Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

• Published in: British journal of cancer Vol. 115; no. 2; pp. 266 - 272
• Main Authors: Jarvis, David, Mitchell, Jonathan S, Law, Philip J, Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hänninen, Ulrika A, Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Kaprio, Jaakko, Eriksson, Johan G, Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Järvinen, Heikki, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Meklin, Jukka-Pekka, Al-Tassan, Nada A, Palles, Claire, Martin, Lynn, Barclay, Ella, Farrington, Susan M, Timofeeva, Maria N, Meyer, Brian F, Wakil, Salma M, Campbell, Harry, Smith, Christopher G, Idziaszczyk, Shelley, Maughan, Timothy S, Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D, Win, Aung K, Hopper, John L, Jenkins, Mark A, Lindor, Noralane M, Newcomb, Polly A, Gallinger, Steve, Conti, David, Schumacher, Fred, Casey, Graham, Taipale, Jussi, Aaltonen, Lauri A, Cheadle, Jeremy P, Dunlop, Malcolm G, Tomlinson, Ian P, Houlston, Richard S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.07.2016; Nature Publishing Group
• Subjects: 692/499; 692/699/67/1504/1885; 692/699/67/68; 692/700/139/2818; Adiposity - genetics; Adult; Biomedical and Life Sciences; Biomedicine; Birth weight; Body mass index; Cancer Research; Colorectal cancer; Colorectal Neoplasms - complications; Colorectal Neoplasms - genetics; Confounding (Statistics); Drug Resistance; Epidemiology; Female; Genetics and Genomics; Genome-Wide Association Study; Genomes; Humans; Lifestyles; Male; Medicin och hälsovetenskap; Middle Aged; Molecular Medicine; Obesity; Observational studies; Oncology; Polymorphism, Single Nucleotide; Random Allocation; Weight control; adiposity; Mendelian randomisation; colorectal cancer

Background: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian randomisation (MR) analysis to examine the relationship between adip...