GABA receptor subunit distribution and FMRP–mGluR5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism

• Published in: Schizophrenia research Vol. 167; no. 1-3; pp. 42 - 56
• Main Authors: Fatemi, S. Hossein, Folsom, Timothy D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2015
• Subjects: Animals; Autistic Disorder - pathology; Bipolar disorder; Cerebellum; Cerebellum - metabolism; Disease Models, Animal; FMRP; Fragile X Mental Retardation Protein - metabolism; GABA; Humans; mGluR5; Mice; Mood Disorders - pathology; Psychiatry; Receptor, Metabotropic Glutamate 5 - metabolism; Receptors, GABA - metabolism; Schizophrenia; Schizophrenia - pathology; Signal Transduction - physiology; Cerebellum; GABA; Schizophrenia; Bipolar disorder; FMRP; mGluR5

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain. GABAergic receptor abnormalities have been documented in several major psychiatric disorders including schizophrenia, mood disorders, and autism. Abnormal expression of mRNA and protein for multiple GABA receptors h...