Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice

• Published in: Molecular psychiatry Vol. 25; no. 5; pp. 993 - 1005
• Main Authors: Mayo, Leah M., Asratian, Anna, Lindé, Johan, Holm, Lovisa, Nätt, Daniel, Augier, Gaëlle, Stensson, Niclas, Vecchiarelli, Haley A., Balsevich, Georgia, Aukema, Robert J., Ghafouri, Bijar, Spagnolo, Primavera A., Lee, Francis S., Hill, Matthew N., Heilig, Markus
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2020; Nature Publishing Group
• Subjects: 631/208; 631/378; 64/110; 692/699/476; 82/58; Adolescent; Adult; Alleles; Amidohydrolases - antagonists & inhibitors; Amidohydrolases - genetics; Amidohydrolases - metabolism; Amygdala; Analysis; Anandamide; Animals; Arachidonic Acids - metabolism; Behavior; Behavioral health care; Behavioral Sciences; Biological Psychology; Endocannabinoids - metabolism; Enzymes; Evidence-based medicine; Extinction behavior; Extinction, Psychological - drug effects; Fatty acids; Fatty-acid amide hydrolase; Fear - drug effects; Fear conditioning; Female; Genotypes; Homozygotes; Humans; Hydrolase; Male; Medicine; Medicine & Public Health; Mental disorders; Mice; Neurosciences; Pharmacotherapy; Polyunsaturated Alkamides - metabolism; Post traumatic stress disorder; Prefrontal cortex; Protective Agents - metabolism; Psychiatry; Stress Disorders, Post-Traumatic - drug therapy; Stress Disorders, Post-Traumatic - genetics; Stress Disorders, Post-Traumatic - metabolism; Stress Disorders, Post-Traumatic - psychology; Young Adult

Post-traumatic stress disorder (PTSD) is a common, debilitating condition with limited treatment options. Extinction of fear memories through prolonged exposure therapy, the primary evidence-based behavioral treatment for PTSD, has only partial efficacy. In mice, pharmacological inhibition of fatty...