关（r分别为0.952、0.879，P＜0.01），P组胃体MTL水平与PWMT、PWTL呈正相关性（r分别为0.970、0.931，P＜0.01）；十二指肠MTL水平与PWMT、PWTL呈负相关性（r分别为-0.991、-0.975，P＜0.01）。结论急性切口痛可使大鼠血浆、胃体MTL水平降低，而使十二指肠MTL水平升高。 |
| Abstract_FL | Objective To observe changes of motilin(MTL) levels in gastric body, duodenum and plasma in rat model of acute incisional pain.Methods A total of 156 healthy male adult SD rats,weighing 180-220 g,were randomized into two groups:control group (group C,n=78) and incisional pain group (group P,n=78),Rats in P group received incision on the right plantaris. Values of paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) at dif?ferent time points of 24 hours before operation (T0) and 1 hour (T1),6 hours (T2),24 hours(T3),48 hours (T4) and 72 hours (T5) after operation were measured in six rats chosen randomly from each group. Twelve rats were chosen from each group at T 0-5, and sacrificed. The MTL levels in plasma, the mucosal tissues of gastric body and duodenum were detected by ELISA. Re?sults Compared with group C, PWMT and PWTL were significantly decreased at T1-4 in group P. The MTL levels were sig?nificantly decreased in plasma and gastric body (P<0.05).The MTL level was significantly increased at T1-4 in duodenum (P<0.05),and no significant changes were found at T0 and T5 in P group(P>0.05). The plasma MTL levels were positively correlated with PWMT and PWTL (r=0.952,r=0.879,respectively,P<0.01) in P group. The MTL levels in gastric body were positively correlated with PWMT and PWTL(r=0.970,r=0.931,respectively,P<0.01) in P group. The MTL levels were neg?atively correlated with PWMT and PWTL(r=-0.991,r=-0.975,respectively,P<0.01) in duodenum in P group. Conclu?sion The MTL levels in plasma and gastric body are decreased in rat model of acute incisional pain, and increased in duo?denum. |
| Author | 赵军 徐磊 张瑜 冯全胜 |
| AuthorAffiliation | 天津医科大学三中心临床学院,300170 天津市第三中心医院重症医学科、天津市人工细胞重点实验室 天津医科大学附属肿瘤医院麻醉科 |
| AuthorAffiliation_xml | – name: 天津医科大学三中心临床学院 邮编300170%天津市第三中心医院重症医学科、天津市人工细胞重点实验室%天津医科大学附属肿瘤医院麻醉科 |
| Author_FL | ZHAO Jun ZHANG Yu FENG Quansheng XU Lei |
| Author_FL_xml | – sequence: 1 fullname: ZHAO Jun – sequence: 2 fullname: XU Lei – sequence: 3 fullname: ZHANG Yu – sequence: 4 fullname: FENG Quansheng |
| Author_xml | – sequence: 1 fullname: 赵军 徐磊 张瑜 冯全胜 |
| BookMark | eNo9j89LAkEcxedgkJn_RNRxt-_M7MzsHEv6BUIX7zK7OrZSY7lFeDOMEgk8BBV1KSr0D6joEP41zar_RRtGpwfvfXiPt4AypmGqCC1jcKnkcrXuRnFsXCCMOtKX3CWAmQvUBYwzKPvvz6N8HEcBYOEJ4UmcRetJ-zVpD2z30vafx7cP9mUw_XqcPLWT9wvb731_9pKPrr26mZ5dTzod2xuO39J0OBmNxvfntn-XRotoTqv9uJr_0xwqbW6UCttOcXdrp7BWdEImiKMxFcB9HlR8RgLfY4JrqrRSWArOKgpEyANNtAh0KJQUugoMPI9gWaE0AEZzaGVWe6qMVqZWrjdOmiYdLB_XW63fw0ABk5RbmnHhXsPUjqKUPGxGB6rZKnPuYSmlIPQHcTNxBA |
| ClassificationCodes | R614 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3969/j.issn.0253-9896.2015.03.011 |
| DatabaseName | 维普期刊资源整合服务平台 中文科技期刊数据库-CALIS站点 中文科技期刊数据库-7.0平台 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Changes of motilin concentrations in plasma and upper gastrointestinal tract in rat model of acute incisional pain |
| DocumentTitle_FL | Changes of motilin concentrations in plasma and upper gastrointestinal tract in rat model of acute incisional pain |
| EndPage | 266 |
| ExternalDocumentID | tjyy201503012 664199972 |
| GrantInformation_xml | – fundername: 天津市卫生局科技基金资助项目 funderid: (2012KY03) |
| GroupedDBID | -05 2B. 2C~ 2RA 5XA 5XF 92F 92I 92L ABDBF ACGFS ALMA_UNASSIGNED_HOLDINGS CCEZO CIEJG CQIGP CW9 EOJEC F5P OBODZ TCJ TGQ U1G U5O W91 ~WA 4A8 93N ABJNI ACUHS PSX |
| ID | FETCH-LOGICAL-c572-f1370686bd852b84576f3afaa19765da07c6bf2f7bfc7a97fe05044219d33b053 |
| ISSN | 0253-9896 |
| IngestDate | Thu May 29 04:06:52 EDT 2025 Wed Feb 14 10:31:13 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | 急性切口痛 胃 血浆 促胃动素 stomach plasma duodenum 十二指肠 motilin acute incisional pain |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c572-f1370686bd852b84576f3afaa19765da07c6bf2f7bfc7a97fe05044219d33b053 |
| Notes | motilin;stomach;duodenum;plasma;acute incisional pain Objective To observe changes of motilin（MTL） levels in gastric body, duodenum and plasma in rat model of acute incisional pain.Methods A total of 156 healthy male adult SD rats,weighing 180-220 g,were randomized into two groups：control group （group C,n=78） and incisional pain group （group P,n=78）,Rats in P group received incision on the right plantaris. Values of paw withdrawal mechanical threshold （PWMT） and paw withdrawal thermal latency （PWTL） at dif-ferent time points of 24 hours before operation （T0） and 1 hour （T1）,6 hours （T2）,24 hours（T3）,48 hours （T4） and 72 hours （T5） after operation were measured in six rats chosen randomly from each group. Twelve rats were chosen from each group at T 0-5, and sacrificed. The MTL levels in plasma, the mucosal tissues of gastric body and duodenum were detected by ELISA. Re-sults Compared with group C, PWMT and PWTL were significantly decreased at T1-4 in group P. The MTL levels were sig-nificantly decreased in pla |
| PageCount | 4 |
| ParticipantIDs | wanfang_journals_tjyy201503012 chongqing_primary_664199972 |
| PublicationCentury | 2000 |
| PublicationDate | 2015 |
| PublicationDateYYYYMMDD | 2015-01-01 |
| PublicationDate_xml | – year: 2015 text: 2015 |
| PublicationDecade | 2010 |
| PublicationTitle | 天津医药 |
| PublicationTitleAlternate | Tianjin Medical Journal |
| PublicationTitle_FL | Tianjin Medical Journal |
| PublicationYear | 2015 |
| Publisher | 天津医科大学三中心临床学院 邮编300170%天津市第三中心医院重症医学科、天津市人工细胞重点实验室%天津医科大学附属肿瘤医院麻醉科 |
| Publisher_xml | – name: 天津医科大学三中心临床学院 邮编300170%天津市第三中心医院重症医学科、天津市人工细胞重点实验室%天津医科大学附属肿瘤医院麻醉科 |
| SSID | ssib017477491 ssib001104050 ssib002263120 ssj0051502 ssib051371343 ssib039893103 ssib058494496 |
| Score | 1.9802184 |
| Snippet | 目的：观察急性切口痛大鼠血浆、胃体及十二指肠胃动素（MTL）水平的变化。方法 SPF级健康雄性SD大鼠156只，6～8周龄，体质量180～220 g，采用随机数字表法将其分为2组（n=78）：对照组（C组）和切口痛组（P组）。P组行右足跖肌切口。2组先随机各取6只大鼠，于术前24 h（T0）、术后1 h（T1）、6... R614; 目的：观察急性切口痛大鼠血浆、胃体及十二指肠胃动素（MTL）水平的变化。方法 SPF级健康雄性SD大鼠156只，6～8周龄，体质量180～220 g，采用随机数字表法将其分为2组（n=78）：对照组（C组）和切口痛组（P组）。P组行右足跖肌切口。2组先随机各取6只大鼠，于术前24 h（T0）、术后1... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 263 |
| SubjectTerms | 促胃动素 十二指肠 急性切口痛 胃 血浆 |
| Title | 急性切口痛大鼠血浆及上消化道胃动素表达的变化 |
| URI | http://lib.cqvip.com/qk/92492X/201503/664199972.html https://d.wanfangdata.com.cn/periodical/tjyy201503012 |
| Volume | 43 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1Na9RAdCgtFC_iJ9Zq6aFzKqm7mY_MHCfbLEXQU4XeliSbtHjY-rE9tKdKRcsi7EFQ0Yui0v4AFQ_SP-DfMNv2X_jeZJpdoRQVhvAyM2_em3mTmTfJey-EzKUSPwxyARII2h4H0EtgI_P8RKex4Hkty6y1xV25dI_fXhErY2M_R6yWNrrJQrp1ql_J_0gV8kCu6CX7D5KtGoUMgEG-cAUJw_WvZEwjiZYKRpwAAY0EVYqqEmhSw2gUUA0pxBzDbR1NwwY1NRopauqICOgh1JcOSxkacRoqC0CRxDaxqEG1RHRVp5ohumKYsMhQo5BWyIctY46iYYQJ2TBUcUdCDxsc1Y9PmNSWLrdds9XC0JJbpKYyRbZtC0yR5V2H8wgBLV1DctB3ZcqssrfAAfDdmHf1TdMCwrEJ_dCN0ZcgpQOoWyV9wTytHLNuSS8jP7mpy0bXZ7eaZu5OnraLMC213UWQwEJFAO0AhY2I67aHP-N0S8kxpEMA-sAETP-6GCcTJlwMm0PtFI6-NTHqdixZfaitw9kQHpVh6CIGRPEvcCf3os7Q8bdSNEATtSa1FYOTZM5xf-ss3jGKyNp6Z_Uh6EbWVa2Tx53VEa1q-QI5745Ds6ac2xfJ2NbaJTJ5xxl8XCbhYPvzYHuv2H1e9D8evn5XfNo7_vH-6MP24Ouzot_79b03-LZbvHh1_OTl0c5O0ds__AKl-0cHB4dvnxb9N1B0hSw3o-XGkud---GlIvC9HLqJfktJWwk_URwOxDmL8ziug-Ys2nEtSGWS-3mQ5GkQ6yDPYEw5h523zRiMErtKxjvrnewamc0DqX3OcpZxn8dKoC4O608sslzJwE-nyHQ1Eq0HZXSXViXHKTLjxqblnvnHre79zU0cSnyR4F8_E32anMOa5eu6G2S8-2gjuwkKbDeZcRPjN8TCd94 |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E6%80%A5%E6%80%A7%E5%88%87%E5%8F%A3%E7%97%9B%E5%A4%A7%E9%BC%A0%E8%A1%80%E6%B5%86%E5%8F%8A%E4%B8%8A%E6%B6%88%E5%8C%96%E9%81%93%E8%83%83%E5%8A%A8%E7%B4%A0%E8%A1%A8%E8%BE%BE%E7%9A%84%E5%8F%98%E5%8C%96&rft.jtitle=%E5%A4%A9%E6%B4%A5%E5%8C%BB%E8%8D%AF&rft.au=%E8%B5%B5%E5%86%9B+%E5%BE%90%E7%A3%8A+%E5%BC%A0%E7%91%9C+%E5%86%AF%E5%85%A8%E8%83%9C&rft.date=2015&rft.issn=0253-9896&rft.volume=43&rft.issue=3&rft.spage=263&rft.epage=266&rft_id=info:doi/10.3969%2Fj.issn.0253-9896.2015.03.011&rft.externalDocID=664199972 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F92492X%2F92492X.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Ftjyy%2Ftjyy.jpg |