Association of monocyte tumor necrosis factor α expression and serum inflammatory biomarkers with walking impairment in peripheral artery disease

• Published in: Journal of vascular surgery Vol. 61; no. 1; pp. 155 - 161
• Main Authors: Pande, Reena L., Brown, Jonathan, Buck, Stewart, Redline, Whitney, Doyle, Jeanne, Plutzky, Jorge, Creager, Mark A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2015
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers - blood; Case-Control Studies; Cross-Sectional Studies; Exercise Test; Exercise Tolerance; Female; Humans; Inflammation Mediators - blood; Intermittent Claudication - blood; Intermittent Claudication - diagnosis; Intermittent Claudication - genetics; Intermittent Claudication - immunology; Intermittent Claudication - physiopathology; Male; Middle Aged; Monocytes - metabolism; Peripheral Arterial Disease - blood; Peripheral Arterial Disease - diagnosis; Peripheral Arterial Disease - genetics; Peripheral Arterial Disease - immunology; Peripheral Arterial Disease - physiopathology; Predictive Value of Tests; Real-Time Polymerase Chain Reaction; RNA, Messenger - blood; Severity of Illness Index; Surgery; Time Factors; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - genetics; Walking

Inflammation contributes to the development of peripheral artery disease (PAD) and may contribute to intermittent claudication by adversely affecting vascular and skeletal muscle function. We explored the association of inflammation to maximal walking time (MWT) in patients with claudication. Circul...