Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation

• Published in: Nature immunology Vol. 21; no. 1; pp. 42 - 53
• Main Authors: Di Gioia, Marco, Spreafico, Roberto, Springstead, James R., Mendelson, Michael M., Joehanes, Roby, Levy, Daniel, Zanoni, Ivan
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.01.2020; Nature Publishing Group
• Subjects: 631/250; 631/250/2504; 631/250/256; 631/250/262; 631/250/516; Alarmins - immunology; Animals; Arteriosclerosis; Atherosclerosis; Biomedical and Life Sciences; Biomedicine; Cells, Cultured; Disease Models, Animal; Female; Gene expression; Glucose metabolism; Glutamine; Glycolysis - physiology; Hypercholesterolemia; Hypercholesterolemia - immunology; Hypercholesterolemia - pathology; Immunology; Infectious Diseases; Inflammation - prevention & control; Interleukins; Lipids; Lipopolysaccharides; Lipopolysaccharides - immunology; Macrophages; Macrophages - immunology; Macrophages - metabolism; Metabolites; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogens; Oxidation-Reduction; Oxidative Phosphorylation; Pathogen-Associated Molecular Pattern Molecules - immunology; Phosphatidylcholines - immunology; Phospholipids; Physiological aspects; Plaque, Atherosclerotic - pathology; Plaque, Atherosclerotic - prevention & control; Scientific equipment and supplies industry; United States

Pathogen-associated molecular patterns (PAMPs) have the capacity to couple inflammatory gene expression to changes in macrophage metabolism, both of which influence subsequent inflammatory activities. Similar to their microbial counterparts, several self-encoded damage-associated molecular patterns...