Poor immunogenicity of BCG in helminth infected population is associated with increased in vitro TGF-β production

• Published in: Vaccine Vol. 26; no. 31; pp. 3897 - 3902
• Main Authors: Elias, Daniel, Britton, Sven, Aseffa, Abraham, Engers, Howard, Akuffo, Hannah
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 23.07.2008; Elsevier
• Subjects: Adolescent; Adult; Allergy and Immunology; Animals; Anthelmintics - therapeutic use; Applied microbiology; Bacterial diseases; BCG; Biological and medical sciences; Cells, Cultured; Fundamental and applied biological sciences. Psychology; Helminthiasis - drug therapy; Helminthiasis - immunology; Helminths; Human bacterial diseases; Humans; Infectious diseases; Interferon-gamma - biosynthesis; Interleukin-12 - biosynthesis; Interleukin-4 - biosynthesis; Interleukin-5 - biosynthesis; Leukocytes, Mononuclear - immunology; Medical sciences; Microbiology; Middle Aged; Mycobacterium; Mycobacterium bovis - immunology; Placebos - administration & dosage; TGF-β; Transforming Growth Factor beta - biosynthesis; Tuberculosis; Tuberculosis and atypical mycobacterial infections; Tuberculosis Vaccines - immunology; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); TGF-β; Tuberculosis; Helminths; BCG; Infection; Immunogenicity; Bacteriosis; Mycobacterial infection; In vitro

The only vaccine available against tuberculosis (TB), BCG, so effective in experimental animal models, has been under scrutiny for a long time owing to its variable efficacy against pulmonary tuberculosis in adults. In this study, we evaluated whether anti-helminthic therapy prior to BCG vaccination...