Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent

• Published in: The American journal of clinical nutrition Vol. 91; no. 6; pp. 1634 - 1641
• Main Authors: Bao, Bin, Prasad, Ananda S, Beck, Frances WJ, Fitzgerald, James T, Snell, Diane, Bao, Ginny W, Singh, Tapinder, Cardozo, Lavoisier J
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Clinical Nutrition 01.06.2010; American Society for Nutrition; American Society for Clinical Nutrition, Inc
• Subjects: administration & dosage; Aged; Aged, 80 and over; anti-inflammatory activity; antioxidant activity; atheroprotective activity; atherosclerosis; Atherosclerosis - blood; Atherosclerosis - immunology; Atherosclerosis - prevention & control; Biological and medical sciences; blood; C-reactive protein; C-Reactive Protein - metabolism; Chemokine CCL2; Chemokine CCL2 - blood; Cytokines; Cytokines - blood; dietary mineral supplements; dietary minerals; Dietary Supplements; DNA-Binding Proteins; Double-Blind Method; drug effects; elderly; elderly nutrition; Endothelial Cells; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; HL-60 Cells; Humans; immunology; inflammation; Interleukin-6; Interleukin-6 - blood; Intracellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins - blood; lipid peroxidation; Lipid Peroxidation - drug effects; Lipids; Male; Malondialdehyde; Malondialdehyde - blood; metabolism; Middle Aged; NF-kappa B; NF-kappa B - blood; Nuclear Proteins; Nuclear Proteins - blood; Nutrition; Older people; Original Research Communications; oxidative stress; Oxidative Stress - drug effects; Phospholipases A2; Phospholipases A2 - blood; Plasma; PPAR alpha; PPAR alpha - blood; prevention & control; protective effect; Proteins; Risk factors; Tumor Necrosis Factor alpha-Induced Protein 3; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha - blood; Vascular Cell Adhesion Molecule-1; Vascular Cell Adhesion Molecule-1 - blood; Veins & arteries; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vitamins, Minerals, and Phytochemicals; Zinc; Zinc - administration & dosage; Zinc - blood; Human; Decrease; Cytokine; Lipids; Inflammation; C reactive protein; Elderly; Zinc; Peroxidation

BACKGROUND: Chronic inflammation and oxidative stress are common risk factors for atherosclerosis. Zinc is an essential micronutrient that can function as an antiinflammatory and antioxidative agent, and as such, it may have atheroprotective properties. OBJECTIVE: We hypothesized that zinc down-regu...