Determination of dextromethorphan in human plasma using pipette tip solid-phase extraction and gas chromatography–mass spectrometry
Dextromethorphan was extracted from human plasma samples (100 μL) using MonoTip C 18 tips, which are packed with C 18 -bonded monolithic silica gel that is attached to the inside of the tip. The samples, which contained dextromethorphan and trimeprazine as an internal standard (IS), were mixed with...
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| Published in | Analytical and bioanalytical chemistry Vol. 401; no. 7; pp. 2215 - 2223 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Berlin/Heidelberg
Springer-Verlag
01.10.2011
Springer |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1618-2642 1618-2650 1618-2650 |
| DOI | 10.1007/s00216-011-5324-5 |
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| Abstract | Dextromethorphan was extracted from human plasma samples (100 μL) using MonoTip C
18
tips, which are packed with C
18
-bonded monolithic silica gel that is attached to the inside of the tip. The samples, which contained dextromethorphan and trimeprazine as an internal standard (IS), were mixed with 200 μL of distilled water and 50 μL of 1 mol/L glycine–sodium hydroxide buffer (pH 10). The mixture was extracted to the C
18
phase of the tip by 20 sequential aspirating/dispensing cycles using a manual micropipettor. The analytes retained on the C
18
phase were then eluted with methanol by five sequential aspirating/dispensing cycles. The eluate was injected directly into a gas chromatograph and detected by a mass spectrometer with selected ion monitoring in positive electron ionization mode. An Equity-5 fused silica capillary column (30 m × 0.32 mm i.d., film thickness 0.5 μm) gave adequate separation of the dextromethorphan, IS, and impurities. The recoveries of dextromethorphan and the IS spiked into plasma were >87.4%. The regression equation for dextromethorphan showed excellent linearity from 2.5 to 320 ng/mL of plasma, and the limit of detection was 1.25 ng/mL of plasma. The intraday and interday coefficients of variation were less than 10.5% and 14.7%, respectively. The accuracy ranged from 91.9% to 107%. The validated method was successfully used to quantify the plasma concentration of dextromethorphan in a human subject after oral administration of the drug. |
|---|---|
| AbstractList | Dextromethorphan was extracted from human plasma samples (100 μL) using MonoTip C
18
tips, which are packed with C
18
-bonded monolithic silica gel that is attached to the inside of the tip. The samples, which contained dextromethorphan and trimeprazine as an internal standard (IS), were mixed with 200 μL of distilled water and 50 μL of 1 mol/L glycine–sodium hydroxide buffer (pH 10). The mixture was extracted to the C
18
phase of the tip by 20 sequential aspirating/dispensing cycles using a manual micropipettor. The analytes retained on the C
18
phase were then eluted with methanol by five sequential aspirating/dispensing cycles. The eluate was injected directly into a gas chromatograph and detected by a mass spectrometer with selected ion monitoring in positive electron ionization mode. An Equity-5 fused silica capillary column (30 m × 0.32 mm i.d., film thickness 0.5 μm) gave adequate separation of the dextromethorphan, IS, and impurities. The recoveries of dextromethorphan and the IS spiked into plasma were >87.4%. The regression equation for dextromethorphan showed excellent linearity from 2.5 to 320 ng/mL of plasma, and the limit of detection was 1.25 ng/mL of plasma. The intraday and interday coefficients of variation were less than 10.5% and 14.7%, respectively. The accuracy ranged from 91.9% to 107%. The validated method was successfully used to quantify the plasma concentration of dextromethorphan in a human subject after oral administration of the drug. Dextromethorphan was extracted from human plasma samples (100 μL) using MonoTip [C.sub.18] tips, which are packed with [C.sub.18]-bonded monolithic silica gel that is attached to the inside of the tip. The samples, which contained dextromethorphan and trimeprazine as an internal standard (IS), were mixed with 200 μL of distilled water and 50 μL of 1 mol/L glycine-sodium hydroxide buffer (pH 10). The mixture was extracted to the [C.sub.18] phase of the tip by 20 sequential aspirating/dispensing cycles using a manual micropipettor. The analytes retained on the [C.sub.18] phase were then eluted with methanol by five sequential aspirating/dispensing cycles. The eluate was injected directly into a gas chromatograph and detected by a mass spectrometer with selected ion monitoring in positive electron ionization mode. An Equity-5 fused silica capillary column (30 mx0.32 mm i.d., film thickness 0.5 μm) gave adequate separation of the dextromethorphan, IS, and impurities. The recoveries of dextromethorphan and the IS spiked into plasma were >87.4%. The regression equation for dextromethorphan showed excellent linearity from 2.5 to 320 ng/mL of plasma, and the limit of detection was 1.25 ng/mL of plasma. The intraday and interday coefficients of variation were less than 10.5% and 14.7%, respectively. The accuracy ranged from 91.9% to 107%. The validated method was successfully used to quantify the plasma concentration of dextromethorphan in a human subject after oral administration of the drug. Dextromethorphan was extracted from human plasma samples (100 μL) using MonoTip C(18) tips, which are packed with C(18)-bonded monolithic silica gel that is attached to the inside of the tip. The samples, which contained dextromethorphan and trimeprazine as an internal standard (IS), were mixed with 200 μL of distilled water and 50 μL of 1 mol/L glycine-sodium hydroxide buffer (pH 10). The mixture was extracted to the C(18) phase of the tip by 20 sequential aspirating/dispensing cycles using a manual micropipettor. The analytes retained on the C(18) phase were then eluted with methanol by five sequential aspirating/dispensing cycles. The eluate was injected directly into a gas chromatograph and detected by a mass spectrometer with selected ion monitoring in positive electron ionization mode. An Equity-5 fused silica capillary column (30 m × 0.32 mm i.d., film thickness 0.5 μm) gave adequate separation of the dextromethorphan, IS, and impurities. The recoveries of dextromethorphan and the IS spiked into plasma were >87.4%. The regression equation for dextromethorphan showed excellent linearity from 2.5 to 320 ng/mL of plasma, and the limit of detection was 1.25 ng/mL of plasma. The intraday and interday coefficients of variation were less than 10.5% and 14.7%, respectively. The accuracy ranged from 91.9% to 107%. The validated method was successfully used to quantify the plasma concentration of dextromethorphan in a human subject after oral administration of the drug. Dextromethorphan was extracted from human plasma samples (100 μL) using MonoTip C(18) tips, which are packed with C(18)-bonded monolithic silica gel that is attached to the inside of the tip. The samples, which contained dextromethorphan and trimeprazine as an internal standard (IS), were mixed with 200 μL of distilled water and 50 μL of 1 mol/L glycine-sodium hydroxide buffer (pH 10). The mixture was extracted to the C(18) phase of the tip by 20 sequential aspirating/dispensing cycles using a manual micropipettor. The analytes retained on the C(18) phase were then eluted with methanol by five sequential aspirating/dispensing cycles. The eluate was injected directly into a gas chromatograph and detected by a mass spectrometer with selected ion monitoring in positive electron ionization mode. An Equity-5 fused silica capillary column (30 m × 0.32 mm i.d., film thickness 0.5 μm) gave adequate separation of the dextromethorphan, IS, and impurities. The recoveries of dextromethorphan and the IS spiked into plasma were >87.4%. The regression equation for dextromethorphan showed excellent linearity from 2.5 to 320 ng/mL of plasma, and the limit of detection was 1.25 ng/mL of plasma. The intraday and interday coefficients of variation were less than 10.5% and 14.7%, respectively. The accuracy ranged from 91.9% to 107%. The validated method was successfully used to quantify the plasma concentration of dextromethorphan in a human subject after oral administration of the drug.Dextromethorphan was extracted from human plasma samples (100 μL) using MonoTip C(18) tips, which are packed with C(18)-bonded monolithic silica gel that is attached to the inside of the tip. The samples, which contained dextromethorphan and trimeprazine as an internal standard (IS), were mixed with 200 μL of distilled water and 50 μL of 1 mol/L glycine-sodium hydroxide buffer (pH 10). The mixture was extracted to the C(18) phase of the tip by 20 sequential aspirating/dispensing cycles using a manual micropipettor. The analytes retained on the C(18) phase were then eluted with methanol by five sequential aspirating/dispensing cycles. The eluate was injected directly into a gas chromatograph and detected by a mass spectrometer with selected ion monitoring in positive electron ionization mode. An Equity-5 fused silica capillary column (30 m × 0.32 mm i.d., film thickness 0.5 μm) gave adequate separation of the dextromethorphan, IS, and impurities. The recoveries of dextromethorphan and the IS spiked into plasma were >87.4%. The regression equation for dextromethorphan showed excellent linearity from 2.5 to 320 ng/mL of plasma, and the limit of detection was 1.25 ng/mL of plasma. The intraday and interday coefficients of variation were less than 10.5% and 14.7%, respectively. The accuracy ranged from 91.9% to 107%. The validated method was successfully used to quantify the plasma concentration of dextromethorphan in a human subject after oral administration of the drug. Dextromethorphan was extracted from human plasma samples (100 Delta *mL) using MonoTip C18 tips, which are packed with C18-bonded monolithic silica gel that is attached to the inside of the tip. The samples, which contained dextromethorphan and trimeprazine as an internal standard (IS), were mixed with 200 Delta *mL of distilled water and 50 Delta *mL of 1 mol/L glycine--sodium hydroxide buffer (pH 10). The mixture was extracted to the C18 phase of the tip by 20 sequential aspirating/dispensing cycles using a manual micropipettor. The analytes retained on the C18 phase were then eluted with methanol by five sequential aspirating/dispensing cycles. The eluate was injected directly into a gas chromatograph and detected by a mass spectrometer with selected ion monitoring in positive electron ionization mode. An Equity-5 fused silica capillary column (30 mX0.32 mm i.d., film thickness 0.5 Delta *mm) gave adequate separation of the dextromethorphan, IS, and impurities. The recoveries of dextromethorphan and the IS spiked into plasma were >87.4%. The regression equation for dextromethorphan showed excellent linearity from 2.5 to 320 ng/mL of plasma, and the limit of detection was 1.25 ng/mL of plasma. The intraday and interday coefficients of variation were less than 10.5% and 14.7%, respectively. The accuracy ranged from 91.9% to 107%. The validated method was successfully used to quantify the plasma concentration of dextromethorphan in a human subject after oral administration of the drug. Dextromethorphan was extracted from human plasma samples (100 μL) using MonoTip [C.sub.18] tips, which are packed with [C.sub.18]-bonded monolithic silica gel that is attached to the inside of the tip. The samples, which contained dextromethorphan and trimeprazine as an internal standard (IS), were mixed with 200 μL of distilled water and 50 μL of 1 mol/L glycine-sodium hydroxide buffer (pH 10). The mixture was extracted to the [C.sub.18] phase of the tip by 20 sequential aspirating/dispensing cycles using a manual micropipettor. The analytes retained on the [C.sub.18] phase were then eluted with methanol by five sequential aspirating/dispensing cycles. The eluate was injected directly into a gas chromatograph and detected by a mass spectrometer with selected ion monitoring in positive electron ionization mode. An Equity-5 fused silica capillary column (30 mx0.32 mm i.d., film thickness 0.5 μm) gave adequate separation of the dextromethorphan, IS, and impurities. The recoveries of dextromethorphan and the IS spiked into plasma were >87.4%. The regression equation for dextromethorphan showed excellent linearity from 2.5 to 320 ng/mL of plasma, and the limit of detection was 1.25 ng/mL of plasma. The intraday and interday coefficients of variation were less than 10.5% and 14.7%, respectively. The accuracy ranged from 91.9% to 107%. The validated method was successfully used to quantify the plasma concentration of dextromethorphan in a human subject after oral administration of the drug. Keywords Dextromethorphan * Solid-phase extraction * Pipette tip . Gas chromatography* Mass spectrometry |
| Audience | Academic |
| Author | Terada, Masaru Kurosaki, Kunihiko Lee, Xiao-Pen Sato, Keizo Uchigasaki, Seisaku Hasegawa, Chika Kumazawa, Takeshi |
| Author_xml | – sequence: 1 givenname: Chika surname: Hasegawa fullname: Hasegawa, Chika email: chika99@med.toho-u.ac.jp organization: Department of Legal Medicine, Toho University School of Medicine – sequence: 2 givenname: Takeshi surname: Kumazawa fullname: Kumazawa, Takeshi organization: Department of Legal Medicine, Showa University School of Medicine – sequence: 3 givenname: Seisaku surname: Uchigasaki fullname: Uchigasaki, Seisaku organization: Department of Legal Medicine, Nihon University School of Medicine – sequence: 4 givenname: Xiao-Pen surname: Lee fullname: Lee, Xiao-Pen organization: Department of Legal Medicine, Showa University School of Medicine – sequence: 5 givenname: Keizo surname: Sato fullname: Sato, Keizo organization: Department of Legal Medicine, Showa University School of Medicine – sequence: 6 givenname: Masaru surname: Terada fullname: Terada, Masaru organization: Department of Legal Medicine, Toho University School of Medicine – sequence: 7 givenname: Kunihiko surname: Kurosaki fullname: Kurosaki, Kunihiko organization: Department of Legal Medicine, Toho University School of Medicine |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24558940$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21874269$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.3122/jabfm.19.3.320 10.1007/s00216-007-1460-3 10.1016/j.cca.2010.05.046 10.1016/S0378-4347(97)00308-3 10.1016/j.chroma.2011.02.070 10.1016/j.ab.2005.11.015 10.1016/j.jpba.2006.12.025 10.1016/j.chroma.2004.03.025 10.1002/rcm.2335 10.1002/rcm.3613 10.1016/0379-0738(88)90230-7 10.1007/s11095-007-9291-7 10.1002/bmc.1234 10.1021/pr050434z 10.1016/0731-7085(91)80203-L 10.1001/archpedi.160.12.1217 10.1007/s11419-010-0097-7 10.1002/jssc.200700627 10.1177/002580248902900309 10.1001/archfami.8.2.99 10.1093/jat/32.3.220 10.1111/j.1365-2125.2010.03747.x 10.1177/000992280504400702 10.1093/jaoac/88.6.1655 10.1016/j.jchromb.2006.03.059 10.1021/pr0601178 10.1176/appi.ajp.157.2.304 10.1093/jat/34.8.506 10.1002/(SICI)1096-9888(200001)35:1<33::AID-JMS909>3.0.CO;2-T 10.1016/S1570-0232(03)00269-1 10.1016/S0731-7085(95)01749-6 10.1002/jssc.200401942 |
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| Keywords | Pipette tip Gas chromatography Dextromethorphan Mass spectrometry Solid-phase extraction Capillary column Water Solid phase extraction Plasma Electron impact ionization Impurity Internal standard Glycine Silica Mixture Chemical enrichment Sodium hydroxide Accuracy Sample preparation Detection limit pH Silica gel Monitoring Variation coefficient Methanol Human Drug Elution Sample Use Concentration Method Pipette Positive ion Thickness Linearity |
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| References | van den BroekISparidansRWHuitemaADRSchellensJHMBeijnenJHJ Chromatogr B2006837495810.1016/j.jchromb.2006.03.059 HasegawaCKumazawaTLeeXPMarumoAShinmenNSenoHSatoKAnal Bioanal Chem200738956357010.1007/s00216-007-1460-31:CAS:528:DC%2BD2sXpsFSjtLw%3D PriceLHLebelJAm J Psychiatry200015730410.1176/appi.ajp.157.2.3041:STN:280:DC%2BD3c7jslOhtw%3D%3D EkströmSWallmanLHökDMarko-VargaGLaurellTJ Proteome Res200651071108110.1021/pr050434z SpanakisMVizirianakisISMironidou-TzouvelekiMNiopasIBiomed Chromatogr2009231131113710.1002/bmc.12341:CAS:528:DC%2BD1MXht1OrtL3N WenkMTodescoLKellerBFollathFJ Pharm Biomed Anal1991934134410.1016/0731-7085(91)80203-L1:CAS:528:DyaK3MXkvVCks7w%3D SchwartzRHClin Pediatr (Phila)20054456556810.1177/000992280504400702 LevineBPhippsRJNasoCFahieKFowlerDJ Anal Toxicol2010345065091:CAS:528:DC%2BC3cXht1KitrvL RodriguesWCWangGMooreCAgrawalAVincentMJSoaresJRJ Anal Toxicol2008322202261:CAS:528:DC%2BD1cXjslyrsLw%3D LynchKBreaudARVandenbergheHWuAHBClarkeWClin Chim Acta20104111474148110.1016/j.cca.2010.05.0461:CAS:528:DC%2BC3cXptlGjtrk%3D SenoHHattoriHIizumiTKumazawaTSuzukiOJpn J Forensic Toxicol1992102362401:CAS:528:DyaK3sXltFSlu70%3D KumazawaTHasegawaCLeeXPHaraKSenoHSuzukiOSatoKJ Pharm Biomed Anal20074460260710.1016/j.jpba.2006.12.0251:CAS:528:DC%2BD2sXmtlans7g%3D WaCCernyRHageDSAnal Biochem200634922924110.1016/j.ab.2005.11.0151:CAS:528:DC%2BD28XhtFWhs7c%3D BartolettiRABelpaireFMRosseelMTJ Pharm Biomed Anal1996141281128610.1016/S0731-7085(95)01749-61:CAS:528:DyaK28Xks1Sju70%3D SchulzMSchmoldtAPharmazie2003584474741:CAS:528:DC%2BD3sXlsVOjs7w%3D HasegawaCKumazawaTLeeXPFujishiroMKurikiAMarumoASenoHSatoKRapid Commun Mass Spectrom20062053754310.1002/rcm.23351:CAS:528:DC%2BD28XhslOnsrs%3D EichholdTHQuijanoMSeibelWLCruzeCADobsonRLMWehmeyerKRJ Chromatogr B199769814715410.1016/S0378-4347(97)00308-31:CAS:528:DyaK2sXlslems74%3D LeeXPHasegawaCKumazawaTShinmenNShojiYSenoHSatoKJ Sep Sci2008312265227110.1002/jssc.2007006271:CAS:528:DC%2BD1cXptVaqsb8%3D KumazawaTHasegawaCUchigasakiSLeeXPSuzukiOSatoKJ Chromatogr A201112182521252710.1016/j.chroma.2011.02.0701:CAS:528:DC%2BC3MXkvFWrt74%3D MarumoAKumazawaTLeeXPFujimakiKKurikiAHasegawaCSatoKSenoHSuzukiOJ AOAC Int200588165516601:CAS:528:DC%2BD2MXhtlWqsLvO MiyazakiSMorisatoKIshizukaNMinakuchiHShintaniYFurunoMNakanishiKJ Chromatogr A20041043192510.1016/j.chroma.2004.03.0251:CAS:528:DC%2BD2cXlsVSlu7c%3D ViswanathanCTBansalSBoothBDeStefanoAJRoseMJSailstadJShahVPSkellyJPSwannPGWeinerRPharm Res2007241962197310.1007/s11095-007-9291-71:CAS:528:DC%2BD2sXhtVagt7fF MonteAAChuangRBodmerMBr J Clin Pharmacol20107079479810.1111/j.1365-2125.2010.03747.x1:CAS:528:DC%2BC3MXhsVCgs7g%3D BrynerJKWangUKHuiJWBedodoMMacDougallCAndersonIBArch Pediatr Adolesc Med20061601217122210.1001/archpedi.160.12.1217 DesaiSAldeaDDaneelsESolimanMBraksmajerASKopes-KerrCPJ Am Board Fam Med20061932032310.3122/jabfm.19.3.320 SaitoHOdaYSatoTKuromitsuJIshihamaYJ Proteome Res200651803180710.1021/pr06011781:CAS:528:DC%2BD28XlvFKgtL4%3D RammerLHolmgrenPSandlerHForensic Sci Int19883723323610.1016/0379-0738(88)90230-71:STN:280:DyaL1czhtlyisA%3D%3D KumazawaTHasegawaCLeeX-PSatoKForensic Toxicol201028616810.1007/s11419-010-0097-71:CAS:528:DC%2BC3cXpt1Oitbg%3D HuangZZhangSJ Chromatogr B200379224124710.1016/S1570-0232(03)00269-11:CAS:528:DC%2BD3sXlt1akt7w%3D U.S. Department of Health and Human Services, Food and Drugs Administration, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM) (2001) Guidance for industry: bioanalytical method validation. http://www.labcompliance.de/documents/FDA/FDA-Others/Laboratory/f-507-bioanalytical-4252fnl.pdf Accessed 1 June SantagatiNAGottiRRonsisvalleGJ Sep Sci2005281157116210.1002/jssc.2004019421:CAS:528:DC%2BD2MXnvVSqtb4%3D UmezawaHLeeX-PArimaYHasegawaCMarumoAKumazawaTSatoKRapid Commun Mass Spectrom2008222333234110.1002/rcm.36131:CAS:528:DC%2BD1cXpsFOnur8%3D SuzukiOKumazawaTSenoHHattoriHMed Sci Law1989292422481:STN:280:DyaL1MzmsVWhsg%3D%3D CranstonJWYoastRArch Fam Med199989910010.1001/archfami.8.2.991:STN:280:DyaK1M3gt1ajtw%3D%3D SenoHKumazawaTIshiiAMatsushimaHWatanabe-SuzukiKSuzukiOJ Mass Spectrom200035333810.1002/(SICI)1096-9888(200001)35:1<33::AID-JMS909>3.0.CO;2-T1:CAS:528:DC%2BD3cXhtVans7c%3D RA Bartoletti (5324_CR32) 1996; 14 K Lynch (5324_CR13) 2010; 411 S Miyazaki (5324_CR14) 2004; 1043 H Saito (5324_CR26) 2006; 5 L Rammer (5324_CR6) 1988; 37 T Kumazawa (5324_CR17) 2007; 44 O Suzuki (5324_CR28) 1989; 29 T Kumazawa (5324_CR19) 2011; 1218 I Broek van den (5324_CR23) 2006; 837 JK Bryner (5324_CR1) 2006; 160 S Desai (5324_CR4) 2006; 19 M Spanakis (5324_CR11) 2009; 23 H Seno (5324_CR8) 1992; 10 A Marumo (5324_CR30) 2005; 88 M Wenk (5324_CR31) 1991; 9 T Kumazawa (5324_CR20) 2010; 28 RH Schwartz (5324_CR5) 2005; 44 H Seno (5324_CR9) 2000; 35 S Ekström (5324_CR24) 2006; 5 B Levine (5324_CR12) 2010; 34 TH Eichhold (5324_CR33) 1997; 698 LH Price (5324_CR3) 2000; 157 H Umezawa (5324_CR27) 2008; 22 AA Monte (5324_CR7) 2010; 70 NA Santagati (5324_CR34) 2005; 28 C Hasegawa (5324_CR16) 2007; 389 M Schulz (5324_CR35) 2003; 58 WC Rodrigues (5324_CR10) 2008; 32 XP Lee (5324_CR18) 2008; 31 5324_CR21 Z Huang (5324_CR29) 2003; 792 C Hasegawa (5324_CR15) 2006; 20 JW Cranston (5324_CR2) 1999; 8 C Wa (5324_CR25) 2006; 349 CT Viswanathan (5324_CR22) 2007; 24 |
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Spectrom2008222333234110.1002/rcm.36131:CAS:528:DC%2BD1cXpsFOnur8%3D – reference: MiyazakiSMorisatoKIshizukaNMinakuchiHShintaniYFurunoMNakanishiKJ Chromatogr A20041043192510.1016/j.chroma.2004.03.0251:CAS:528:DC%2BD2cXlsVSlu7c%3D – reference: EkströmSWallmanLHökDMarko-VargaGLaurellTJ Proteome Res200651071108110.1021/pr050434z – reference: MonteAAChuangRBodmerMBr J Clin Pharmacol20107079479810.1111/j.1365-2125.2010.03747.x1:CAS:528:DC%2BC3MXhsVCgs7g%3D – reference: SpanakisMVizirianakisISMironidou-TzouvelekiMNiopasIBiomed Chromatogr2009231131113710.1002/bmc.12341:CAS:528:DC%2BD1MXht1OrtL3N – reference: LevineBPhippsRJNasoCFahieKFowlerDJ Anal Toxicol2010345065091:CAS:528:DC%2BC3cXht1KitrvL – reference: BrynerJKWangUKHuiJWBedodoMMacDougallCAndersonIBArch Pediatr Adolesc Med20061601217122210.1001/archpedi.160.12.1217 – reference: HuangZZhangSJ Chromatogr B200379224124710.1016/S1570-0232(03)00269-11:CAS:528:DC%2BD3sXlt1akt7w%3D – reference: PriceLHLebelJAm J Psychiatry200015730410.1176/appi.ajp.157.2.3041:STN:280:DC%2BD3c7jslOhtw%3D%3D – reference: DesaiSAldeaDDaneelsESolimanMBraksmajerASKopes-KerrCPJ Am Board Fam Med20061932032310.3122/jabfm.19.3.320 – reference: SenoHKumazawaTIshiiAMatsushimaHWatanabe-SuzukiKSuzukiOJ Mass Spectrom200035333810.1002/(SICI)1096-9888(200001)35:1<33::AID-JMS909>3.0.CO;2-T1:CAS:528:DC%2BD3cXhtVans7c%3D – reference: van den BroekISparidansRWHuitemaADRSchellensJHMBeijnenJHJ Chromatogr B2006837495810.1016/j.jchromb.2006.03.059 – reference: KumazawaTHasegawaCLeeXPHaraKSenoHSuzukiOSatoKJ Pharm Biomed Anal20074460260710.1016/j.jpba.2006.12.0251:CAS:528:DC%2BD2sXmtlans7g%3D – reference: SantagatiNAGottiRRonsisvalleGJ Sep Sci2005281157116210.1002/jssc.2004019421:CAS:528:DC%2BD2MXnvVSqtb4%3D – reference: CranstonJWYoastRArch Fam Med199989910010.1001/archfami.8.2.991:STN:280:DyaK1M3gt1ajtw%3D%3D – reference: MarumoAKumazawaTLeeXPFujimakiKKurikiAHasegawaCSatoKSenoHSuzukiOJ AOAC Int200588165516601:CAS:528:DC%2BD2MXhtlWqsLvO – reference: SchulzMSchmoldtAPharmazie2003584474741:CAS:528:DC%2BD3sXlsVOjs7w%3D – reference: SenoHHattoriHIizumiTKumazawaTSuzukiOJpn J Forensic Toxicol1992102362401:CAS:528:DyaK3sXltFSlu70%3D – reference: LynchKBreaudARVandenbergheHWuAHBClarkeWClin Chim Acta20104111474148110.1016/j.cca.2010.05.0461:CAS:528:DC%2BC3cXptlGjtrk%3D – reference: WaCCernyRHageDSAnal Biochem200634922924110.1016/j.ab.2005.11.0151:CAS:528:DC%2BD28XhtFWhs7c%3D – reference: SuzukiOKumazawaTSenoHHattoriHMed Sci Law1989292422481:STN:280:DyaL1MzmsVWhsg%3D%3D – reference: WenkMTodescoLKellerBFollathFJ Pharm Biomed Anal1991934134410.1016/0731-7085(91)80203-L1:CAS:528:DyaK3MXkvVCks7w%3D – reference: RammerLHolmgrenPSandlerHForensic Sci Int19883723323610.1016/0379-0738(88)90230-71:STN:280:DyaL1czhtlyisA%3D%3D – reference: EichholdTHQuijanoMSeibelWLCruzeCADobsonRLMWehmeyerKRJ Chromatogr B199769814715410.1016/S0378-4347(97)00308-31:CAS:528:DyaK2sXlslems74%3D – reference: U.S. Department of Health and Human Services, Food and Drugs Administration, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM) (2001) Guidance for industry: bioanalytical method validation. http://www.labcompliance.de/documents/FDA/FDA-Others/Laboratory/f-507-bioanalytical-4252fnl.pdf Accessed 1 June – reference: LeeXPHasegawaCKumazawaTShinmenNShojiYSenoHSatoKJ Sep Sci2008312265227110.1002/jssc.2007006271:CAS:528:DC%2BD1cXptVaqsb8%3D – reference: HasegawaCKumazawaTLeeXPMarumoAShinmenNSenoHSatoKAnal Bioanal Chem200738956357010.1007/s00216-007-1460-31:CAS:528:DC%2BD2sXpsFSjtLw%3D – reference: BartolettiRABelpaireFMRosseelMTJ Pharm Biomed Anal1996141281128610.1016/S0731-7085(95)01749-61:CAS:528:DyaK28Xks1Sju70%3D – reference: SchwartzRHClin Pediatr (Phila)20054456556810.1177/000992280504400702 – volume: 19 start-page: 320 year: 2006 ident: 5324_CR4 publication-title: J Am Board Fam Med doi: 10.3122/jabfm.19.3.320 – volume: 389 start-page: 563 year: 2007 ident: 5324_CR16 publication-title: Anal Bioanal Chem doi: 10.1007/s00216-007-1460-3 – volume: 411 start-page: 1474 year: 2010 ident: 5324_CR13 publication-title: Clin Chim Acta doi: 10.1016/j.cca.2010.05.046 – volume: 698 start-page: 147 year: 1997 ident: 5324_CR33 publication-title: J Chromatogr B doi: 10.1016/S0378-4347(97)00308-3 – volume: 1218 start-page: 2521 year: 2011 ident: 5324_CR19 publication-title: J Chromatogr A doi: 10.1016/j.chroma.2011.02.070 – volume: 58 start-page: 447 year: 2003 ident: 5324_CR35 publication-title: Pharmazie – volume: 349 start-page: 229 year: 2006 ident: 5324_CR25 publication-title: Anal Biochem doi: 10.1016/j.ab.2005.11.015 – volume: 10 start-page: 236 year: 1992 ident: 5324_CR8 publication-title: Jpn J Forensic Toxicol – volume: 44 start-page: 602 year: 2007 ident: 5324_CR17 publication-title: J Pharm Biomed Anal doi: 10.1016/j.jpba.2006.12.025 – volume: 1043 start-page: 19 year: 2004 ident: 5324_CR14 publication-title: J Chromatogr A doi: 10.1016/j.chroma.2004.03.025 – volume: 20 start-page: 537 year: 2006 ident: 5324_CR15 publication-title: Rapid Commun Mass Spectrom doi: 10.1002/rcm.2335 – volume: 22 start-page: 2333 year: 2008 ident: 5324_CR27 publication-title: Rapid Commun Mass Spectrom doi: 10.1002/rcm.3613 – volume: 37 start-page: 233 year: 1988 ident: 5324_CR6 publication-title: Forensic Sci Int doi: 10.1016/0379-0738(88)90230-7 – ident: 5324_CR21 – volume: 24 start-page: 1962 year: 2007 ident: 5324_CR22 publication-title: Pharm Res doi: 10.1007/s11095-007-9291-7 – volume: 23 start-page: 1131 year: 2009 ident: 5324_CR11 publication-title: Biomed Chromatogr doi: 10.1002/bmc.1234 – volume: 5 start-page: 1071 year: 2006 ident: 5324_CR24 publication-title: J Proteome Res doi: 10.1021/pr050434z – volume: 9 start-page: 341 year: 1991 ident: 5324_CR31 publication-title: J Pharm Biomed Anal doi: 10.1016/0731-7085(91)80203-L – volume: 160 start-page: 1217 year: 2006 ident: 5324_CR1 publication-title: Arch Pediatr Adolesc Med doi: 10.1001/archpedi.160.12.1217 – volume: 28 start-page: 61 year: 2010 ident: 5324_CR20 publication-title: Forensic Toxicol doi: 10.1007/s11419-010-0097-7 – volume: 31 start-page: 2265 year: 2008 ident: 5324_CR18 publication-title: J Sep Sci doi: 10.1002/jssc.200700627 – volume: 29 start-page: 242 year: 1989 ident: 5324_CR28 publication-title: Med Sci Law doi: 10.1177/002580248902900309 – volume: 8 start-page: 99 year: 1999 ident: 5324_CR2 publication-title: Arch Fam Med doi: 10.1001/archfami.8.2.99 – volume: 32 start-page: 220 year: 2008 ident: 5324_CR10 publication-title: J Anal Toxicol doi: 10.1093/jat/32.3.220 – volume: 70 start-page: 794 year: 2010 ident: 5324_CR7 publication-title: Br J Clin Pharmacol doi: 10.1111/j.1365-2125.2010.03747.x – volume: 44 start-page: 565 year: 2005 ident: 5324_CR5 publication-title: Clin Pediatr (Phila) doi: 10.1177/000992280504400702 – volume: 88 start-page: 1655 year: 2005 ident: 5324_CR30 publication-title: J AOAC Int doi: 10.1093/jaoac/88.6.1655 – volume: 837 start-page: 49 year: 2006 ident: 5324_CR23 publication-title: J Chromatogr B doi: 10.1016/j.jchromb.2006.03.059 – volume: 5 start-page: 1803 year: 2006 ident: 5324_CR26 publication-title: J Proteome Res doi: 10.1021/pr0601178 – volume: 157 start-page: 304 year: 2000 ident: 5324_CR3 publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.157.2.304 – volume: 34 start-page: 506 year: 2010 ident: 5324_CR12 publication-title: J Anal Toxicol doi: 10.1093/jat/34.8.506 – volume: 35 start-page: 33 year: 2000 ident: 5324_CR9 publication-title: J Mass Spectrom doi: 10.1002/(SICI)1096-9888(200001)35:1<33::AID-JMS909>3.0.CO;2-T – volume: 792 start-page: 241 year: 2003 ident: 5324_CR29 publication-title: J Chromatogr B doi: 10.1016/S1570-0232(03)00269-1 – volume: 14 start-page: 1281 year: 1996 ident: 5324_CR32 publication-title: J Pharm Biomed Anal doi: 10.1016/S0731-7085(95)01749-6 – volume: 28 start-page: 1157 year: 2005 ident: 5324_CR34 publication-title: J Sep Sci doi: 10.1002/jssc.200401942 |
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| Snippet | Dextromethorphan was extracted from human plasma samples (100 μL) using MonoTip C
18
tips, which are packed with C
18
-bonded monolithic silica gel that is... Dextromethorphan was extracted from human plasma samples (100 μL) using MonoTip C(18) tips, which are packed with C(18)-bonded monolithic silica gel that is... Dextromethorphan was extracted from human plasma samples (100 μL) using MonoTip [C.sub.18] tips, which are packed with [C.sub.18]-bonded monolithic silica gel... Dextromethorphan was extracted from human plasma samples (100 Delta *mL) using MonoTip C18 tips, which are packed with C18-bonded monolithic silica gel that is... |
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| SubjectTerms | Administration, Oral Analytical Chemistry Biochemistry Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromatographic methods and physical methods associated with chromatography Dextromethorphan Dextromethorphan - administration & dosage Dextromethorphan - blood Dispensing Exact sciences and technology Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - blood Food Science Gas chromatographic methods Gas chromatography Gas Chromatography-Mass Spectrometry Glycine Human Humans Hydroxides Ionization Laboratory Medicine Linearity Male Mass spectrometry Mathematical analysis Methods Methyl alcohol Middle Aged Monitoring/Environmental Analysis Original Paper Reference Standards Regression Sensitivity and Specificity Silica Solid Phase Extraction Spectrometric and optical methods Stimulants |
| Title | Determination of dextromethorphan in human plasma using pipette tip solid-phase extraction and gas chromatography–mass spectrometry |
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