Identification of novel proteins for lacunar stroke by integrating genome-wide association data and human brain proteomes

• Published in: BMC medicine Vol. 20; no. 1; pp. 1 - 11
• Main Authors: Zhang, Chengcheng, Qin, Fengqin, Li, Xiaojing, Du, Xiangdong, Li, Tao
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 23.06.2022; BioMed Central; BMC
• Subjects: Aldehyde dehydrogenase; ALDH2; Alzheimer's disease; Astrocytes; Bayesian analysis; Biological markers; Biomarkers; Brain; Brain research; CAND2; Conditional probability; Consortia; Functional genomics; Gene expression; Genes; Genetic aspects; Genome-wide association studies; Genomes; Genomics; Glutamatergic transmission; Health aspects; Health risks; Human brain proteomes; Hypotheses; ICA1L; Identification and classification; Lacunar stroke; Magnetic resonance imaging; Methods; Neurons; Peptides; Proteins; Proteomes; Proteomics; Quality control; Risk factors; Stroke; Stroke (Disease); Therapeutic targets; Transcriptomes; γ-Aminobutyric acid; China; United Kingdom > UK

Background Previous genome-wide association studies (GWAS) have identified numerous risk genes for lacunar stroke, but it is challenging to decipher how they confer risk for the disease. We employed an integrative analytical pipeline to efficiently transform genetic associations to identify novel pr...